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Index > Protein center > Cnga4(Gene name) > Mouse
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  • Cnga4 (Gene name),
  • Cyclic nucleotide-gated cation channel alpha-4 (Protein name ),  CNGA4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Cnga4;
    Protein name:
    Cyclic nucleotide-gated cation channel alpha-4;
    Alternative:
    Cyclic nucleotide-gated channel alpha-4(CNG channel alpha-4;CNG-4;CNG4);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory neurons.
    Function:
    Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    575
    Sequence:
    50:
    MSQDSKVKTT | ESTPPAPTKA | RKWLPVLDPS | GDYYYWWLNT | MVFPIMYNLI | 
    100:
    IVVCRACFPD | LQHSYLVAWF | VLDYTSDLLY | LLDIGVRFHT | GFLEQGILVV | 
    150:
    DKSMIASRYV | RTWSFLLDLA | SLVPTDAAYV | QLGPHIPTLR | LNRFLRVPRL | 
    200:
    FEAFDRTETR | TAYPNAFRIA | KLMIYIFVVI | HWNSCLYFAL | SRYLGFGRDA | 
    250:
    WVYPDPAQPG | FERLRRQYLY | SFYFSTLILT | TVGDTPLPAR | EEEYLFMVGD | 
    300:
    FLLAVMGFAT | IMGSMSSVIY | NMNTADAAFY | PDHALVKKYM | KLQHVNRRLE | 
    350:
    RRVIDWYQHL | QINKKMTNEV | AILQHLPERL | RAEVAVSVHL | STLSRVQIFQ | 
    400:
    NCEASLLEEL | VLKLQPQTYS | PGEYVCRKGD | IGREMYIIRE | GQLAVVADDG | 
    450:
    VTQYAVLGAG | LYFGEISIIN | IKGNMSGNRR | TANIKSLGYS | DLFCLSKEDL | 
    500:
    REVLSEYPQA | QAVMEEKGRE | ILLKMNKLDV | NAEAAEIALQ | EATESRLKGL | 
    550:
    DQQLDDLQTK | FARLLAELES | SALKIAYRIE | RLEWQTREWP | MPDDMGEADD | 
    575:
    EAEPGEGTSK | DGEEKAGQEG | PSGLE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-4
    ELISA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-4
    ELISA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-4
    CLIA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-4
    CLIA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-4
    CLIA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-4
    Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-4
    Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-4
    Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-4
    Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-4
    Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-4
    Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-4
    Protein for Mouse Cyclic nucleotide-gated cation channel alpha-4
    Protein for Mouse Cyclic nucleotide-gated cation channel alpha-4
    Protein for Mouse Cyclic nucleotide-gated cation channel alpha-4

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Epididymis.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
    3. 3.
      "Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation."
      Munger S.D. , Lane A.P. , Zhong H. , Leinders-Zufall T. , Yau K.-W. , Zufall F. , Reed R.R.
      Science294:2172-2175(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    4. 4.
      "Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice."
      Kelliher K.R. , Ziesmann J. , Munger S.D. , Reed R.R. , Zufall F.
      Proc. Natl. Acad. Sci. U.S.A.100:4299-4304(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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