CNGB3 ELISA Kit for Dog(Canis familiaris) | EIAab.comCNGB3 ELISA Kit for Dog(Canis familiaris)

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CNGB3 (Gene name),

Cyclic nucleotide-gated cation channel beta-3 (Protein name ), CNGB3_CANFA from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CNGB3;

Protein name:

Cyclic nucleotide-gated cation channel beta-3;

Alternative:

Cyclic nucleotide-gated cation channel modulatory subunit;Cone photoreceptor cGMP-gated channel subunit beta;Cyclic nucleotide-gated channel beta-3(CNG channel beta-3);

Organism:

Dog (Canis familiarisCanis lupus familiaris).

General Annotation

Sub Unit:

Heterooligomeric complex with CNGA3.

Function:

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

782

Sequence:

50:

100:

150:

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400:

450:

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550:

600:

650:

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750:

782:

GTTRQSLIIS | MAPSAEAGEE | VLTIEVKEKA | KQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8MJD7

Pfam:

PF00027

UniGene:

Cfa.72

KEGG:

cfa:403554

Uniprot:

Q8MJD7

FOR

ELISA Kit for Dog Cyclic nucleotide-gated cation channel beta-3

CLIA Kit for Dog Cyclic nucleotide-gated cation channel beta-3

Polyclonal Antibody for Dog Cyclic nucleotide-gated cation channel beta-3

Monoclonal Antibody for Dog Cyclic nucleotide-gated cation channel beta-3

Protein for Dog Cyclic nucleotide-gated cation channel beta-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3."
Sidjanin D.J. , Lowe J.K. , McElwee J.L. , Milne B.S. , Phippen T.M. , Sargan D.R. , Aguirre G.D. , Acland G.M. , Ostrander E.A.
Hum. Mol. Genet.11:1823-1833(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT CD ASN-262
2.

"Genetic heterogeneity of day blindness in Alaskan Malamutes."
Seddon J.M. , Hampson E.C.G.M. , Smith R.I.E. , Hughes I.P.
Anim. Genet.37:407-410(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: Alaskan malamute.

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