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Index > Protein center > C3(Gene name) > Human
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  • C3 (Gene name),
  • Complement C3 (Protein name ),  CO3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    C3(CPAMD1);
    Protein name:
    Complement C3;
    Alternative:
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with VSIG4. C3b interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 2 (HHV-2) envelope glycoprotein C; this interaction inhibits the activation of the complement system. Interacts with S.aureus immunoglobulin-binding protein sbi, this prevents interaction between C3dg and CR2. Interacts with S.aureus fib.
    Function:
    Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    1663
    Sequence:
    50:
    MGPTSGPSLL | LLLLTHLPLA | LGSPMYSIIT | PNILRLESEE | TMVLEAHDAQ | 
    100:
    GDVPVTVTVH | DFPGKKLVLS | SEKTVLTPAT | NHMGNVTFTI | PANREFKSEK | 
    150:
    GRNKFVTVQA | TFGTQVVEKV | VLVSLQSGYL | FIQTDKTIYT | PGSTVLYRIF | 
    200:
    TVNHKLLPVG | RTVMVNIENP | EGIPVKQDSL | SSQNQLGVLP | LSWDIPELVN | 
    250:
    MGQWKIRAYY | ENSPQQVFST | EFEVKEYVLP | SFEVIVEPTE | KFYYIYNEKG | 
    300:
    LEVTITARFL | YGKKVEGTAF | VIFGIQDGEQ | RISLPESLKR | IPIEDGSGEV | 
    350:
    VLSRKVLLDG | VQNPRAEDLV | GKSLYVSATV | ILHSGSDMVQ | AERSGIPIVT | 
    400:
    SPYQIHFTKT | PKYFKPGMPF | DLMVFVTNPD | GSPAYRVPVA | VQGEDTVQSL | 
    450:
    TQGDGVAKLS | INTHPSQKPL | SITVRTKKQE | LSEAEQATRT | MQALPYSTVG | 
    500:
    NSNNYLHLSV | LRTELRPGET | LNVNFLLRMD | RAHEAKIRYY | TYLIMNKGRL | 
    550:
    LKAGRQVREP | GQDLVVLPLS | ITTDFIPSFR | LVAYYTLIGA | SGQREVVADS | 
    600:
    VWVDVKDSCV | GSLVVKSGQS | EDRQPVPGQQ | MTLKIEGDHG | ARVVLVAVDK | 
    650:
    GVFVLNKKNK | LTQSKIWDVV | EKADIGCTPG | SGKDYAGVFS | DAGLTFTSSS | 
    700:
    GQQTAQRAEL | QCPQPAARRR | RSVQLTEKRM | DKVGKYPKEL | RKCCEDGMRE | 
    750:
    NPMRFSCQRR | TRFISLGEAC | KKVFLDCCNY | ITELRRQHAR | ASHLGLARSN | 
    800:
    LDEDIIAEEN | IVSRSEFPES | WLWNVEDLKE | PPKNGISTKL | MNIFLKDSIT | 
    850:
    TWEILAVSMS | DKKGICVADP | FEVTVMQDFF | IDLRLPYSVV | RNEQVEIRAV | 
    900:
    LYNYRQNQEL | KVRVELLHNP | AFCSLATTKR | RHQQTVTIPP | KSSLSVPYVI | 
    950:
    VPLKTGLQEV | EVKAAVYHHF | ISDGVRKSLK | VVPEGIRMNK | TVAVRTLDPE | 
    1000:
    RLGREGVQKE | DIPPADLSDQ | VPDTESETRI | LLQGTPVAQM | TEDAVDAERL | 
    1050:
    KHLIVTPSGC | GEQNMIGMTP | TVIAVHYLDE | TEQWEKFGLE | KRQGALELIK | 
    1100:
    KGYTQQLAFR | QPSSAFAAFV | KRAPSTWLTA | YVVKVFSLAV | NLIAIDSQVL | 
    1150:
    CGAVKWLILE | KQKPDGVFQE | DAPVIHQEMI | GGLRNNNEKD | MALTAFVLIS | 
    1200:
    LQEAKDICEE | QVNSLPGSIT | KAGDFLEANY | MNLQRSYTVA | IAGYALAQMG | 
    1250:
    RLKGPLLNKF | LTTAKDKNRW | EDPGKQLYNV | EATSYALLAL | LQLKDFDFVP | 
    1300:
    PVVRWLNEQR | YYGGGYGSTQ | ATFMVFQALA | QYQKDAPDHQ | ELNLDVSLQL | 
    1350:
    PSRSSKITHR | IHWESASLLR | SEETKENEGF | TVTAEGKGQG | TLSVVTMYHA | 
    1400:
    KAKDQLTCNK | FDLKVTIKPA | PETEKRPQDA | KNTMILEICT | RYRGDQDATM | 
    1450:
    SILDISMMTG | FAPDTDDLKQ | LANGVDRYIS | KYELDKAFSD | RNTLIIYLDK | 
    1500:
    VSHSEDDCLA | FKVHQYFNVE | LIQPGAVKVY | AYYNLEESCT | RFYHPEKEDG | 
    1550:
    KLNKLCRDEL | CRCAEENCFI | QKSDDKVTLE | ERLDKACEPG | VDYVYKTRLV | 
    1600:
    KVQLSNDFDE | YIMAIEQTIK | SGSDEVQVGQ | QRTFISPIKC | REALKLEEKK | 
    1650:
    HYLMWGLSSD | FWGEKPNLSY | IIGKDTWVEH | WPEEDECQDE | ENQKQCQDLG | 
    1663:
    AFTESMVVFG | CPN
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    UniGene:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Complement C3
    Cat.:
    E0861h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Complement C3
    Cat.:
    E0861m
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    Packing:
    96T
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    ELISA Kit for Human Complement C3
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    ELISA Kit for Human Complement C3
    Cat.:
    E0861r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Complement C3
    Cat.:
    E0861b
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Human Complement C3
    MSDS:
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    CLIA Kit for Human Complement C3
    Cat.:
    U0861b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement C3
    MSDS:
    Please sign in first.
    CLIA Kit for Human Complement C3
    Cat.:
    U0861r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement C3
    MSDS:
    Please sign in first.
    CLIA Kit for Human Complement C3
    Cat.:
    U0861m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Complement C3
    Cat.:
    U0861h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Complement C3
    Polyclonal Antibody for Human Complement C3
    Polyclonal Antibody for Human Complement C3
    Cat.:
    P0861Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement C3
    Cat.:
    P0861Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement C3
    Polyclonal Antibody for Human Complement C3
    Cat.:
    P0861Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Complement C3
    Monoclonal Antibody for Human Complement C3
    Monoclonal Antibody for Human Complement C3
    Monoclonal Antibody for Human Complement C3
    Monoclonal Antibody for Human Complement C3
    Monoclonal Antibody for Human Complement C3
    Protein for Human Complement C3
    Protein for Human Complement C3
    Cat.:
    R0861h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Complement C3
    Protein for Human Complement C3
    Protein for Human Complement C3
    Protein for Human Complement C3

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    Linearity
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    References
    1. 1.
      "Human complement component C3: cDNA coding sequence and derived primary structure."
      de Bruijn M.H.L. , Fey G.H.
      Proc. Natl. Acad. Sci. U.S.A.82:708-712(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LEU-314
    2. 2.
      SeattleSNPs variation discovery resource
      Submitted (2003-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-102; LEU-314; LYS-863; ASP-1224 AND THR-1367
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis."
      Baldo A. , Sniderman A.D. , St-Luce S. , Avramoglu R.K. , Maslowska M. , Hoang B. , Monge J.C. , Bell A. , Mulay S. , Cianflone K.
      J. Clin. Invest.92:1543-1547(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS;IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION
    6. 6.
      "Human anaphylatoxin (C3a) from the third component of complement. Primary structure."
      Hugli T.E.
      J. Biol. Chem.250:8293-8301(1975) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 672-748
    7. 7.
      "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma."
      Oxvig C. , Haaning J. , Kristensen L. , Wagner J.M. , Rubin I. , Stigbrand T. , Gleich G.J. , Sottrup-Jensen L.
      J. Biol. Chem.270:13645-13651(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 955-966;SUBUNIT
      tissue: Serum.
    8. 8.
      "Third component of human complement: localization of the internal thiolester bond."
      Thomas M.L. , Janatova J. , Gray W.R. , Tack B.F.
      Proc. Natl. Acad. Sci. U.S.A.79:1054-1058(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 988-1036
    9. 9.
      "A 34-amino acid peptide of the third component of complement mediates properdin binding."
      Daoudaki M.E. , Becherer J.D. , Lambris J.D.
      J. Immunol.140:1577-1580(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1409-1563
    10. 10.
      "Complement component C3b binds directly to purified glycoprotein C of herpes simplex virus types 1 and 2."
      Eisenberg R.J. , Ponce de Leon M. , Friedman H.M. , Fries L.F. , Frank M.M. , Hastings J.C. , Cohen G.H.
      Microb. Pathog.3:423-435(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HERPES SIMPLEX VIRUS HHV-1 AND HHV-2 GYCOPROTEIN C
    11. 11.
      "Purification and characterization of acylation stimulating protein."
      Cianflone K.M. , Sniderman A.D. , Walsh M.J. , Vu H.T. , Gagnon J. , Rodriguez M.A.
      J. Biol. Chem.264:426-430(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3."
      Isaac L. , Isenman D.E.
      J. Biol. Chem.267:10062-10069(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF THE THIOESTER BOND REGION
    13. 13.
      "Disulfide bridges in human complement component C3b."
      Dolmer K. , Sottrup-Jensen L.
      FEBS Lett.315:85-90(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    14. 14.
      "Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line."
      Tao Y. , Cianflone K. , Sniderman A.D. , Colby-Germinario S.P. , Germinario R.J.
      Biochim. Biophys. Acta1344:221-229(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      "Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period."
      Saleh J. , Summers L.K. , Cianflone K. , Fielding B.A. , Sniderman A.D. , Frayn K.N.
      J. Lipid Res.39:884-891(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;TISSUE SPECIFICITY;FUNCTION
    16. 16.
      "Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity."
      Murray I. , Kohl J. , Cianflone K.
      Biochem. J.342:41-48(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des Arg(74)."
      Cain S.A. , Monk P.N.
      J. Biol. Chem.277:7165-7169(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C5AR2
    18. 18.
      "The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein."
      Kalant D. , Cain S.A. , Maslowska M. , Sniderman A.D. , Cianflone K. , Monk P.N.
      J. Biol. Chem.278:11123-11129(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C5AR2
    19. 19.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-85
    20. 20.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-939
      tissue: Plasma.
    21. 21.
      "Acylation-stimulating protein: effect of acute exercise and endurance training."
      Schrauwen P. , Hesselink M.K. , Jain M. , Cianflone K.
      Int. J. Obes. Relat. Metab. Disord.29:632-638(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EFFECTS OF EXERCISE
    22. 22.
      "C5L2 is a functional receptor for acylation-stimulating protein."
      Kalant D. , MacLaren R. , Cui W. , Samanta R. , Monk P.N. , Laporte S.A. , Cianflone K.
      J. Biol. Chem.280:23936-23944(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    23. 23.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-85; ASN-939 AND ASN-1617
      tissue: Plasma.
    24. 24.
      "Relationships among acylation stimulating protein, adiponectin and complement C3 in lean vs obese type 2 diabetes."
      Yang Y. , Lu H.L. , Zhang J. , Yu H.Y. , Wang H.W. , Zhang M.X. , Cianflone K.
      Int. J. Obes. Relat. Metab. Disord.30:439-446(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH TYPE 2 DIABETES
    25. 25.
      "Targeting the signaling pathway of acylation stimulating protein."
      Maslowska M. , Legakis H. , Assadi F. , Cianflone K.
      J. Lipid Res.47:643-652(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION
    26. 26.
      "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
      Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-85
      tissue: Platelet.
    27. 27.
      "Acylation stimulating protein but not complement C3 associates with metabolic syndrome components in Chinese children and adolescents."
      Wamba P.C. , Mi J. , Zhao X.Y. , Zhang M.X. , Wen Y. , Cheng H. , Hou D.Q. , Cianflone K.
      Eur. J. Endocrinol.159:781-790(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH OBESITY
    28. 28.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-85
      tissue: Liver.
    29. 29.
      "C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation."
      Cui W. , Simaan M. , Laporte S. , Lodge R. , Cianflone K.
      Mol. Immunol.46:3086-3098(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    30. 30.
      "Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure."
      Isenman D.E. , Leung E. , Mackay J.D. , Bagby S. , van den Elsen J.M.
      J. Immunol.184:1946-1955(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-1029; GLU-1030; GLU-1032; GLU-1035; ARG-1042; ASP-1140; GLU-1153; ASP-1156; GLU-1159; GLU-1160; ASN-1163 AND LYS-1284;INTERACTION WITH CR2 AND S.AUREUS SBI
    31. 31.
      "Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking."
      Shaw C.D. , Storek M.J. , Young K.A. , Kovacs J.M. , Thurman J.M. , Holers V.M. , Hannan J.P.
      J. Mol. Biol.404:697-710(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-1029; GLU-1030; GLU-1032; GLU-1110; ASP-1115; ASP-1121; ASP-1140; GLU-1153; ASP-1156; GLU-1159; GLU-1160 AND ASN-1163;INTERACTION WITH CR2
    32. 32.
      "Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population."
      Onat A. , Hergenc G. , Can G. , Kaya Z. , Yuksel H.
      Metabolism59:628-634(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH CORONARY HEART DISEASE
    33. 33.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    34. 34.
      "Secondary structure of complement component C3a anaphylatoxin in solution as determined by NMR spectroscopy: differences between crystal and solution conformations."
      Nettesheim D.G. , Edalji R.P. , Mollison K.W. , Greer J. , Zuiderweg E.R.P.
      Proc. Natl. Acad. Sci. U.S.A.85:5036-5040(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF C3A
    35. 35.
      "X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2."
      Nagar B. , Jones R.G. , Diefenbach R.J. , Isenman D.E. , Rini J.M.
      Science280:1277-1281(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF C3D
    36. 36.
      "Structure of complement receptor 2 in complex with its C3d ligand."
      Szakonyi G. , Guthridge J.M. , Li D. , Young K. , Holers V.M. , Chen X.S.
      Science292:1725-1728(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF C3D IN COMPLEX WITH CR2;MUTAGENESIS OF 1108-ILE-LEU-1109 AND ASN-1163
    37. 37.
      "Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study."
      Gilbert H.E. , Eaton J.T. , Hannan J.P. , Holers V.M. , Perkins S.J.
      J. Mol. Biol.346:859-873(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY SCATTERING SOLUTION STRUCTURE OF C3D IN COMPLEX WITH CR2
    38. 38.
      "Structures of complement component C3 provide insights into the function and evolution of immunity."
      Janssen B.J.C. , Huizinga E.G. , Raaijmakers H.C.A. , Roos A. , Daha M.R. , Nilsson-Ekdahl K. , Nilsson B. , Gros P.
      Nature437:505-511(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF C3C;X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF C3
    39. 39.
      "Structure of C3b reveals conformational changes that underlie complement activity."
      Janssen B.J.C. , Christodoulidou A. , McCarthy A. , Lambris J.D. , Gros P.
      Nature444:213-216(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF C3B
    40. 40.
      "Structure of C3b in complex with CRIg gives insights into regulation of complement activation."
      Wiesmann C. , Katschke K.J. , Yin J. , Helmy K.Y. , Steffek M. , Fairbrother W.J. , McCallum S.A. , Embuscado L. , DeForge L. , Hass P.E. , van Lookeren Campagne M.
      Nature444:217-220(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF C3C IN COMPLEX WITH VSIG4;X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF C3B IN COMPLEX WITH VSIG4;GLYCOSYLATION AT ASN-85 AND ASN-939
    41. 41.
      "Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition."
      Janssen B.J. , Halff E.F. , Lambris J.D. , Gros P.
      J. Biol. Chem.282:29241-29247(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 23-936 AND 1321-1663 IN COMPLEX WITH INHIBITOR COMPSTATIN;DISULFIDE BONDS;GLYCOSYLATION AT ASN-85
    42. 42.
      "A structural basis for complement inhibition by Staphylococcus aureus."
      Hammel M. , Sfyroera G. , Ricklin D. , Magotti P. , Lambris J.D. , Geisbrecht B.V.
      Nat. Immunol.8:430-437(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 996-1287 IN COMPLEX WITH S.AUREUS FIB
    43. 43.
      "A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d."
      Clark E.A. , Crennell S. , Upadhyay A. , Zozulya A.V. , Mackay J.D. , Svergun D.I. , Bagby S. , van den Elsen J.M.
      Mol. Immunol.48:452-462(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 996-1303 IN COMPLEX WITH S.AUREUS SBI;SUBUNIT
    44. 44.
      "A crystal structure of the complex between human complement receptor 2 and its ligand C3d."
      van den Elsen J.M. , Isenman D.E.
      Science332:608-611(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.16 ANGSTROMS) OF 996-1303 IN COMPLEX WITH CR2;INTERACTION WITH CR2
    45. 45.
      "The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3."
      Poznansky M.C. , Clissold P.M. , Lachmann P.J.
      J. Immunol.143:1254-1258(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C3S ASN-1216
    46. 46.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;RETRACTION
    47. 47.
      "Molecular basis of polymorphisms of human complement component C3."
      Botto M. , Yong Fong K. , So A.K. , Koch C. , Walport M.J.
      J. Exp. Med.172:1011-1017(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLY-102 AND LEU-314
    48. 48.
      "Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (Asp549 to Asn) impairs C3 secretion."
      Singer L. , Whitehead W.T. , Akama H. , Katz Y. , Fishelson Z. , Wetsel R.A.
      J. Biol. Chem.269:28494-28499(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C3D ASN-549
    49. 49.
      "A novel C3 allotype C3'F02'has an amino acid substitution that may inhibit iC3b synthesis and cause C3-hypocomplementemia."
      Watanabe Y. , Matsui N. , Yan K. , Nishimukai H. , Tokunaga K. , Juji T. , Kobayashi N. , Kohsaka T.
      Mol. Immunol.30:62-62(1993)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C3D GLN-1320
    50. 50.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT GLY-102 WITH ARMD9
    51. 51.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS5 GLN-592; TRP-592; TRP-735; VAL-1094; ASN-1115; TRP-1158; LYS-1161 AND ASP-1464;CHARACTERIZATION OF VARIANTS AHUS5 GLN-592; TRP-592; VAL-1094; ASN-1115 AND LYS-1161
    52. 52.
      "Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
      Maga T.K. , Nishimura C.J. , Weaver A.E. , Frees K.L. , Smith R.J.H.
      Hum. Mutat.31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS5 VAL-603 AND LEU-1042
    53. 53.
      "Quantitative detection of single amino acid polymorphisms by targeted proteomics."
      Su Z.D. , Sun L. , Yu D.X. , Li R.X. , Li H.X. , Yu Z.J. , Sheng Q.H. , Lin X. , Zeng R. , Wu J.R.
      J. Mol. Cell Biol.3:309-315(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-549;IDENTIFICATION BY MASS SPECTROMETRY
    54. 54.
      "Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk."
      Heurich M. , Martinez-Barricarte R. , Francis N.J. , Roberts D.L. , Rodriguez de Cordoba S. , Morgan B.P. , Harris C.L.
      Proc. Natl. Acad. Sci. U.S.A.108:8761-8766(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT GLY-102
    55. 55.
      "Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration."
      Seddon J.M. , Yu Y. , Miller E.C. , Reynolds R. , Tan P.L. , Gowrisankar S. , Goldstein J.I. , Triebwasser M. , Anderson H.E. , Zerbib J. , Kavanagh D. , Souied E. , Katsanis N. , Daly M.J. , Atkinson J.P. , Raychaudhuri S.
      Nat. Genet.45:1366-1370(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARMD9 GLN-155;CHARACTERIZATION OF VARIANT ARMD9 GLN-155
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