C4b ELISA Kit for Mouse(Mus musculus) | EIAab.comC4b ELISA Kit for Mouse(Mus musculus) | EIAab.com

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C4b (Gene name),

Complement C4-B (Protein name ), CO4B_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

C4b(C4);

Protein name:

Complement C4-B;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain.

Function:

C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

1738

Sequence:

50:

MRLLWGLAWV | FSFCASSLQK | PRLLLFSPSV | VNLGTPLSVG | VQLLDAPPGQ |

100:

EVKGSVFLRN | PKGGSCSPKK | DFKLSSGDDF | VLLSLEVPLE | DVRSCGLFDL |

150:

RRAPHIQLVA | QSPWLRNTAF | KATETQGVNL | LFSSRRGHIF | VQTDQPIYNP |

200:

GQRVRYRVFA | LDQKMRPSTD | FLTITVENSH | GLRVLKKEIF | TSTSIFQDAF |

250:

TIPDISEPGT | WKISARFSDG | LESNRSTHFE | VKKYVLPNFE | VKITPWKPYI |

300:

LMVPSNSDEI | QLDIQARYIY | GKPVQGVAYT | RFALMDEQGK | RTFLRGLETQ |

350:

AKLVEGRTHI | SISKDQFQAA | LDKINIGVRD | LEGLRLYAAT | AVIESPGGEM |

400:

EEAELTSWRF | VSSAFSLDLS | RTKRHLVPGA | HFLLQALVQE | MSGSEASNVP |

450:

VKVSATLVSG | SDSQVLDIQQ | STNGIGQVSI | SFPIPPTVTE | LRLLVSAGSL |

500:

YPAIARLTVQ | APPSRGTGFL | SIEPLDPRSP | SVGDTFILNL | QPVGIPAPTF |

550:

SHYYYMIISR | GQIMAMGREP | RKTVTSVSVL | VDHQLAPSFY | FVAYFYHQGH |

600:

PVANSLLINI | QSRDCEGKLQ | LKVDGAKEYR | NADMMKLRIQ | TDSKALVALG |

650:

AVDMALYAVG | GRSHKPLDMS | KVFEVINSYN | VGCGPGGGDD | ALQVFQDAGL |

700:

AFSDGDRLTQ | TREDLSCPKE | KKSRQKRNVN | FQKAVSEKLG | QYSSPDAKRC |

750:

CQDGMTKLPM | KRTCEQRAAR | VPQQACREPF | LSCCKFAEDL | RRNQTRSQAH |

800:

LARNNHNMLQ | EEDLIDEDDI | LVRTSFPENW | LWRVEPVDSS | KLLTVWLPDS |

850:

MTTWEIHGVS | LSKSKGLCVA | KPTRVRVFRK | FHLHLRLPIS | IRRFEQFELR |

900:

PVLYNYLNDD | VAVSVHVTPV | EGLCLAGGGM | MAQQVTVPAG | SARPVAFSVV |

950:

PTAAANVPLK | VVARGVFDLG | DAVSKILQIE | KEGAIHREEL | VYNLDPLNNL |

1000:

GRTLEIPGSS | DPNIVPDGDF | SSLVRVTASE | PLETMGSEGA | LSPGGVASLL |

1050:

RLPQGCAEQT | MIYLAPTLTA | SNYLDRTEQW | SKLSPETKDH | AVDLIQKGYM |

1100:

RIQQFRKNDG | SFGAWLHRDS | STWLTAFVLK | ILSLAQEQVG | NSPEKLQETA |

1150:

SWLLAQQLGD | GSFHDPCPVI | HRAMQGGLVG | SDETVALTAF | VVIALHHGLD |

1200:

VFQDDDAKQL | KNRVEASITK | ANSFLGQKAS | AGLLGAHAAA | ITAYALTLTK |

1250:

ASEDLRNVAH | NSLMAMAEET | GEHLYWGLVL | GSQDKVVLRP | TAPRSPTEPV |

1300:

PQAPALWIET | TAYALLHLLL | REGKGKMADK | AASWLTHQGS | FHGAFRSTQD |

1350:

TVVTLDALSA | YWIASHTTEE | KALNVTLSSM | GRNGLKTHGL | HLNNHQVKGL |

1400:

EEELKFSLGS | TISVKVEGNS | KGTLKILRTY | NVLDMKNTTC | QDLQIEVKVT |

1450:

GAVEYAWDAN | EDYEDYYDMP | AADDPSVPLQ | PVTPLQLFEG | RRSRRRREAP |

1500:

KVVEEQESRV | QYTVCIWRNG | KLGLSGMAIA | DITLLSGFHA | LRADLEKLTS |

1550:

LSDRYVSHFE | TDGPHVLLYF | DSVPTTRECV | GFGASQEVVV | GLVQPSSAVL |

1600:

YDYYSPDHKC | SVFYAAPTKS | QLLATLCSGD | VCQCAEGKCP | RLLRSLERRV |

1650:

EDKDGYRMRF | ACYYPRVEYG | FTVKVLREDG | RAAFRLFESK | ITQVLHFRKD |

1700:

TMASIGQTRN | FLSRASCRLR | LEPNKEYLIM | GMDGETSDNK | GDPQYLLDSN |

1738:

TWIEEMPSEQ | MCKSTRHRAA | CFQLKDFLME | FSSRGCQV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

KEGG:

String:

UniGene:

SMR:

Uniprot:

FOR

ELISA Kit for Mouse Complement C4-B

Cat.:

E11254m

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Mouse Complement C4-B

Cat.:

E11254h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Mouse Complement C4-B

Cat.:

U11254m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Complement C4-B

Cat.:

U11254h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Complement C4-B

Cat.:

P11254Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Complement C4-B

Monoclonal Antibody for Mouse Complement C4-B

Monoclonal Antibody for Mouse Complement C4-B

Protein for Mouse Complement C4-B

Protein for Mouse Complement C4-B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤4.8%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤8.9%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Recovery was determined by spiking various levels of CO4B into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	101	94-104
Plasma	99	93-106

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of CO4B and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-110%	94-107%	95-105%	93-109%
EDTA plasma(n=5)	94-105%	96-102%	92-104%	90-108%
heparin plasma(n=5)	93-107%	91-106%	93-106%	94-103%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects."
Nonaka M. , Nakayama K. , Yeul Y.D. , Takahashi M.
J. Biol. Chem.260:10936-10943(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: FM.
2.

"Complete cDNA sequence of the fourth component of murine complement."
Sepich D.S. , Noonan D.J. , Ogata R.T.
Proc. Natl. Acad. Sci. U.S.A.82:5895-5899(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: B10.WR.
3.

"Sequence of the gene for murine complement component C4."
Ogata R.T. , Rosa P.A. , Zepf N.E.
J. Biol. Chem.264:16565-16572(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: B10.WR.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Inner ear.
5.

"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T. , Rowen L. , Aguado B. , Ahearn M.E. , Madan A. , Qin S. , Campbell R.D. , Hood L.
Genome Res.13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: 129.
6.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: CD-1.
tissue: Germ cell.
tissue: Neural stem cell.
8.

"Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp."
Nonaka M. , Nakayama K. , Yeul Y.D. , Shimizu A. , Takahashi M.
Immunol. Rev.87:81-99(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-128
strain: FM.
9.

"Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes."
Nonaka M. , Kimura H. , Yeul Y.D. , Yokoyama S. , Nakayama K. , Takahashi M.
Proc. Natl. Acad. Sci. U.S.A.83:7883-7887(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21
10.

"Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp)."
Hemenway C. , Kalff M. , Stavenhagen J. , Walthall D. , Robins D.
Nucleic Acids Res.14:2539-2554(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 591-1738
strain: C57BL/10 X DBA/2.
11.

"Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein."
Nonaka M. , Takahashi M. , Natsuume-Sakai S. , Nonaka M. , Tanaka S. , Shimizu A. , Honjo T.
Proc. Natl. Acad. Sci. U.S.A.81:6822-6826(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 651-810 AND 924-1083
12.

"Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4."
Taillon-Miller P.A. , Shreffler D.C.
J. Immunol.141:2382-2387(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 961-1290
13.

"C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4."
Ogata R.T. , Zepf N.E.
Eur. J. Immunol.20:1607-1610(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1099-1142
strain: B10.BR.
strain: B10.WR.
strain: C3H/He.
strain: C57BL/6.
strain: CBA/J.
strain: DBA/2.
14.

"Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp."
Levi-Strauss M. , Tosi M. , Steinmetz M. , Klein J. , Meo T.
Proc. Natl. Acad. Sci. U.S.A.82:1746-1750(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1105-1449
15.

"Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component."
Tosi M. , Levi-Strauss M. , Duponchel C. , Meo T.
Philos. Trans. R. Soc. Lond., B, Biol. Sci.306:389-394(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1257-1376
16.

"cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4)."
Ogata R.T. , Shreffler D.C. , Sepich D.S. , Lilly S.P.
Proc. Natl. Acad. Sci. U.S.A.80:5061-5065(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1360-1511
17.

"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
Bernhard O.K. , Kapp E.A. , Simpson R.J.
J. Proteome Res.6:987-995(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1324
strain: C57BL/6.
tissue: Plasma.

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