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Index > Protein center > C4(Gene name) > Rat
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  • C4 (Gene name),
  • Complement C4 (Protein name ),  CO4_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    C4(C4a);
    Protein name:
    Complement C4;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    This protein is synthesized as a single-chain precursor and, prior to secretion, is enzymatically cleaved to form a trimer of non-identical chains (alpha, beta and gamma).
    Function:
    Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    1737
    Sequence:
    50:
    MRLLWGLAWA | FSFFASSLQK | PRLLLFSPSV | VNLGTPLSVG | VQLLDAPAGQ | 
    100:
    EVKGSVYLRN | PTSGPCSPKK | DFKLSSGNDF | VLLRLEVPLK | DVRSCGLFGL | 
    150:
    RRAPHIQLVA | HSPWLKNTAS | KATETQGVNL | LFSSRRGHIF | VQTDQPIYNP | 
    200:
    GQRVRYRVFA | LDQKMRPSTD | TLTVTVENSH | GLRVRKKEVF | APTSIFQDDF | 
    250:
    IIPDISEPGT | WKISARFSDG | LESNRSTHFE | VKKYVLPNFE | VKLTPWKPYI | 
    300:
    LTVPSYREEI | QLDVQARYVY | GKPVQGVAYT | RFALMDEQGK | KSFLRGLETQ | 
    350:
    TKLVEGQTHI | SISRDQFQAA | LGKVNTEIGD | LEGLRLYAAV | AVIESPGGEM | 
    400:
    EEAELTSWPF | VSSAFSLDLS | HTKQHLVPGA | PFLLQALVRE | MSGSEASDVP | 
    450:
    VKVSATLLSG | SDSKVLDFQQ | NTNGIGQVSF | SIHVPPTITE | LRLLVSAGSL | 
    500:
    YPAVAKLTVQ | APPSRGPGFL | SIEPLDLRSP | RVGDTFVLSL | RTVGIPMPTF | 
    550:
    SHYYYMIISR | GQIMAMSREP | RRALTSISVL | VDHHLAPSFY | FVAYFYHQGL | 
    600:
    PVANSLLINV | QPGDCEGKLE | LKVDGAKEYR | NGDSMKLQLQ | TDSEALVALG | 
    650:
    AVDTALYAVG | GRSHKPLDMS | KVFEVMNSYN | LGCGPGGGDD | ALQVFQTAGL | 
    700:
    AFSDGDRLTQ | TKENLSCPKE | KKSRQKRNVN | FQKAISEKLG | QYSSPDTKRC | 
    750:
    CQDGMTKLPM | ARTCEQRAAR | VPQPACREPF | LSCCKFAEDL | RRNQTRSQAG | 
    800:
    LARAQDMLQE | EDLIDEDDIL | VRSFFPENWL | WRVEPVDRSK | LLTVWLPDSL | 
    850:
    TTWEIHGVSL | SKSKGLCVAK | PTRVRVFREF | HLHLRLPISV | RRFEQLELRP | 
    900:
    VLYNYLSEDV | TVSVHVSPVE | GLCLAGGGLL | AQQVSVPAGS | ARPVAFSVVP | 
    950:
    TAAASIPLKV | VARGSFTIGD | AVSKILQIEK | EGAIHREEIV | YNLDPLNNLG | 
    1000:
    RSLEIPGSSD | PNVIPDGDFS | SFVRVTASEP | LETLGSEGAL | SPGGVASLLR | 
    1050:
    LPRGCAEQTM | IYLAPTLTAS | HYLDRTEQWS | KLPPETKDHA | VDLIQKGHMR | 
    1100:
    IQQFRKKDGS | FGAWLHRDSS | TWLTAFVLKI | LSLAQEQIGD | SPEKLQETAG | 
    1150:
    WLLGQQLDDG | SFHDPCPVIH | RGMQGGLVGT | DETVALTAFV | VIALHHGLAV | 
    1200:
    FQDENSQQLK | KRVEASITKA | NSFLGQKASA | GLLGAHASAI | TAYALTLTKA | 
    1250:
    SEDLQNVAHN | SLMAMAEETG | ENLYWGSAIG | SQDNVVSSTP | APRNPSEPVP | 
    1300:
    QAPALWIETT | AYGLLHLLLR | EGKGEMADKV | ATWLTHQGSF | QGGFRSTQDT | 
    1350:
    VVTLDALSAY | WIASHTTEEK | ALNVTLSSMG | RNGYKSHLLQ | LNNHQVKGLE | 
    1400:
    EELKFSLGST | INVKVGGNSK | GTLKILRTYN | VLDMKNTTCQ | DLRIEVTVTG | 
    1450:
    YVEYTREANE | DYEYDYDMPA | ADDPSVHSQP | VTPLQLFEGR | RSRRRREAPK | 
    1500:
    AADEQESRVQ | YTVCIWRNGN | LGLSGMAIAD | ITLLSGFQAL | RADLEKLTSL | 
    1550:
    SDRYVSHFET | DGPHVLLYFD | SVPTTRECVG | FGALQEVAVG | LVQPASAVLY | 
    1600:
    DYYSPDHKCS | VFYAAPTKSK | LLSTLCSADV | CQCAEGKCPR | QRRSLERGVE | 
    1650:
    DKDGYRMKFA | CYYPRVEYGF | QVKVLREDSR | AAFRLFETKI | TQVLHFTKDA | 
    1700:
    KASIGQTRNF | LVRASCRLRL | EPSKEYLIMG | MDGVTSDLKG | DPQYLLDSNT | 
    1737:
    WIEEMPSERL | CRSTRQRAAC | GQLNDFLQEY | SSQGCQV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Complement C4
    Cat.:
    E0389b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Complement C4
    Cat.:
    E0389r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Complement C4
    Cat.:
    U0389b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Complement C4
    Cat.:
    U0389r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Complement C4
    Polyclonal Antibody for Rat Complement C4
    Cat.:
    P0389Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Complement C4
    Monoclonal Antibody for Rat Complement C4
    Protein for Rat Complement C4
    Protein for Rat Complement C4

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Substrate recognition by zymogen and activated forms of mannose-binding protein-associated serine proteases."
      Chen C.-B. , Wallis R.
      Submitted (2002-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
    2. 2.
      "Physical mapping of the major histocompatibility complex class II and class III regions of the rat."
      Walter L. , Hurt P. , Himmelbauer H. , Sudbrak R. , Guenther E.
      Immunogenetics54:268-275(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-266
      strain: Brown Norway.
    3. 3.
      "Complement C4 protein expression by rat hepatic stellate cells."
      Fimmel C.J. , Brown K.E. , O'Neill R. , Kladney R.D.
      J. Immunol.157:2601-2609(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1656-1737;INDUCTION
      strain: Sprague-Dawley.
      tissue: Hepatic stellate cell.
    4. 4.
      "Structural characterization of the C4a anaphylatoxin from rat."
      Cui L.-X. , Ferreri K. , Hugli T.E.
      Mol. Immunol.25:663-671(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 678-753
    5. 5.
      "Characterization of rat anaphylatoxins C4a and C5a."
      Cui L.-X. , Ferreri K. , Hugli T.E.
      Fed. Proc.44:991-991(1985)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 678-753
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