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Index > Protein center > CFL2(Gene name) > Human
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  • CFL2 (Gene name),
  • Cofilin-2 (Protein name ),  COF2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    CFL2;
    Protein name:
    Cofilin-2;
    Alternative:
    Cofilin, muscle isoform;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
    Subcellular Location:
    Nucleus matrix Cytoplasm cytoskeleton
    Protein Attributes:
    Sequence length:
    166
    Sequence:
    50:
    MASGVTVNDE | VIKVFNDMKV | RKSSTQEEIK | KRKKAVLFCL | SDDKRQIIVE | 
    100:
    EAKQILVGDI | GDTVEDPYTS | FVKLLPLNDC | RYALYDATYE | TKESKKEDLV | 
    150:
    FIFWAPESAP | LKSKMIYASS | KDAIKKKFTG | IKHEWQVNGL | DDIKDRSTLG | 
    166:
    EKLGGNVVVS | LEGKPL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    UniGene:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cofilin-2
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    E1861m
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    ELISA Kit for Human Cofilin-2
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    ELISA Kit for Human Cofilin-2
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    ELISA Kit for Human Cofilin-2
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    E1861h
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    ELISA Kit for Human Cofilin-2
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    E1861b
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    96T
    CLIA Kit for Human Cofilin-2
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    U1861m
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    96T
    CLIA Kit for Human Cofilin-2
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    U1861c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Cofilin-2
    Cat.:
    U1861b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Cofilin-2
    Cat.:
    U1861p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Cofilin-2
    Cat.:
    U1861h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Cofilin-2
    Polyclonal Antibody for Human Cofilin-2
    Polyclonal Antibody for Human Cofilin-2
    Cat.:
    P1861Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cofilin-2
    Polyclonal Antibody for Human Cofilin-2
    Cat.:
    P1861Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cofilin-2
    Monoclonal Antibody for Human Cofilin-2
    Monoclonal Antibody for Human Cofilin-2
    Monoclonal Antibody for Human Cofilin-2
    Monoclonal Antibody for Human Cofilin-2
    Protein for Human Cofilin-2
    Protein for Human Cofilin-2
    Protein for Human Cofilin-2
    Protein for Human Cofilin-2
    Protein for Human Cofilin-2

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    References
    1. 1.
      "Isolation of two isoforms of human cofilin cDNA."
      Jin J. , Li G. , Hu S. , Li W. , Yuan J. , Qiang B.
      Submitted (1999-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CFL2A AND CFL2B)
    2. 2.
      "Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle."
      Thirion C. , Stucka R. , Mendel B. , Gruhler A. , Jaksch M. , Nowak K.J. , Binz N. , Laing N.G. , Lochmuller H.
      Eur. J. Biochem.268:3473-3482(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS CFL2A AND CFL2B)
      tissue: Bone marrow.
      tissue: Placenta.
      tissue: Skeletal muscle.
    6. 6.
      Bienvenut W.V. , Calvo F. , Kolch W.
      Submitted (2008-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21; 35-92; 96-112; 115-125 AND 153-166;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Cervix carcinoma.
    7. 7.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-47
    14. 14.
      "Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2."
      Agrawal P.B. , Greenleaf R.S. , Tomczak K.K. , Lehtokari V.-L. , Wallgren-Pettersson C. , Wallefeld W. , Laing N.G. , Darras B.T. , Maciver S.K. , Dormitzer P.R. , Beggs A.H.
      Am. J. Hum. Genet.80:162-167(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NEM7 THR-35;CHARACTERIZATION OF VARIANT NEM7 THR-35
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