COMP ELISA Kit for Human(Homo sapiens) | EIAab.comCOMP ELISA Kit for Human(Homo sapiens)

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COMP (Gene name),

Cartilage oligomeric matrix protein (Protein name ), COMP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

COMP;

Protein name:

Cartilage oligomeric matrix protein(COMP);

Alternative:

Thrombospondin-5(TSP5);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+). Interacts with MATN1, MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX, and interaction with these collagens is dependent on the presence of zinc ions. Interacts with ADAMTS12. Interacts with ITGA7.

Function:

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

757

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

757:

THQLRQA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.1584

SMR:

P49747

MIM:

132400

Pfam:

PF11598

STRING:

9606.ENSP00000222271

KEGG:

hsa:1311

String:

P49747

Uniprot:

P49747

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ELISA Kit for Human COMP

Cat.:

E1197h

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96T

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ELISA Kit for Human COMP

Cat.:

E1197m

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96T

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ELISA Kit for Human COMP

Cat.:

E1197r

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96T

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ELISA Kit for Human COMP

Cat.:

E1197b

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96T

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CLIA Kit for Human COMP

Cat.:

U1197r

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Packing:

96T

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CLIA Kit for Human COMP

Cat.:

U1197m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human COMP

Cat.:

U1197h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human COMP

Cat.:

U1197b

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Packing:

96T

Polyclonal Antibody for Human COMP

Cat.:

P1197Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human COMP

Cat.:

P1197Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human COMP

Cat.:

P1197Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human COMP

Protein for Human COMP

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Characterization of human and mouse cartilage oligomeric matrix protein."
Newton G. , Weremowicz S. , Morton C.C. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Lawler J.
Genomics24:435-439(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ASP-50; TRP-51; GLY-109; GLY-224 AND PRO-285
tissue: Cartilage.
2.

"Human comp cDNA with 5 SNIPs."
Hashimoto Y. , Mori H.
Submitted (2002-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ASP-50; TRP-51; GLY-109; GLY-224 AND PRO-285
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
4.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Ovary.
7.

"Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene."
Briggs M.D. , Hoffman S.M.G. , King L.M. , Olsen A.S. , Mohrenweiser H. , Leroy J.G. , Mortier G.R. , Rimoin D.L. , Lachman R.S. , Gaines E.S. , Cekleniak J.A. , Knowlton R.G. , Cohn D.H.
Nat. Genet.10:330-336(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 326-344;VARIANT EDM1 TYR-342;VARIANT PSACH ARG-328
8.

"Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes."
Chen H. , Deere M. , Hecht J.T. , Lawler J.
J. Biol. Chem.275:26538-26544(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 80-89;SUBUNIT;CALCIUM-BINDING;CHARACTERIZATION OF VARIANT PSACH ASP-469 DEL
9.

"Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX."
Thur J. , Rosenberg K. , Nitsche D.P. , Pihlajamaa T. , Ala-Kokko L. , Heinegaard D. , Paulsson M. , Maurer P.
J. Biol. Chem.276:6083-6092(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE;CALCIUM-BINDING;INTERACTION WITH COLLAGEN I; COLLAGEN II AND COLLAGEN IX;CHARACTERIZATION OF VARIANT PSACH ASP-469 DEL;CHARACTERIZATION OF VARIANT EDM1 TYR-361
10.

"Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin."
Di Cesare P.E. , Chen F.S. , Moergelin M. , Carlson C.S. , Leslie M.P. , Perris R. , Fang C.
Matrix Biol.21:461-470(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FN1
11.

"Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias."
Mann H.H. , Oezbek S. , Engel J. , Paulsson M. , Wagener R.
J. Biol. Chem.279:25294-25298(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MATN1; MATN3 AND MATN4
12.

"Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins."
Chen F.-H. , Thomas A.O. , Hecht J.T. , Goldring M.B. , Lawler J.
J. Biol. Chem.280:32655-32661(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ITGB3 AND ITGA5
13.

"Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis."
Koelling S. , Clauditz T.S. , Kaste M. , Miosge N.
Arthritis Res. Ther.8:R56-R56(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
14.

"ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein."
Liu C.-J. , Kong W. , Xu K. , Luan Y. , Ilalov K. , Sehgal B. , Yu S. , Howell R.D. , Di Cesare P.E.
J. Biol. Chem.281:15800-15808(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADAMTS12
15.

"Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan."
Chen F.-H. , Herndon M.E. , Patel N. , Hecht J.T. , Tuan R.S. , Lawler J.
J. Biol. Chem.282:24591-24598(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACAN; HEPARIN; HEPARAN SULFATE AND CHONDROITIN SULFATE
16.

"Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins."
Gagarina V. , Carlberg A.L. , Pereira-Mouries L. , Hall D.J.
J. Biol. Chem.283:648-659(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAINS
17.

"The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding."
Tan K. , Duquette M. , Joachimiak A. , Lawler J.
FASEB J.23:2490-2501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) OF 225-757 IN COMPLEX WITH CALCIUM IONS;DISULFIDE BONDS;GLYCOSYLATION AT ASN-742
18.

"Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia."
Hecht J.T. , Nelson L.D. , Crowder E. , Wang Y. , Elder F.F.B. , Harrison W.R. , Francomano C.A. , Prange C.K. , Lennon G.G. , Deere M. , Lawler J.
Nat. Genet.10:325-329(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PSACH SER-459 DEL; TYR-468 AND TYR-472
19.

"Multiple epiphyseal dysplasia, ribbing type: a novel point mutation in the COMP gene in a South African family."
Ballo R. , Briggs M.D. , Cohn D.H. , Knowlton R.G. , Beighton P.H. , Ramesar R.S.
Am. J. Med. Genet.68:396-400(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EDM1 LYS-523
20.

"Multiple epiphyseal dysplasia and pseudoachondroplasia due to novel mutations in the calmodulin-like repeats of cartilage oligomeric matrix protein."
Susic S. , McGrory J. , Ahier J. , Cole W.G.
Clin. Genet.51:219-224(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EDM1 SER-371;VARIANT PSACH 513-VAL--LYS-516 DEL
21.

"Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum."
Briggs M.D. , Mortier G.R. , Cole W.G. , King L.M. , Golik S.S. , Bonaventure J. , Nuytinck L. , de Paepe A. , Leroy J.G. , Biesecker L. , Lipson M. , Wilcox W.R. , Lachman R.S. , Rimoin D.L. , Knowlton R.G. , Cohn D.H.
Am. J. Hum. Genet.62:311-319(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PSACH;VARIANTS EDM1 SER-453 AND ARG-585
22.

"Novel and recurrent COMP (cartilage oligomeric matrix protein) mutations in pseudoachondroplasia and multiple epiphyseal dysplasia."
Ikegawa S. , Ohashi H. , Nishimura G. , Kim K.C. , Sannohe A. , Kimizuka M. , Fukushima Y. , Nagai T. , Nakamura Y.
Hum. Genet.103:633-638(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PSACH AND EDM1
23.

"Identification of five novel mutations in cartilage oligomeric matrix protein gene in pseudoachondroplasia and multiple epiphyseal dysplasia."
Loughlin J. , Irven C. , Mustafa Z. , Briggs M.D. , Carr A. , Lynch S.-A. , Knowlton R.G. , Cohn D.H. , Sykes B.
Hum. Mutat. Suppl.1:S10-S17(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PSACH ARG-328; ASP-372 DEL; 391-PRO--ASP-394 DELINS VAL; ARG-440; SER-459 DEL; TYR-468; ASP-469 DEL AND TYR-472;VARIANTS EDM1 TYR-342; TYR-361; 367-ARG-GLY-368 DEL AND TYR-408
24.

"Pseudoachondroplasia due to the substitution of the highly conserved Asp482 by Gly in the seventh calmodulin-like repeat of cartilage oligomeric matrix protein."
Susic S. , Ahier J. , Cole W.G.
Hum. Mutat. Suppl.1:S125-S127(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PSACH GLY-482
25.

"Double heterozygosity for pseudoachondroplasia and spondyloepiphyseal dysplasia congenita."
Unger S. , Koerkkoe J. , Krakow D. , Lachman R.S. , Rimoin D.L. , Cohn D.H.
Am. J. Med. Genet.104:140-146(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PSACH ARG-348
26.

"Novel mutation in exon 18 of the cartilage oligomeric matrix protein gene causes a severe pseudoachondroplasia."
Mabuchi A. , Haga N. , Ikeda T. , Manabe N. , Ohashi H. , Takatori Y. , Nakamura K. , Ikegawa S.
Am. J. Med. Genet.104:135-139(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PSACH ASP-719
27.

"A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity."
Czarny-Ratajczak M. , Lohiniva J. , Rogala P. , Kozlowski K. , Peraelae M. , Carter L. , Spector T.D. , Kolodziej L. , Seppaenen U. , Glazar R. , Krolewski J. , Latos-Bielenska A. , Ala-Kokko L.
Am. J. Hum. Genet.69:969-980(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EDM1 ARG-276; ALA-420 AND MET-585
28.

"Pseudoachondroplasia and multiple epiphyseal dysplasia: A 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution."
Jackson G.C. , Mittaz-Crettol L. , Taylor J.A. , Mortier G.R. , Spranger J. , Zabel B. , Le Merrer M. , Cormier-Daire V. , Hall C.M. , Offiah A. , Wright M.J. , Savarirayan R. , Nishimura G. , Ramsden S.C. , Elles R. , Bonafe L. , Superti-Furga A. , Unger S. , more...
Hum. Mutat.33:144-157(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PSACH SER-234; GLY-290; ARG-299; TYR-326; 341-GLU-ASP-342 DEL; 350-ASN--ASP-372 DEL; VAL-378; ARG-387; 402-GLY--GLY-404 DELINS VAL-CYS; ARG-440; ASN-446; SER-448; ASP-473 DEL; HIS-473; ASN-475; GLY-482; GLY-507; GLY-511; GLY-515; ILE-529; ARG-585 AND SER-719;VARIANTS EDM1 GLU-167; ARG-276; LEU-298; ASP-311; GLY-317; GLY-326; PHE-348; SER-371; TYR-371; ASN-374; ASN-376; ASN-385; ASP-385 DEL; TYR-385; HIS-397; ARG-404; TYR-410; LYS-415; GLU-427; 430-CYS--SER-432 DELINS LEU-TRP-CYS; GLU-457 DEL; ASP-473 INS; ASP-501; LYS-523; MET-585; PRO-718 AND TRP-718;VARIANT ARG-756

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