Gene name:
CORIN (CRN;TMPRSS10) ;
Protein name:
Atrial natriuretic peptide-converting enzyme ;
Alternative:
Heart-specific serine proteinase ATC2 ;Corin ;Transmembrane protease serine 10 ;Pro-ANP-converting enzyme ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Serine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide.
Subcellular Location:
Cell membrane
Single-pass type II membrane protein
Protein Attributes:
50:
MKQSPALAPE | ERCRRAGSPK | PVLRADDNNM | GNGCSQKLAT | ANLLRFLLLV |
100:
LIPCICALVL | LLVILLSYVG | TLQKVYFKSN | GSEPLVTDGE | IQGSDVILTN |
150:
TIYNQSTVVS | TAHPDQHVPA | WTTDASLPGD | QSHRNTSACM | NITHSQCQML |
200:
PYHATLTPLL | SVVRNMEMEK | FLKFFTYLHR | LSCYQHIMLF | GCTLAFPECI |
250:
IDGDDSHGLL | PCRSFCEAAK | EGCESVLGMV | NYSWPDFLRC | SQFRNQTESS |
300:
NVSRICFSPQ | QENGKQLLCG | RGENFLCASG | ICIPGKLQCN | GYNDCDDWSD |
350:
EAHCNCSENL | FHCHTGKCLN | YSLVCDGYDD | CGDLSDEQNC | DCNPTTEHRC |
400:
GDGRCIAMEW | VCDGDHDCVD | KSDEVNCSCH | SQGLVECRNG | QCIPSTFQCD |
450:
GDEDCKDGSD | EENCSVIQTS | CQEGDQRCLY | NPCLDSCGGS | SLCDPNNSLN |
500:
NCSQCEPITL | ELCMNLPYNS | TSYPNYFGHR | TQKEASISWE | SSLFPALVQT |
550:
NCYKYLMFFS | CTILVPKCDV | NTGEHIPPCR | ALCEHSKERC | ESVLGIVGLQ |
600:
WPEDTDCSQF | PEENSDNQTC | LMPDEYVEEC | SPSHFKCRSG | QCVLASRRCD |
650:
GQADCDDDSD | EENCGCKERD | LWECPSNKQC | LKHTVICDGF | PDCPDYMDEK |
700:
NCSFCQDDEL | ECANHACVSR | DLWCDGEADC | SDSSDEWDCV | TLSINVNSSS |
750:
FLMVHRAATE | HHVCADGWQE | ILSQLACKQM | GLGEPSVTKL | IQEQEKEPRW |
800:
LTLHSNWESL | NGTTLHELLV | NGQSCESRSK | ISLLCTKQDC | GRRPAARMNK |
850:
RILGGRTSRP | GRWPWQCSLQ | SEPSGHICGC | VLIAKKWVLT | VAHCFEGREN |
900:
AAVWKVVLGI | NNLDHPSVFM | QTRFVKTIIL | HPRYSRAVVD | YDISIVELSE |
950:
DISETGYVRP | VCLPNPEQWL | EPDTYCYITG | WGHMGNKMPF | KLQEGEVRII |
1000:
SLEHCQSYFD | MKTITTRMIC | AGYESGTVDS | CMGDSGGPLV | CEKPGGRWTL |
1042:
FGLTSWGSVC | FSKVLGPGVY | SNVSYFVEWI | KRQIYIQTFL | LN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human Atrial natriuretic peptide-converting enzyme
ELISA Kit for Human Atrial natriuretic peptide-converting enzyme
ELISA Kit for Human Atrial natriuretic peptide-converting enzyme
CLIA Kit for Human Atrial natriuretic peptide-converting enzyme
CLIA Kit for Human Atrial natriuretic peptide-converting enzyme
CLIA Kit for Human Atrial natriuretic peptide-converting enzyme
Polyclonal Antibody for Human Atrial natriuretic peptide-converting enzyme
Polyclonal Antibody for Human Atrial natriuretic peptide-converting enzyme
Polyclonal Antibody for Human Atrial natriuretic peptide-converting enzyme
Monoclonal Antibody for Human Atrial natriuretic peptide-converting enzyme
Monoclonal Antibody for Human Atrial natriuretic peptide-converting enzyme
Monoclonal Antibody for Human Atrial natriuretic peptide-converting enzyme
Protein for Human Atrial natriuretic peptide-converting enzyme
Protein for Human Atrial natriuretic peptide-converting enzyme
Protein for Human Atrial natriuretic peptide-converting enzyme
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANTS TYR-13 AND ARG-525
tissue :
Heart .
2.
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W.
,
Graves T.A.
,
Fulton R.S.
,
Fulton L.A.
,
Pepin K.H.
,
Minx P.
,
Wagner-McPherson C.
,
Layman D.
,
Wylie K.
,
Sekhon M.
,
Becker M.C.
,
Fewell G.A.
,
Delehaunty K.D.
,
Miner T.L.
,
Nash W.E.
,
Kremitzki C.
,
Oddy L.
,
Du H.
,
Sun H.
,
Bradshaw-Cordum H.
,
Ali J.
,
Carter J.
,
Cordes M.
,
Harris A.
,
Isak A.
,
van Brunt A.
,
Nguyen C.
,
Du F.
,
Courtney L.
,
Kalicki J.
,
Ozersky P.
,
Abbott S.
,
Armstrong J.
,
Belter E.A.
,
Caruso L.
,
Cedroni M.
,
Cotton M.
,
Davidson T.
,
Desai A.
,
Elliott G.
,
Erb T.
,
Fronick C.
,
Gaige T.
,
Haakenson W.
,
Haglund K.
,
Holmes A.
,
Harkins R.
,
Kim K.
,
Kruchowski S.S.
,
Strong C.M.
,
Grewal N.
,
Goyea E.
,
Hou S.
,
Levy A.
,
Martinka S.
,
Mead K.
,
McLellan M.D.
,
Meyer R.
,
Randall-Maher J.
,
Tomlinson C.
,
Dauphin-Kohlberg S.
,
Kozlowicz-Reilly A.
,
Shah N.
,
Swearengen-Shahid S.
,
Snider J.
,
Strong J.T.
,
Thompson J.
,
Yoakum M.
,
Leonard S.
,
Pearman C.
,
Trani L.
,
Radionenko M.
,
Waligorski J.E.
,
Wang C.
,
Rock S.M.
,
Tin-Wollam A.-M.
,
Maupin R.
,
Latreille P.
,
Wendl M.C.
,
Yang S.-P.
,
Pohl C.
,
Wallis J.W.
,
Spieth J.
,
Bieri T.A.
,
Berkowicz N.
,
Nelson J.O.
,
Osborne J.
,
Ding L.
,
Meyer R.
,
Sabo A.
,
Shotland Y.
,
Sinha P.
,
Wohldmann P.E.
,
Cook L.L.
,
Hickenbotham M.T.
,
Eldred J.
,
Williams D.
,
Jones T.A.
,
She X.
,
Ciccarelli F.D.
,
Izaurralde E.
,
Taylor J.
,
Schmutz J.
,
Myers R.M.
,
Cox D.R.
,
Huang X.
,
McPherson J.D.
,
Mardis E.R.
,
Clifton S.W.
,
Warren W.C.
,
Chinwalla A.T.
,
Eddy S.R.
,
Marra M.A.
,
Ovcharenko I.
,
Furey T.S.
,
Miller W.
,
Eichler E.E.
,
Bork P.
,
Suyama M.
,
Torrents D.
,
Waterston R.H.
,
Wilson R.K.
more...
Nature434:724-731(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS TYR-13 AND ARG-525
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 734-1040
tissue :
Heart .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS OF SER-985
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACTIVATION;MUTAGENESIS OF ARG-801 AND SER-985;BIOPHYSICOCHEMICAL PROPERTIES
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING;GLYCOSYLATION;DISULFIDE BONDS
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;PROTEOLYTIC PROCESSING;MUTAGENESIS OF ARG-134; ARG-164; ARG-180; ARG-213; ARG-239; ARG-244; ARG-427; ARG-801 AND SER-985
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORMS 1 AND 2);FUNCTION;SUBCELLULAR LOCATION;GLYCOSYLATION;MUTAGENESIS OF ASP-26 AND MET-30
11.
"Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy."
Cui Y.
,
Wang W.
,
Dong N.
,
Lou J.
,
Srinivasan D.K.
,
Cheng W.
,
Huang X.
,
Liu M.
,
Fang C.
,
Peng J.
,
Chen S.
,
Wu S.
,
Liu Z.
,
Dong L.
,
Zhou Y.
,
Wu Q.
Nature484:246-250(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INVOLVEMENT IN PEE5;TISSUE SPECIFICITY;VARIANTS PEE5 GLU-317 AND GLY-472
12.
"An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss."
Guipponi M.
,
Toh M.-Y.
,
Tan J.
,
Park D.
,
Hanson K.
,
Ballana E.
,
Kwong D.
,
Cannon P.Z.F.
,
Wu Q.
,
Gout A.
,
Delorenzi M.
,
Speed T.P.
,
Smith R.J.H.
,
Dahl H.-H.M.
,
Petersen M.
,
Teasdale R.D.
,
Estivill X.
,
Park W.J.
,
Scott H.S.
more...
Hum. Mutat.29:130-141(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ARG-525