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Index > Protein center > CEP135(Gene name) > Human
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  • CEP135 (Gene name),
  • Centrosomal protein of 135 kDa (Protein name ),  CP135_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CEP135(CEP4;KIAA0635);
    Protein name:
    Centrosomal protein of 135 kDa(Cep135);
    Alternative:
    Centrosomal protein 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with DCTN2 (By similarity). Interacts with CEP250.
    Function:
    Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole.
    Subcellular Location:
    Cytoplasm cytoskeleton centrosome centriole During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
    Protein Attributes:
    Sequence length:
    1140
    Sequence:
    50:
    MTTAVERKYI | NIRKRLDQLG | YRQTLTVECL | PLVEKLFSDL | VHTTESLRQS | 
    100:
    KLSAVKAEKE | SANFDFVLEP | YKLENARLSR | ENNELYLELM | KLREHSDQHV | 
    150:
    KELKTSLKKC | ARETADLKFL | NNQYAHKLKL | LEKESKAKNE | RIQQLQEKNL | 
    200:
    HAVVQTPGGK | KRSIAFRRQR | MQIDEPVPPS | EVSSYPVPQP | DDPYIADLLQ | 
    250:
    VADNRIQELQ | QEVHQLQEKL | AMMESGVRDY | SKQIELRERE | IERLSVALDG | 
    300:
    GRSPDVLSLE | SRNKTNEKLI | AHLNIQVDFL | QQANKDLEKR | IRELMETKET | 
    350:
    VTSEVVNLSN | KNEKLCQELT | EIDQLAQQLE | RHKEEVLETA | DKELGEAKKE | 
    400:
    IKRKLSEMQD | LEETMAKLQL | ELNLCQKEKE | RLSDELLVKS | DLETVVHQLE | 
    450:
    QEKQRLSKKV | ESFAVTERQL | TLEVERMRLE | HGIKRRDRSP | SRLDTFLKGI | 
    500:
    EEERDYYKKE | LERLQHIIQR | RSCSTSYSAR | EKSSIFRTPE | KGDYNSEIHQ | 
    550:
    ITRERDELQR | MLERFEKYME | DIQSNVKLLT | AERDKLSVLY | NEAQEELSAL | 
    600:
    RKESTQTTAP | HNIVSLMEKE | KELALSDLRR | IMAEKEALRE | KLEHIEEVSL | 
    650:
    FGKSELEKTI | EHLTCVNHQL | ESEKYELKSK | VLIMKETIES | LENKLKVQAQ | 
    700:
    KFSHVAGDSS | HQKTEVNSLR | IVNEQLQRSV | DDYQHRLSIK | RGELESAQAQ | 
    750:
    IKILEEKIDE | LNLKMTSQDE | EAHVMKKTIG | VIDKEKDFLQ | ETVDEKTEKI | 
    800:
    ANLQENLANK | EKAVAQMKIM | ISECESSVNQ | LKETLVNRDR | EINSLRRQLD | 
    850:
    AAHKELDEVG | RSREIAFKEN | RRLQDDLATM | ARENQEISLE | LEAAVQEKEE | 
    900:
    MKSRVHKYIT | EVSRWESLMA | AKEKENQDLL | DRFQMLHNRA | EDWEVKAHQA | 
    950:
    EGESSSVRLE | LLSIDTERRH | LRERVELLEK | EIQEHINAHH | AYESQISSMA | 
    1000:
    KAMSRLEEEL | RHQEDEKATV | LNDLSSLREL | CIKLDSGKDI | MTQQLNSKNL | 
    1050:
    EFERVVVELE | NVKSESDLLK | KQLSNERHTV | KNLESLLATN | RDKEFHSHLT | 
    1100:
    SHEKDTEIQL | LKEKLTLSES | KLTSQSRENT | MLRAKVAQLQ | TDYDALKRQI | 
    1140:
    STERYERERA | IQEMRRHGLA | TPPLSSTLRS | PSHSPEHRNV | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cep135
    ELISA Kit for Human Cep135
    CLIA Kit for Human Cep135
    CLIA Kit for Human Cep135
    Polyclonal Antibody for Human Cep135
    Polyclonal Antibody for Human Cep135
    Monoclonal Antibody for Human Cep135
    Monoclonal Antibody for Human Cep135
    Protein for Human Cep135
    Protein for Human Cep135

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Placenta.
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    4. 4.
      "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K. , Nagase T. , Suyama M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 277-1140 (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "Proteomic characterization of the human centrosome by protein correlation profiling."
      Andersen J.S. , Wilkinson C.J. , Mayor T. , Mortensen P. , Nigg E.A. , Mann M.
      Nature426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION (ISOFORM 1);SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Lymphoblast.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    7. 7.
      "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization."
      Kim K. , Lee S. , Chang J. , Rhee K.
      Exp. Cell Res.314:3692-3700(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CEP250
    8. 8.
      "A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function."
      Hussain M.S. , Baig S.M. , Neumann S. , Nurnberg G. , Farooq M. , Ahmad I. , Alef T. , Hennies H.C. , Technau M. , Altmuller J. , Frommolt P. , Thiele H. , Noegel A.A. , Nurnberg P.
      Am. J. Hum. Genet.90:871-878(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MCPH8
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