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Index > Protein center > CYP21(Gene name) > Bovine
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  • CYP21 (Gene name),
  • Steroid 21-hydroxylase (Protein name ),  CP21A_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CYP21(CYP21A1;CYP21A2);
    Protein name:
    Steroid 21-hydroxylase;
    Alternative:
    Cytochrome P-450c21;21-OHase;Cytochrome P450 XXI;Cytochrome P450 21;Cytochrome P450-C21;
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
    Subcellular Location:
    Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    496
    Sequence:
    50:
    MVLAGLLLLL | TLLAGAHLLW | GRWKLRNLHL | PPLVPGFLHL | LQPNLPIHLL | 
    100:
    SLTQKLGPVY | RLRLGLQEVV | VLNSKRTIEE | AMIRKWVDFA | GRPQIPSYKL | 
    150:
    VSQRCQDISL | GDYSLLWKAH | KKLTRSALLL | GTRSSMEPWV | DQLTQEFCER | 
    200:
    MRVQAGAPVT | IQKEFSLLTC | SIICYLTFGN | KEDTLVHAFH | DCVQDLMKTW | 
    250:
    DHWSIQILDM | VPFLRFFPNP | GLWRLKQAIE | NRDHMVEKQL | TRHKESMVAG | 
    300:
    QWRDMTDYML | QGVGRQRVEE | GPGQLLEGHV | HMSVVDLFIG | GTETTASTLS | 
    350:
    WAVAFLLHHP | EIQRRLQEEL | DRELGPGASC | SRVTYKDRAR | LPLLNATIAE | 
    400:
    VLRLRPVVPL | ALPHRTTRPS | SIFGYDIPEG | MVVIPNLQGA | HLDETVWEQP | 
    450:
    HEFRPDRFLE | PGANPSALAF | GCGARVCLGE | SLARLELFVV | LLRLLQAFTL | 
    496:
    LPPPVGALPS | LQPDPYCGVN | LKVQPFQVRL | QPRGVEAGAW | ESASAQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine Steroid 21-hydroxylase
    Cat.:
    E1557d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Steroid 21-hydroxylase
    Cat.:
    E1557m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Steroid 21-hydroxylase
    Cat.:
    E1557r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Steroid 21-hydroxylase
    Cat.:
    E1557b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Bovine Steroid 21-hydroxylase
    Cat.:
    E1557p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Steroid 21-hydroxylase
    Cat.:
    U1557p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Steroid 21-hydroxylase
    Cat.:
    U1557r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Steroid 21-hydroxylase
    Cat.:
    U1557b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Steroid 21-hydroxylase
    Cat.:
    U1557d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Steroid 21-hydroxylase
    Cat.:
    U1557m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Bovine Steroid 21-hydroxylase
    Polyclonal Antibody for Bovine Steroid 21-hydroxylase
    Polyclonal Antibody for Bovine Steroid 21-hydroxylase
    Cat.:
    P1557Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Steroid 21-hydroxylase
    Cat.:
    P1557Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Steroid 21-hydroxylase
    Monoclonal Antibody for Bovine Steroid 21-hydroxylase
    Monoclonal Antibody for Bovine Steroid 21-hydroxylase
    Monoclonal Antibody for Bovine Steroid 21-hydroxylase
    Monoclonal Antibody for Bovine Steroid 21-hydroxylase
    Monoclonal Antibody for Bovine Steroid 21-hydroxylase
    Protein for Bovine Steroid 21-hydroxylase
    Protein for Bovine Steroid 21-hydroxylase
    Protein for Bovine Steroid 21-hydroxylase
    Protein for Bovine Steroid 21-hydroxylase
    Protein for Bovine Steroid 21-hydroxylase

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Structure of a bovine gene for P-450c21 (steroid 21-hydroxylase) defines a novel cytochrome P-450 gene family."
      Chung B. , Matteson K.J. , Miller W.L.
      Proc. Natl. Acad. Sci. U.S.A.83:4243-4247(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Structural analysis of cloned cDNA for mRNA of microsomal cytochrome P-450(C21) which catalyzes steroid 21-hydroxylation in bovine adrenal cortex."
      Yoshioka H. , Morohashi K. , Sogawa K. , Yamane M. , Kominami S. , Takemori S. , Okada Y. , Omura T. , Fujii-Kuriyama Y.
      J. Biol. Chem.261:4106-4109(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Bovine steroid 21-hydroxylase: regulation of biosynthesis."
      John M.E. , Okamura T. , Dee A. , Adler B. , John M.C. , White P.C. , Simpson E.R. , Waterman M.R.
      Biochemistry25:2846-2853(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-496
    4. 4.
      "Partial amino acid sequences of two mitochondrial and two microsomal cytochrome P-450's from adrenal cortex."
      Ogishima T. , Okada Y. , Kominami S. , Takemori S. , Omura T.
      J. Biochem.94:1711-1714(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-15
    5. 5.
      "Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants."
      Zhao B. , Lei L. , Kagawa N. , Sundaramoorthy M. , Banerjee S. , Nagy L.D. , Guengerich F.P. , Waterman M.R.
      J. Biol. Chem.287:10613-10622(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH HEME AND 17-HYDROXYPROGESTERONE;FUNCTION;COFACTOR;CATALYTIC ACTIVITY
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