CYP2C19 ELISA Kit for Human(Homo sapiens) | EIAab.comCYP2C19 ELISA Kit for Human(Homo sapiens) | EIAab.com

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CYP2C19 (Gene name),

Cytochrome P450 2C19 (Protein name ), CP2CJ_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

CYP2C19;

Protein name:

Cytochrome P450 2C19;

Alternative:

1.14.13.48;(S)-limonene 6-monooxygenase);1.14.13.80;(R)-limonene 6-monooxygenase);CYPIIC17;1.14.13.49;(S)-limonene 7-monooxygenase);Cytochrome P450-11A;CYPIIC19;Mephenytoin 4-hydroxylase;Cytochrome P450-254C;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.

Subcellular Location:

Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

490

Sequence:

50:

MDPFVVLVLC | LSCLLLLSIW | RQSSGRGKLP | PGPTPLPVIG | NILQIDIKDV |

100:

SKSLTNLSKI | YGPVFTLYFG | LERMVVLHGY | EVVKEALIDL | GEEFSGRGHF |

150:

PLAERANRGF | GIVFSNGKRW | KEIRRFSLMT | LRNFGMGKRS | IEDRVQEEAR |

200:

CLVEELRKTK | ASPCDPTFIL | GCAPCNVICS | IIFQKRFDYK | DQQFLNLMEK |

250:

LNENIRIVST | PWIQICNNFP | TIIDYFPGTH | NKLLKNLAFM | ESDILEKVKE |

300:

HQESMDINNP | RDFIDCFLIK | MEKEKQNQQS | EFTIENLVIT | AADLLGAGTE |

350:

TTSTTLRYAL | LLLLKHPEVT | AKVQEEIERV | VGRNRSPCMQ | DRGHMPYTDA |

400:

VVHEVQRYID | LIPTSLPHAV | TCDVKFRNYL | IPKGTTILTS | LTSVLHDNKE |

450:

FPNPEMFDPR | HFLDEGGNFK | KSNYFMPFSA | GKRICVGEGL | ARMELFLFLT |

490:

FILQNFNLKS | LIDPKDLDTT | PVVNGFASVP | PFYQLCFIPV |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

KEGG:

STRING:

9606.ENSP00000360372

String:

Pfam:

SMR:

UniGene:

Uniprot:

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ELISA Kit for Human Cytochrome P450 2C19

Cat.:

E5894h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Cytochrome P450 2C19

Cat.:

U5894h

Price:

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Manual:

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MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Cytochrome P450 2C19

Cat.:

P5894Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Cytochrome P450 2C19

Protein for Human Cytochrome P450 2C19

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily."
Romkes M. , Faletto M.B. , Blaisdell J.A. , Raucy J.L. , Goldstein J.A.
Biochemistry30:3247-3255(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CYP2C19*1A)
tissue: Liver.
2.

Romkes M. , Faletto M.B. , Blaisdell J.A. , Raucy J.L. , Goldstein J.A.
Biochemistry32:1390-1390(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION
3.

NIEHS SNPs program
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-19; ASP-92; ALA-122; HIS-144; ILE-331 AND CYS-410
4.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"Gene structure, upstream region and allelic variants of cyp2c19, the s-mephenytoin hydroxylase."
de Morais S.M.F. , Blaisdell J.A.
Submitted (2001-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-160 AND 274-490;VARIANT ILE-331
6.

"Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation."
Wrighton S.A. , Stevens J.C. , Becker G.W. , VandenBranden M.
Arch. Biochem. Biophys.306:240-245(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-16
tissue: Liver.
7.

"Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes."
Miyazawa M. , Shindo M. , Shimada T.
Drug Metab. Dispos.30:602-607(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
8.

"Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19."
Reynald R.L. , Sansen S. , Stout C.D. , Johnson E.F.
J. Biol. Chem.287:44581-44591(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.87 ANGSTROMS) OF 23-489 IN COMPLEX WITH HEME AND SYNTHETIC INHIBITOR;COFACTOR
9.

"The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans."
de Morais S.M.F. , Wilkinson G.R. , Blaisdell J. , Nakamura K. , Meyer U.A. , Goldstein J.A.
J. Biol. Chem.269:15419-15422(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN POOR DRUG METABOLISM;IDENTIFICATION OF ALLELE CYP2C19*2A
10.

"Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese."
De Morais S.M.F. , Wilkinson G.R. , Blaisdell J. , Meyer U.A. , Nakamura K. , Goldstein J.A.
Mol. Pharmacol.46:594-598(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN POOR DRUG METABOLISM;IDENTIFICATION OF ALLELE CYP2C19*3A
11.

"Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele."
Xiao Z.S. , Goldstein J.A. , Xie H.G. , Blaisdell J. , Wang W. , Jiang C.H. , Yan F.X. , He N. , Huang S.L. , Xu Z.H. , Zhou H.H.
J. Pharmacol. Exp. Ther.281:604-609(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-433
12.

"Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin."
Ibeanu G.C. , Goldstein J.A. , Meyer U.A. , Benhamou S. , Bouchardy C. , Dayer P. , Ghanayem B.I. , Blaisdell J.
J. Pharmacol. Exp. Ther.286:1490-1495(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-92 AND GLN-132
13.

"An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians."
Ibeanu G.C. , Blaisdell J. , Ghanayem B.I. , Beyeler C. , Benhamou S. , Bouchardy C. , Wilkinson G.R. , Dayer P. , Daly A.K. , Goldstein J.A.
Pharmacogenetics8:129-135(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-433
14.

"A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin."
Ibeanu G.C. , Blaisdell J. , Ferguson R.J. , Ghanayem B.I. , Brosen K. , Benhamou S. , Bouchardy C. , Wilkinson G.R. , Dayer P. , Goldstein J.A.
J. Pharmacol. Exp. Ther.290:635-640(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-120
15.

"Identification and functional characterization of new potentially defective alleles of human CYP2C19."
Blaisdell J. , Mohrenweiser H. , Jackson J. , Ferguson S. , Coulter S. , Chanas B. , Xi T. , Ghanayem B. , Goldstein J.A.
Pharmacogenetics12:703-711(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-17; LEU-19; HIS-144; HIS-150; LEU-227 AND CYS-410
16.

"A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation."
Morita J. , Kobayashi K. , Wanibuchi A. , Kimura M. , Irie S. , Ishizaki T. , Chiba K.
Drug Metab. Pharmacokinet.19:236-238(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYS-442
17.

"Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
Solus J.F. , Arietta B.J. , Harris J.R. , Sexton D.P. , Steward J.Q. , McMunn C. , Ihrie P. , Mehall J.M. , Edwards T.L. , Dawson E.P.
Pharmacogenomics5:895-931(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-74; HIS-144; LEU-168 AND ILE-331
18.

"Genetic variations and haplotypes of CYP2C19 in a Japanese population."
Fukushima-Uesaka H. , Saito Y. , Maekawa K. , Ozawa S. , Hasegawa R. , Kajio H. , Kuzuya N. , Yasuda K. , Kawamoto M. , Kamatani N. , Suzuki K. , Yanagawa T. , Tohkin M. , Sawada J.
Drug Metab. Pharmacokinet.20:300-307(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLY-51; PRO-161; HIS-329 AND ILE-331

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