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Index > Protein center > CYP2C19(Gene name) > Human
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  • CYP2C19 (Gene name),
  • Cytochrome P450 2C19 (Protein name ),  CP2CJ_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CYP2C19;
    Protein name:
    Cytochrome P450 2C19;
    Alternative:
    1.14.13.48;(S)-limonene 6-monooxygenase);1.14.13.80;(R)-limonene 6-monooxygenase);CYPIIC17;1.14.13.49;(S)-limonene 7-monooxygenase);Cytochrome P450-11A;CYPIIC19;Mephenytoin 4-hydroxylase;Cytochrome P450-254C;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
    Subcellular Location:
    Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    490
    Sequence:
    50:
    MDPFVVLVLC | LSCLLLLSIW | RQSSGRGKLP | PGPTPLPVIG | NILQIDIKDV | 
    100:
    SKSLTNLSKI | YGPVFTLYFG | LERMVVLHGY | EVVKEALIDL | GEEFSGRGHF | 
    150:
    PLAERANRGF | GIVFSNGKRW | KEIRRFSLMT | LRNFGMGKRS | IEDRVQEEAR | 
    200:
    CLVEELRKTK | ASPCDPTFIL | GCAPCNVICS | IIFQKRFDYK | DQQFLNLMEK | 
    250:
    LNENIRIVST | PWIQICNNFP | TIIDYFPGTH | NKLLKNLAFM | ESDILEKVKE | 
    300:
    HQESMDINNP | RDFIDCFLIK | MEKEKQNQQS | EFTIENLVIT | AADLLGAGTE | 
    350:
    TTSTTLRYAL | LLLLKHPEVT | AKVQEEIERV | VGRNRSPCMQ | DRGHMPYTDA | 
    400:
    VVHEVQRYID | LIPTSLPHAV | TCDVKFRNYL | IPKGTTILTS | LTSVLHDNKE | 
    450:
    FPNPEMFDPR | HFLDEGGNFK | KSNYFMPFSA | GKRICVGEGL | ARMELFLFLT | 
    490:
    FILQNFNLKS | LIDPKDLDTT | PVVNGFASVP | PFYQLCFIPV | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    KEGG:
    String:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cytochrome P450 2C19
    Cat.:
    E5894h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Cytochrome P450 2C19
    Cat.:
    U5894h
    Price:
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    MSDS:
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    Packing:
    96T
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    Polyclonal Antibody for Human Cytochrome P450 2C19
    Cat.:
    P5894Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cytochrome P450 2C19
    Protein for Human Cytochrome P450 2C19

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily."
      Romkes M. , Faletto M.B. , Blaisdell J.A. , Raucy J.L. , Goldstein J.A.
      Biochemistry30:3247-3255(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CYP2C19*1A)
      tissue: Liver.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION
    3. 3.
      NIEHS SNPs program
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-19; ASP-92; ALA-122; HIS-144; ILE-331 AND CYS-410
    4. 4.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Gene structure, upstream region and allelic variants of cyp2c19, the s-mephenytoin hydroxylase."
      de Morais S.M.F. , Blaisdell J.A.
      Submitted (2001-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-160 AND 274-490;VARIANT ILE-331
    6. 6.
      "Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation."
      Wrighton S.A. , Stevens J.C. , Becker G.W. , VandenBranden M.
      Arch. Biochem. Biophys.306:240-245(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-16
      tissue: Liver.
    7. 7.
      "Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes."
      Miyazawa M. , Shindo M. , Shimada T.
      Drug Metab. Dispos.30:602-607(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    8. 8.
      "Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19."
      Reynald R.L. , Sansen S. , Stout C.D. , Johnson E.F.
      J. Biol. Chem.287:44581-44591(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.87 ANGSTROMS) OF 23-489 IN COMPLEX WITH HEME AND SYNTHETIC INHIBITOR;COFACTOR
    9. 9.
      "The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans."
      de Morais S.M.F. , Wilkinson G.R. , Blaisdell J. , Nakamura K. , Meyer U.A. , Goldstein J.A.
      J. Biol. Chem.269:15419-15422(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN POOR DRUG METABOLISM;IDENTIFICATION OF ALLELE CYP2C19*2A
    10. 10.
      "Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese."
      De Morais S.M.F. , Wilkinson G.R. , Blaisdell J. , Meyer U.A. , Nakamura K. , Goldstein J.A.
      Mol. Pharmacol.46:594-598(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN POOR DRUG METABOLISM;IDENTIFICATION OF ALLELE CYP2C19*3A
    11. 11.
      "Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele."
      Xiao Z.S. , Goldstein J.A. , Xie H.G. , Blaisdell J. , Wang W. , Jiang C.H. , Yan F.X. , He N. , Huang S.L. , Xu Z.H. , Zhou H.H.
      J. Pharmacol. Exp. Ther.281:604-609(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-433
    12. 12.
      "Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin."
      Ibeanu G.C. , Goldstein J.A. , Meyer U.A. , Benhamou S. , Bouchardy C. , Dayer P. , Ghanayem B.I. , Blaisdell J.
      J. Pharmacol. Exp. Ther.286:1490-1495(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-92 AND GLN-132
    13. 13.
      "An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians."
      Ibeanu G.C. , Blaisdell J. , Ghanayem B.I. , Beyeler C. , Benhamou S. , Bouchardy C. , Wilkinson G.R. , Dayer P. , Daly A.K. , Goldstein J.A.
      Pharmacogenetics8:129-135(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-433
    14. 14.
      "A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin."
      Ibeanu G.C. , Blaisdell J. , Ferguson R.J. , Ghanayem B.I. , Brosen K. , Benhamou S. , Bouchardy C. , Wilkinson G.R. , Dayer P. , Goldstein J.A.
      J. Pharmacol. Exp. Ther.290:635-640(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-120
    15. 15.
      "Identification and functional characterization of new potentially defective alleles of human CYP2C19."
      Blaisdell J. , Mohrenweiser H. , Jackson J. , Ferguson S. , Coulter S. , Chanas B. , Xi T. , Ghanayem B. , Goldstein J.A.
      Pharmacogenetics12:703-711(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-17; LEU-19; HIS-144; HIS-150; LEU-227 AND CYS-410
    16. 16.
      "A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation."
      Morita J. , Kobayashi K. , Wanibuchi A. , Kimura M. , Irie S. , Ishizaki T. , Chiba K.
      Drug Metab. Pharmacokinet.19:236-238(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYS-442
    17. 17.
      "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
      Solus J.F. , Arietta B.J. , Harris J.R. , Sexton D.P. , Steward J.Q. , McMunn C. , Ihrie P. , Mehall J.M. , Edwards T.L. , Dawson E.P.
      Pharmacogenomics5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-74; HIS-144; LEU-168 AND ILE-331
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLY-51; PRO-161; HIS-329 AND ILE-331
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