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Index > Protein center > CYP3A4(Gene name) > Human
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  • CYP3A4 (Gene name),
  • Cytochrome P450 3A4 (Protein name ),  CP3A4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CYP3A4(CYP3A3);
    Protein name:
    Cytochrome P450 3A4;
    Alternative:
    Quinine 3-monooxygenase;1.14.13.97;1.14.13.32;Taurochenodeoxycholate 6-alpha-hydroxylase(Albendazole sulfoxidase);1.14.13.67;1.14.13.157;Taurochenodeoxycholate 6-alpha-hydroxylase(Albendazole monooxygenase);CYPIIIA4;CYPIIIA3;Cytochrome P450 HLp;Cytochrome P450 3A3;Cytochrome P450-PCN1;Cytochrome P450 NF-25;Nifedipine oxidase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass membrane protein Microsome membrane Single-pass membrane protein
    Protein Attributes:
    Sequence length:
    503
    Sequence:
    50:
    MALIPDLAME | TWLLLAVSLV | LLYLYGTHSH | GLFKKLGIPG | PTPLPFLGNI | 
    100:
    LSYHKGFCMF | DMECHKKYGK | VWGFYDGQQP | VLAITDPDMI | KTVLVKECYS | 
    150:
    VFTNRRPFGP | VGFMKSAISI | AEDEEWKRLR | SLLSPTFTSG | KLKEMVPIIA | 
    200:
    QYGDVLVRNL | RREAETGKPV | TLKDVFGAYS | MDVITSTSFG | VNIDSLNNPQ | 
    250:
    DPFVENTKKL | LRFDFLDPFF | LSITVFPFLI | PILEVLNICV | FPREVTNFLR | 
    300:
    KSVKRMKESR | LEDTQKHRVD | FLQLMIDSQN | SKETESHKAL | SDLELVAQSI | 
    350:
    IFIFAGYETT | SSVLSFIMYE | LATHPDVQQK | LQEEIDAVLP | NKAPPTYDTV | 
    400:
    LQMEYLDMVV | NETLRLFPIA | MRLERVCKKD | VEINGMFIPK | GVVVMIPSYA | 
    450:
    LHRDPKYWTE | PEKFLPERFS | KKNKDNIDPY | IYTPFGSGPR | NCIGMRFALM | 
    500:
    NMKLALIRVL | QNFSFKPCKE | TQIPLKLSLG | GLLQPEKPVV | LKVESRDGTV | 
    503:
    SGA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    UniGene:
    SMR:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cytochrome P450 3A4
    Cat.:
    E0217h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Cytochrome P450 3A4
    Cat.:
    U0217h
    Price:
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    MSDS:
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    Packing:
    96T
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    Polyclonal Antibody for Human Cytochrome P450 3A4
    Cat.:
    P0217Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cytochrome P450 3A4
    Protein for Human Cytochrome P450 3A4

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver."
      Molowa D.T. , Schuetz E.G. , Wrighton S.A. , Watkins P.B. , Kremers P. , Mendez-Picon G. , Parker G.A. , Guzelian P.S.
      Proc. Natl. Acad. Sci. U.S.A.83:5311-5315(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ALA-252
      tissue: Liver.
    2. 2.
      "Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase."
      Gonzalez F.J. , Schmid B.J. , Umeno M. , McBride O.W. , Hardwick J.P. , Meyer U.A. , Gelboin H.V. , Idle J.R.
      DNA7:79-86(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase."
      Beaune P.H. , Umbenhauer D.R. , Bork R.W. , Lloyd R.S. , Guengerich F.P.
      Proc. Natl. Acad. Sci. U.S.A.83:8064-8068(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-431
    4. 4.
      "The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter."
      Spurr N.K. , Gough A.C. , Stevenson K. , Wolf C.R.
      Hum. Genet.81:171-174(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity."
      Bork R.W. , Muto T. , Beaune P.H. , Srivastava P.K. , Lloyd R.S. , Guengerich F.P.
      J. Biol. Chem.264:910-919(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-431
      tissue: Liver.
    6. 6.
      "Establishment of transgenic cell line CHL-3A4 and its metabolic activation."
      Chen Q. , Wu J. , Yu Y.
      Zhonghua Yu Fang Yi Xue Za Zhi32:281-284(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    7. 7.
      "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene."
      Gellner K. , Eiselt R. , Hustert E. , Arnold H. , Koch I. , Haberl M. , Deglmann C.J. , Burk O. , Buntefuss D. , Escher S. , Bishop C. , Koebe H.-G. , Brinkmann U. , Klenk H.-P. , Kleine K. , Meyer U.A. , Wojnowski L.
      Pharmacogenetics11:111-121(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-118 AND ARG-218
    9. 9.
      "Sequence of a new human cytochrome P450-3A4 cDNA."
      Zhuge J. , Qian Y. , Xie H. , Yu Y.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    10. 10.
      "Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization."
      Komori M. , Hashizume T. , Ohi H. , Miura T. , Kitada M. , Nagashima K. , Kamataki T.
      J. Biochem.104:912-916(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-25;CLEAVAGE OF INITIATOR METHIONINE
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21;CLEAVAGE OF INITIATOR METHIONINE
      tissue: Liver.
    12. 12.
      "Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine."
      Aoyama T. , Yamano S. , Waxman D.J. , Lapenson D.P. , Meyer U.A. , Fischer V. , Tyndale R. , Inaba T. , Kalow W. , Gelboin H.V. , Gonzalez F.J.
      J. Biol. Chem.264:10388-10395(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    13. 13.
      "Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians."
      Shimada T. , Yamazaki H. , Mimura M. , Inui Y. , Guengerich F.P.
      J. Pharmacol. Exp. Ther.270:414-423(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    15. 15.
      "Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine."
      Zhang H. , Coville P.F. , Walker R.J. , Miners J.O. , Birkett D.J. , Wanwimolruk S.
      Br. J. Clin. Pharmacol.43:245-252(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    16. 16.
      "Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways."
      Zhao X.J. , Kawashiro T. , Ishizaki T.
      Drug Metab. Dispos.26:188-191(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    17. 17.
      "Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes."
      Miyazawa M. , Shindo M. , Shimada T.
      Drug Metab. Dispos.29:200-205(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION AS 1,8-CINEOLE 2-EXO-MONOOXYGENASE
    18. 18.
      "Intergenic mRNA molecules resulting from trans-splicing."
      Finta C. , Zaphiropoulos P.G.
      J. Biol. Chem.277:5882-5890(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TRANS-SPLICING
    19. 19.
      "ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier."
      Dauchy S. , Dutheil F. , Weaver R.J. , Chassoux F. , Daumas-Duport C. , Couraud P.O. , Scherrmann J.M. , De Waziers I. , Decleves X.
      J. Neurochem.107:1518-1528(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    20. 20.
      "Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite."
      Agarwal V. , Kommaddi R.P. , Valli K. , Ryder D. , Hyde T.M. , Kleinman J.E. , Strobel H.W. , Ravindranath V.
      PLoS ONE3:E2337-E2337(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    21. 21.
      "CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases."
      Pabarcus M.K. , Hoe N. , Sadeghi S. , Patterson C. , Wiertz E. , Correia M.A.
      Arch. Biochem. Biophys.483:66-74(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    22. 22.
      "Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function."
      Dutheil F. , Dauchy S. , Diry M. , Sazdovitch V. , Cloarec O. , Mellottee L. , Bieche I. , Ingelman-Sundberg M. , Flinois J.P. , de Waziers I. , Beaune P. , Decleves X. , Duyckaerts C. , Loriot M.A.
      Drug Metab. Dispos.37:1528-1538(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    23. 23.
      "The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution."
      Yano J.K. , Wester M.R. , Schoch G.A. , Griffin K.J. , Stout C.D. , Johnson E.F.
      J. Biol. Chem.279:38091-38094(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 24-503
    24. 24.
      "Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone."
      Williams P.A. , Cosme J. , Vinkovic D.M. , Ward A. , Angove H.C. , Day P.J. , Vonrhein C. , Tickle I.J. , Jhoti H.
      Science305:683-686(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 25-503
    25. 25.
      "CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity."
      Sata F. , Sapone A. , Elizondo G. , Stocker P. , Miller V.P. , Zheng W. , Raunio H. , Crespi C.L. , Gonzalez F.J.
      Clin. Pharmacol. Ther.67:48-56(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-222 AND THR-445
    26. 26.
      "Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos."
      Dai D. , Tang J. , Rose R. , Hodgson E. , Bienstock R.J. , Mohrenweiser H.W. , Goldstein J.A.
      J. Pharmacol. Exp. Ther.299:825-831(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLN-162; SER-189; PRO-293; THR-445 AND SER-467;CHARACTERIZATION OF THE VARIANTS
    27. 27.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-56; GLN-130; ILE-170; HIS-174; MET-363; PHE-373 AND LEU-416
    28. 28.
      "Common allelic variants of cytochrome P4503A4 and their prevalence in different populations."
      Lamba J.K. , Lin Y.S. , Thummel K. , Daly A. , Watkins P.B. , Strom S. , Zhang J. , Schuetz E.G.
      Pharmacogenetics12:121-132(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-15; GLN-162; HIS-174; SER-185 AND PHE-373
    29. 29.
      "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
      Solus J.F. , Arietta B.J. , Harris J.R. , Sexton D.P. , Steward J.Q. , McMunn C. , Ihrie P. , Mehall J.M. , Edwards T.L. , Dawson E.P.
      Pharmacogenomics5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-174; SER-185 AND PRO-293
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