Gene name:
CYP8B1 (CYP12) ;
Protein name:
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase ;
Alternative:
CYPVIIIB1 ;7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase ;Sterol 12-alpha-hydroxylase ;Cytochrome P450 8B1 ;
Organism:
Rabbit (Oryctolagus cuniculus).
General Annotation
Function:
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
Subcellular Location:
Endoplasmic reticulum membrane
Single-pass membrane protein
Microsome membrane
Single-pass membrane protein
Protein Attributes:
50:
MVLWGLLGAL | LMVMVGWLCL | PGLLRQRRPQ | EPPLDKGSIP | WLGHAMTFRK |
100:
NMLEFLKHMR | SKHGDVFTVQ | LGGQYFTFVM | DPVSFGPILK | DGQRKLDFVE |
150:
YAKGLVLKVF | GYQSIEGDHR | MIHLASTKHL | MGHGLEELNK | AMLDSLSLVM |
200:
LGPEGRSPDA | SRWHEDGLFH | FCYGVMFKAG | YLSLFGHTSD | KRQDLLQAEE |
250:
IFIKFRRFDL | LFPRFVYSLL | GPREWREVGR | LQQLFHELLS | VKHNPEKDGM |
300:
SNWIGHMLQY | LSEQGVAPAM | QDKFNFMMLW | ASQGNTGPAS | FWALIYLLKH |
350:
PEAMRAVKEE | ATRVLGEPRL | EAKQSFTVQL | SALQHIPVLD | SVMEETLRLG |
400:
AAPTLYRVVQ | KDILLKMASG | QECLLRQGDI | VTLFPYLSVH | MDPDIHPEPT |
450:
TFKYDRFLNP | NGSRKVDFYK | AGQKIHHYTM | PWGSGVSICP | GRFFALSEMK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rabbit
Pig
Mouse
ELISA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
ELISA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
ELISA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
ELISA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
CLIA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
CLIA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
CLIA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
CLIA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Polyclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Polyclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Polyclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Polyclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Monoclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Monoclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Monoclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Monoclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Protein for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Protein for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Protein for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Protein for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 109-120; 129-140; 215-223; 231-242; 324-343; 367-376; 478-491 AND 496-500
strain :
New Zealand white .
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-16
tissue :
Liver .