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Index > Protein center > CYP8B1(Gene name) > Rabbit
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  • CYP8B1 (Gene name),
  • 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (Protein name ),  CP8B1_RABIT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Gene name:
    CYP8B1(CYP12);
    Protein name:
    7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase;
    Alternative:
    CYPVIIIB1;7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase;Sterol 12-alpha-hydroxylase;Cytochrome P450 8B1;
    Organism:
    Rabbit (Oryctolagus cuniculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass membrane protein Microsome membrane Single-pass membrane protein
    Protein Attributes:
    Sequence length:
    500
    Sequence:
    50:
    MVLWGLLGAL | LMVMVGWLCL | PGLLRQRRPQ | EPPLDKGSIP | WLGHAMTFRK | 
    100:
    NMLEFLKHMR | SKHGDVFTVQ | LGGQYFTFVM | DPVSFGPILK | DGQRKLDFVE | 
    150:
    YAKGLVLKVF | GYQSIEGDHR | MIHLASTKHL | MGHGLEELNK | AMLDSLSLVM | 
    200:
    LGPEGRSPDA | SRWHEDGLFH | FCYGVMFKAG | YLSLFGHTSD | KRQDLLQAEE | 
    250:
    IFIKFRRFDL | LFPRFVYSLL | GPREWREVGR | LQQLFHELLS | VKHNPEKDGM | 
    300:
    SNWIGHMLQY | LSEQGVAPAM | QDKFNFMMLW | ASQGNTGPAS | FWALIYLLKH | 
    350:
    PEAMRAVKEE | ATRVLGEPRL | EAKQSFTVQL | SALQHIPVLD | SVMEETLRLG | 
    400:
    AAPTLYRVVQ | KDILLKMASG | QECLLRQGDI | VTLFPYLSVH | MDPDIHPEPT | 
    450:
    TFKYDRFLNP | NGSRKVDFYK | AGQKIHHYTM | PWGSGVSICP | GRFFALSEMK | 
    500:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Cat.:
    E10332h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    MSDS:
    Please sign in first.
    ELISA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Cat.:
    E10332p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Cat.:
    E10332m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Cat.:
    U10332m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    MSDS:
    Please sign in first.
    CLIA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Cat.:
    U10332h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Cat.:
    U10332p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Polyclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Cat.:
    P10332Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Polyclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Cat.:
    P10332Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Monoclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Monoclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Monoclonal Antibody for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Protein for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Protein for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Protein for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Protein for Rabbit 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and expression of rabbit sterol 12alpha-hydroxylase."
      Eggertsen G. , Olin M. , Andersson U. , Ishida H. , Kubota S. , Hellman U. , Okuda K. , Bjoerkhem I.
      J. Biol. Chem.271:32269-32275(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 109-120; 129-140; 215-223; 231-242; 324-343; 367-376; 478-491 AND 496-500
      strain: New Zealand white.
      tissue: Liver.
    2. 2.
      "Purification and characterization of 7 alpha-hydroxy-4-cholesten-3-one 12 alpha-hydroxylase."
      Ishida H. , Noshiro M. , Okuda K. , Coon M.J.
      J. Biol. Chem.267:21319-21323(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-16
      tissue: Liver.
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