CPSF3 ELISA Kit for Bovine(Bos taurus) | EIAab.comCPSF3 ELISA Kit for Bovine(Bos taurus)

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CPSF3 (Gene name),

Cleavage and polyadenylation specificity factor subunit 3 (Protein name ), CPSF3_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CPSF3(CPSF73);

Protein name:

Cleavage and polyadenylation specificity factor subunit 3;

Alternative:

mRNA 3'-end-processing endonuclease CPSF-73;Cleavage and polyadenylation specificity factor 73 kDa subunit(CPSF 73 kDa subunit);

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with CPSF2, CSTF2 and SYMPK. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3'UTR of pre-mRNAs.

Function:

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

684

Sequence:

50:

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150:

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250:

300:

350:

400:

450:

500:

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600:

650:

684:

RTVECEEGSE | DDESLREMVE | LAAQRLYEAL | TPVH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Bt.5045

SMR:

P79101

Pfam:

PF10996

String:

P79101

KEGG:

bta:281712

Uniprot:

P79101

FOR

ELISA Kit for Bovine Cleavage and polyadenylation specificity factor subunit 3

CLIA Kit for Bovine Cleavage and polyadenylation specificity factor subunit 3

Polyclonal Antibody for Bovine Cleavage and polyadenylation specificity factor subunit 3

Monoclonal Antibody for Bovine Cleavage and polyadenylation specificity factor subunit 3

Protein for Bovine Cleavage and polyadenylation specificity factor subunit 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I."
Jenny A. , Minvielle-Sebastia L. , Preker P.J. , Keller W.
Science274:1514-1517(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Hereford.
tissue: Uterus.

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