ORAI1 ELISA Kit for Human(Homo sapiens) | EIAab.comORAI1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ORAI1(Gene name) > Human

ORAI1 (Gene name),

Calcium release-activated calcium channel protein 1 (Protein name ), CRCM1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ORAI1(CRACM1;TMEM142A);

Protein name:

Calcium release-activated calcium channel protein 1;

Alternative:

Transmembrane protein 142A;Protein orai-1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with STIM1 and STIM2. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations.

Function:

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

301

Sequence:

50:

100:

150:

200:

250:

300:

301:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:84876

UniGene:

Hs.55148

STRING:

9606.ENSP00000328216

SMR:

Q96D31

String:

Q96D31

Pfam:

PF07856

MIM:

610277

Uniprot:

Q96D31

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ELISA Kit for Human Calcium release-activated calcium channel protein 1

Cat.:

E15347r

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96T

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ELISA Kit for Human Calcium release-activated calcium channel protein 1

Cat.:

E15347h

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96T

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ELISA Kit for Human Calcium release-activated calcium channel protein 1

Cat.:

E15347m

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96T

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ELISA Kit for Human Calcium release-activated calcium channel protein 1

Cat.:

E15347c

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96T

CLIA Kit for Human Calcium release-activated calcium channel protein 1

Cat.:

U15347h

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Packing:

96T

CLIA Kit for Human Calcium release-activated calcium channel protein 1

Cat.:

U15347r

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MSDS:

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Packing:

96T

CLIA Kit for Human Calcium release-activated calcium channel protein 1

Cat.:

U15347m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Calcium release-activated calcium channel protein 1

Cat.:

U15347c

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Packing:

96T

Polyclonal Antibody for Human Calcium release-activated calcium channel protein 1

Cat.:

P15347Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Calcium release-activated calcium channel protein 1

Cat.:

P15347Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Calcium release-activated calcium channel protein 1

Cat.:

P15347Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Calcium release-activated calcium channel protein 1

Protein for Human Calcium release-activated calcium channel protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA);VARIANT GLY-218
tissue: Bone marrow.
tissue: Ovary.
tissue: Prostate.
tissue: Uterus.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-301 (ISOFORM ALPHA);VARIANT GLY-218
tissue: Mammary gland.
3.

"A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients."
Feske S. , Prakriya M. , Rao A. , Lewis R.S.
J. Exp. Med.202:651-662(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN IMD9
4.

"Orai1 and STIM reconstitute store-operated calcium channel function."
Soboloff J. , Spassova M.A. , Tang X.D. , Hewavitharana T. , Xu W. , Gill D.L.
J. Biol. Chem.281:20661-20665(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1."
Mercer J.C. , Dehaven W.I. , Smyth J.T. , Wedel B. , Boyles R.R. , Bird G.S. , Putney J.W. Jr.
J. Biol. Chem.281:24979-24990(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Amplification of CRAC current by STIM1 and CRACM1 (Orai1)."
Peinelt C. , Vig M. , Koomoa D.L. , Beck A. , Nadler M.J.S. , Koblan-Huberson M. , Lis A. , Fleig A. , Penner R. , Kinet J.-P.
Nat. Cell Biol.8:771-773(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry."
Vig M. , Peinelt C. , Beck A. , Koomoa D.L. , Rabah D. , Koblan-Huberson M. , Kraft S. , Turner H. , Fleig A. , Penner R. , Kinet J.-P.
Science312:1220-1223(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
8.

"STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation."
Parvez S. , Beck A. , Peinelt C. , Soboloff J. , Lis A. , Monteilh-Zoller M. , Gill D.L. , Fleig A. , Penner R.
FASEB J.22:752-761(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STIM1 AND STIM2
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-295 AND SER-298;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1."
Park C.Y. , Hoover P.J. , Mullins F.M. , Bachhawat P. , Covington E.D. , Raunser S. , Walz T. , Garcia K.C. , Dolmetsch R.E. , Lewis R.S.
Cell136:876-890(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH STIM1;SUBCELLULAR LOCATION;TOPOLOGY;SUBUNIT;GLYCOSYLATION
11.

"POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."
Krapivinsky G. , Krapivinsky L. , Stotz S.C. , Manasian Y. , Clapham D.E.
Proc. Natl. Acad. Sci. U.S.A.108:19234-19239(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC35G1
12.

"Alternative translation initiation gives rise to two isoforms of orai1 with distinct plasma membrane mobilities."
Fukushima M. , Tomita T. , Janoshazi A. , Putney J.W.
J. Cell Sci.125:4354-4361(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE INITIATION;SUBCELLULAR LOCATION
13.

"Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)."
Srikanth S. , Jew M. , Kim K.D. , Yee M.K. , Abramson J. , Gwack Y.
Proc. Natl. Acad. Sci. U.S.A.109:8682-8687(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ASPH
14.

"A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."
Srikanth S. , Jung H.J. , Kim K.D. , Souda P. , Whitelegge J. , Gwack Y.
Nat. Cell Biol.12:436-446(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRACR2A;MUTAGENESIS OF 85-LYS--LYS-87
15.

"Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis."
Nesin V. , Wiley G. , Kousi M. , Ong E.C. , Lehmann T. , Nicholl D.J. , Suri M. , Shahrizaila N. , Katsanis N. , Gaffney P.M. , Wierenga K.J. , Tsiokas L.
Proc. Natl. Acad. Sci. U.S.A.111:4197-4202(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN TAM2;VARIANT TAM2 LEU-245;CHARACTERIZATION OF VARIANT TAM2 LEU-245
16.

"Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode."
Liu Y. , Zheng X. , Mueller G.A. , Sobhany M. , DeRose E.F. , Zhang Y. , London R.E. , Birnbaumer L.
J. Biol. Chem.287:43030-43041(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 69-88 IN COMPLEX WITH CALM;INTERACTION WITH CALM
17.

"STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry."
Stathopulos P.B. , Schindl R. , Fahrner M. , Zheng L. , Gasmi-Seabrook G.M. , Muik M. , Romanin C. , Ikura M.
Nat. Commun.4:2963-2963(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 272-292 IN COMPLEX WITH STIM1;INTERACTION WITH STIM1;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-281; ASP-284; LEU-286; ASP-287; ARG-289 AND ASP-291
18.

"A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."
Feske S. , Gwack Y. , Prakriya M. , Srikanth S. , Puppel S.-H. , Tanasa B. , Hogan P.G. , Lewis R.S. , Daly M. , Rao A.
Nature441:179-185(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IMD9 TRP-91;SUBCELLULAR LOCATION;FUNCTION

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