CREB1 ELISA Kit for Human(Homo sapiens) | EIAab.comCREB1 ELISA Kit for Human(Homo sapiens)

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CREB1 (Gene name),

Cyclic AMP-responsive element-binding protein 1 (Protein name ), CREB1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CREB1;

Protein name:

Cyclic AMP-responsive element-binding protein 1(CREB-1;cAMP-responsive element-binding protein 1);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP (By similarity). Interacts (phosporylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2.

Function:

This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

341

Sequence:

50:

100:

150:

200:

250:

300:

341:

RRKKKEYVKC | LENRVAVLEN | QNKTLIEELK | ALKDLYCHKS | D

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P16220

UniGene:

Hs.516646

Pfam:

PF00170

KEGG:

hsa:1385

String:

P16220

MIM:

123810

STRING:

9606.ENSP00000387699

Uniprot:

P16220

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ELISA Kit for Human CREB-1

Cat.:

E1318h

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96T

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ELISA Kit for Human CREB-1

Cat.:

E1318r

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96T

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ELISA Kit for Human CREB-1

Cat.:

E1318m

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96T

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ELISA Kit for Human CREB-1

Cat.:

E1318b

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96T

CLIA Kit for Human CREB-1

Cat.:

U1318m

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96T

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CLIA Kit for Human CREB-1

Cat.:

U1318h

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human CREB-1

Cat.:

U1318r

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Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human CREB-1

Cat.:

U1318b

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96T

Polyclonal Antibody for Human CREB-1

Cat.:

P1318Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human CREB-1

Cat.:

P1318Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human CREB-1

Cat.:

P1318Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human CREB-1

Protein for Human CREB-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Two distinct forms of active transcription factor CREB (cAMP response element binding protein)."
Berkowitz L.A. , Gilman M.Z.
Proc. Natl. Acad. Sci. U.S.A.87:5258-5262(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-A)
2.

"Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain."
Yoshimura T. , Fujisawa J. , Yoshida M.
EMBO J.9:2537-2542(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-A)
3.

"Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing."
Waeber G. , Meyer T.E. , Hoeffler J.P. , Habener J.F.
Trans. Assoc. Am. Physicians103:28-37(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-A)
4.

"Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA."
Hoeffler J.P. , Meyer T.E. , Yun Y. , Jameson J.L. , Habener J.F.
Science242:1430-1433(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-B)
5.

"Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells."
Short M.L. , Manohar C.F. , Furtado M.R. , Ghadge G.D. , Wolinsky S.M. , Thimmapaya B. , Jungmann R.A.
Nucleic Acids Res.19:4290-4290(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-B)
6.

"Cloning and expression of a novel CREB mRNA splice variant in human testis."
Huang X. , Zhang J. , Lu L. , Yin L. , Xu M. , Wang Y. , Zhou Z. , Sha J.
Reproduction128:775-782(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue: Testis.
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CREB-A)
tissue: Eye.
8.

"The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription."
Meyer T.E. , Waeber G. , Lin J. , Beckmann W. , Habener J.F.
Endocrinology132:770-780(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8
9.

"HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions."
Maguire H.F. , Hoeffler J.P. , Siddiqui A.
Science252:842-844(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HBV PROTEIN X
10.

"Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction."
Zhao L.J. , Giam C.-Z.
Proc. Natl. Acad. Sci. U.S.A.89:7070-7074(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HTLV-1 TAX-1
11.

"Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression."
Matthews R.P. , Guthrie C.R. , Wailes L.M. , Zhao X. , Means A.R. , McKnight G.S.
Mol. Cell. Biol.14:6107-6116(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-133;MUTAGENESIS OF SER-133
12.

"Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133."
Lee H.-J.J. , Mignacca R.C. , Sakamoto K.M.
J. Biol. Chem.270:15979-15983(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-133
13.

"CREB is a regulatory target for the protein kinase Akt/PKB."
Du K. , Montminy M.
J. Biol. Chem.273:32377-32379(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-133
14.

"Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene."
De Cesare D. , Jacquot S. , Hanauer A. , Sassone-Corsi P.
Proc. Natl. Acad. Sci. U.S.A.95:12202-12207(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-133
15.

"TORCs: transducers of regulated CREB activity."
Conkright M.D. , Canettieri G. , Screaton R. , Guzman E. , Miraglia L. , Hogenesch J.B. , Montminy M.
Mol. Cell12:413-423(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRTC1
16.

"Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia."
Comerford K.M. , Leonard M.O. , Karhausen J. , Carey R. , Colgan S.P. , Taylor C.T.
Proc. Natl. Acad. Sci. U.S.A.100:986-991(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-285 AND LYS-304;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-155; LYS-285 AND LYS-304
17.

"Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells."
Iourgenko V. , Zhang W. , Mickanin C. , Daly I. , Jiang C. , Hexham J.M. , Orth A.P. , Miraglia L. , Meltzer J. , Garza D. , Chirn G.-W. , McWhinnie E. , Cohen D. , Skelton J. , Terry R. , Yu Y. , Bodian D. , Buxton F.P. , more...
Proc. Natl. Acad. Sci. U.S.A.100:12147-12152(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRTC3
18.

"The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector."
Screaton R.A. , Conkright M.D. , Katoh Y. , Best J.L. , Canettieri G. , Jeffries S. , Guzman E. , Niessen S. , Yates J.R. III , Takemori H. , Okamoto M. , Montminy M.
Cell119:61-74(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRTC2
19.

"A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription."
Kang J. , Shi Y. , Xiang B. , Qu B. , Su W. , Zhu M. , Zhang M. , Bao G. , Wang F. , Zhang X. , Yang R. , Fan F. , Chen X. , Pei G. , Ma L.
Cell123:833-847(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB1
20.

"Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB."
David S. , Kalb R.G.
FEBS Lett.579:1534-1538(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-133 BY SGK1;INTERACTION WITH SGK1
21.

"PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth."
Vercauteren K. , Pasko R.A. , Gleyzer N. , Marino V.M. , Scarpulla R.C.
Mol. Cell. Biol.26:7409-7419(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPRC1
22.

"EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma."
Antonescu C.R. , Dal Cin P. , Nafa K. , Teot L.A. , Surti U. , Fletcher C.D. , Ladanyi M.
Genes Chromosomes Cancer46:1051-1060(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH EWSR1;ASSOCIATION WITH ANGIOMATOID FIBROUS HISTIOCYTOMA
23.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
24.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
25.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
26.

"Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271."
Sakamoto K. , Huang B.-W. , Iwasaki K. , Hailemariam K. , Ninomiya-Tsuji J. , Tsuji Y.
Mol. Biol. Cell21:2966-2974(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-271 BY HIPK2;MUTAGENESIS OF SER-271;INTERACTION WITH HIPK2
27.

"TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex."
Dittmer S. , Kovacs Z. , Yuan S.H. , Siszler G. , Kogl M. , Summer H. , Geerts A. , Golz S. , Shioda T. , Methner A.
J. Cell Sci.124:252-260(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TOX3;MUTAGENESIS OF SER-133
28.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
29.

"A p.D116G mutation in CREB1 leads to novel multiple malformation syndrome resembling CrebA knockout mouse."
Kitazawa S. , Kondo T. , Mori K. , Yokoyama N. , Matsuo M. , Kitazawa R.
Hum. Mutat.33:651-654(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN MULTIPLE CONGENITAL ANOMALIES;VARIANT GLY-116;CHARACTERIZATION OF VARIANT GLY-116

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