Gene name:
CRHR1 (CRFR;CRFR1;CRHR) ;
Protein name:
Corticotropin-releasing factor receptor 1 (CRF-R-1;CRF-R1;CRFR-1) ;
Alternative:
Corticotropin-releasing hormone receptor 1 (CRH-R-1;CRH-R1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via N-terminal extracellular domain) with CRF and UCN.
Function:
Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MGGHPQLRLV | KALLLLGLNP | VSASLQDQHC | ESLSLASNIS | GLQCNASVDL |
100:
IGTCWPRSPA | GQLVVRPCPA | FFYGVRYNTT | NNGYRECLAN | GSWAARVNYS |
150:
ECQEILNEEK | KSKVHYHVAV | IINYLGHCIS | LVALLVAFVL | FLRLRPGCTH |
200:
WGDQADGALE | VGAPWSGAPF | QVRRSIRCLR | NIIHWNLISA | FILRNATWFV |
250:
VQLTMSPEVH | QSNVGWCRLV | TAAYNYFHVT | NFFWMFGEGC | YLHTAIVLTY |
300:
STDRLRKWMF | ICIGWGVPFP | IIVAWAIGKL | YYDNEKCWFG | KRPGVYTDYI |
350:
YQGPMILVLL | INFIFLFNIV | RILMTKLRAS | TTSETIQYRK | AVKATLVLLP |
400:
LLGITYMLFF | VNPGEDEVSR | VVFIYFNSFL | ESFQGFFVSV | FYCFLNSEVR |
444:
SAIRKRWHRW | QDKHSIRARV | ARAMSIPTSP | TRVSFHSIKQ | STAV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Chicken
Mouse
ELISA Kit for Human CRF-R-1
ELISA Kit for Human CRF-R-1
ELISA Kit for Human CRF-R-1
ELISA Kit for Human CRF-R-1
CLIA Kit for Human CRF-R-1
CLIA Kit for Human CRF-R-1
CLIA Kit for Human CRF-R-1
CLIA Kit for Human CRF-R-1
Polyclonal Antibody for Human CRF-R-1
Polyclonal Antibody for Human CRF-R-1
Polyclonal Antibody for Human CRF-R-1
Polyclonal Antibody for Human CRF-R-1
Monoclonal Antibody for Human CRF-R-1
Monoclonal Antibody for Human CRF-R-1
Monoclonal Antibody for Human CRF-R-1
Monoclonal Antibody for Human CRF-R-1
Protein for Human CRF-R-1
Protein for Human CRF-R-1
Protein for Human CRF-R-1
Protein for Human CRF-R-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRF-R2)
13.
"Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor."
Perrin M.H.
,
Fischer W.H.
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Kunitake K.S.
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Craig A.G.
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Koerber S.C.
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Cervini L.A.
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J. Biol. Chem.276:31528-31534(2001)
[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 24-31;DISULFIDE BONDS
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-330
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CRF AND UCN
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH DLG1
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 24-119 IN COMPLEX WITH CRH;FUNCTION;DISULFIDE BONDS
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 25-109 IN COMPLEX WITH SYNTHETIC CRH ANALOG
20.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.98 ANGSTROMS) OF 104-373 IN COMPLEX WITH THE SYNTHETIC ANTAGONIST CP-376395;FUNCTION;SUBCELLULAR LOCATION;MEMBRANE TOPOLOGY;DISULFIDE BOND;ANTAGONIST BINDING SITES;MUTAGENESIS OF PHE-232; MET-235; LEU-309; ASN-312; PHE-313; LEU-316; ILE-319; TYR-356 AND GLN-384