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Index > Protein center > CRHR1(Gene name) > Human
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  • CRHR1 (Gene name),
  • Corticotropin-releasing factor receptor 1 (Protein name ),  CRFR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CRHR1(CRFR;CRFR1;CRHR);
    Protein name:
    Corticotropin-releasing factor receptor 1(CRF-R-1;CRF-R1;CRFR-1);
    Alternative:
    Corticotropin-releasing hormone receptor 1(CRH-R-1;CRH-R1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via N-terminal extracellular domain) with CRF and UCN.
    Function:
    Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    444
    Sequence:
    50:
    MGGHPQLRLV | KALLLLGLNP | VSASLQDQHC | ESLSLASNIS | GLQCNASVDL | 
    100:
    IGTCWPRSPA | GQLVVRPCPA | FFYGVRYNTT | NNGYRECLAN | GSWAARVNYS | 
    150:
    ECQEILNEEK | KSKVHYHVAV | IINYLGHCIS | LVALLVAFVL | FLRLRPGCTH | 
    200:
    WGDQADGALE | VGAPWSGAPF | QVRRSIRCLR | NIIHWNLISA | FILRNATWFV | 
    250:
    VQLTMSPEVH | QSNVGWCRLV | TAAYNYFHVT | NFFWMFGEGC | YLHTAIVLTY | 
    300:
    STDRLRKWMF | ICIGWGVPFP | IIVAWAIGKL | YYDNEKCWFG | KRPGVYTDYI | 
    350:
    YQGPMILVLL | INFIFLFNIV | RILMTKLRAS | TTSETIQYRK | AVKATLVLLP | 
    400:
    LLGITYMLFF | VNPGEDEVSR | VVFIYFNSFL | ESFQGFFVSV | FYCFLNSEVR | 
    444:
    SAIRKRWHRW | QDKHSIRARV | ARAMSIPTSP | TRVSFHSIKQ | STAV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    MIM:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human CRF-R-1
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    ELISA Kit for Human CRF-R-1
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    ELISA Kit for Human CRF-R-1
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    E1168c
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    ELISA Kit for Human CRF-R-1
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    CLIA Kit for Human CRF-R-1
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    CLIA Kit for Human CRF-R-1
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    Polyclonal Antibody for Human CRF-R-1
    Cat.:
    P1168Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CRF-R-1
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    P1168Rb-h
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    Polyclonal Antibody for Human CRF-R-1
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    P1168Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CRF-R-1
    Monoclonal Antibody for Human CRF-R-1
    Monoclonal Antibody for Human CRF-R-1
    Monoclonal Antibody for Human CRF-R-1
    Monoclonal Antibody for Human CRF-R-1
    Protein for Human CRF-R-1
    Protein for Human CRF-R-1
    Protein for Human CRF-R-1
    Protein for Human CRF-R-1

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    References
    1. 1.
      "Expression cloning of a human corticotropin-releasing-factor receptor."
      Chen R. , Lewis K.A. , Perrin M.H. , Vale W.W.
      Proc. Natl. Acad. Sci. U.S.A.90:8967-8971(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CRF-R1 AND CRF-R2)
      tissue: Pituitary.
    2. 2.
      "Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors."
      Vita N. , Laurent P. , Lefort S. , Chalon P. , Lelias J.-M. , Kaghad M. , le Fur G. , Caput D. , Ferrara P.
      FEBS Lett.335:1-5(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CRF-R2);TISSUE SPECIFICITY
      tissue: Brain.
    3. 3.
      "The genomic organization of the human corticotropin-releasing factor type-1 receptor."
      Sakai K. , Yamada M. , Horiba N. , Wakui M. , Demura H. , Suda T.
      Gene219:125-130(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "A variant of the human corticotropin-releasing factor (CRF) receptor: cloning, expression and pharmacology."
      Ross P.C. , Kostas C.M. , Ramabhadran T.V.
      Biochem. Biophys. Res. Commun.205:1836-1842(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CRF-R3)
      tissue: Hippocampus.
    5. 5.
      "A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes."
      Grammatopoulos D.K. , Dai Y. , Randeva H.S. , Levine M.A. , Karteris E. , Easton A.J. , Hillhouse E.W.
      Mol. Endocrinol.13:2189-2202(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CRF-R4)
    6. 6.
      "A novel CRF1 splice isoform involved in neurodegenerative and stress disorders."
      Sherrin T. , Murthy S.R. , Spiess J.
      Submitted (2008-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
    7. 7.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRF-R2)
      tissue: Brain.
    8. 8.
      "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
      Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRF-R2)
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
      tissue: Hippocampus.
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRF-R2)
    12. 13.
      "Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor."
      Perrin M.H. , Fischer W.H. , Kunitake K.S. , Craig A.G. , Koerber S.C. , Cervini L.A. , Rivier J.E. , Groppe J.C. , Greenwald J. , Moller Nielsen S. , Vale W.W.
      J. Biol. Chem.276:31528-31534(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-31;DISULFIDE BONDS
    13. 14.
      "Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity."
      Papadopoulou N. , Chen J. , Randeva H.S. , Levine M.A. , Hillhouse E.W. , Grammatopoulos D.K.
      Mol. Endocrinol.18:624-639(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-330
    14. 15.
      "Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels."
      Tao J. , Hildebrand M.E. , Liao P. , Liang M.C. , Tan G. , Li S. , Snutch T.P. , Soong T.W.
      Mol. Pharmacol.73:1596-1609(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    15. 16.
      "Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
      Pal K. , Swaminathan K. , Xu H.E. , Pioszak A.A.
      J. Biol. Chem.285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRF AND UCN
    16. 17.
      "Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling."
      Dunn H.A. , Walther C. , Godin C.M. , Hall R.A. , Ferguson S.S.
      J. Biol. Chem.288:15023-15034(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH DLG1
    17. 18.
      "Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1."
      Pioszak A.A. , Parker N.R. , Suino-Powell K. , Xu H.E.
      J. Biol. Chem.283:32900-32912(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 24-119 IN COMPLEX WITH CRH;FUNCTION;DISULFIDE BONDS
    18. 19.
      "NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist."
      Grace C.R. , Perrin M.H. , Gulyas J. , Rivier J.E. , Vale W.W. , Riek R.
      J. Biol. Chem.285:38580-38589(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 25-109 IN COMPLEX WITH SYNTHETIC CRH ANALOG
    19. 20.
      "Structure of class B GPCR corticotropin-releasing factor receptor 1."
      Hollenstein K. , Kean J. , Bortolato A. , Cheng R.K. , Dore A.S. , Jazayeri A. , Cooke R.M. , Weir M. , Marshall F.H.
      Nature499:438-443(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.98 ANGSTROMS) OF 104-373 IN COMPLEX WITH THE SYNTHETIC ANTAGONIST CP-376395;FUNCTION;SUBCELLULAR LOCATION;MEMBRANE TOPOLOGY;DISULFIDE BOND;ANTAGONIST BINDING SITES;MUTAGENESIS OF PHE-232; MET-235; LEU-309; ASN-312; PHE-313; LEU-316; ILE-319; TYR-356 AND GLN-384
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