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Index > Protein center > Crb1(Gene name) > Mouse
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  • Crb1 (Gene name),
  • Crumbs homolog 1 (Protein name ),  CRUM1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Crb1;
    Protein name:
    Crumbs homolog 1;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    In photoreceptor cells, forms a complex with MPDZ, MPP4 and MPP5.
    Function:
    Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion. Isoform 3 could play a role in epidermal tissue morphogenesis. May function in cell attachment for stratified epithelial organization.
    Subcellular Location:
    Isoform 1 Membrane Single-pass type I membrane protein In the retina, localizes to the Mueller cell radial processes in the inner nuclear layer and in apical processes sclerad to the external limiting membrane. Localizes to the subapical region, adjacent to the adherens junction of photoreceptors. Isoform 3 which is secreted is found in the cytoplasmic area of undifferentiated keratinocytes and associates with the plasma membrane at the site of cell-cell contacts and focal adhesion upon keratinocytes differentiation.
    Protein Attributes:
    Sequence length:
    1405
    Sequence:
    50:
    MKLKRTAYLL | FLYLSSSLLI | CIKNSFCNKN | NTRCLSGPCQ | NNSTCKHFPQ | 
    100:
    DNNCCLDTAN | NLDKDCEDLK | DPCFSSPCQG | IATCVKIPGE | GNFLCQCPPG | 
    150:
    YSGLNCETAT | NSCGGNLCQH | GGTCRKDPEH | PVCICPPGYA | GRFCETDHNE | 
    200:
    CASSPCHNGA | MCQDGINGYS | CFCVPGYQGR | HCDLEVDECV | SDPCKNEAVC | 
    250:
    LNEIGRYTCV | CPQEFSGVNC | ELEIDECRSQ | PCLHGATCQD | APGGYSCDCA | 
    300:
    PGFLGEHCEL | SVNECESQPC | LHGGLCVDGR | NSYHCDCTGS | GFTGMHCESL | 
    350:
    IPLCWSKPCH | NDATCEDTVD | SYICHCRPGY | TGALCETDIN | ECSSNPCQFW | 
    400:
    GECVELSSEG | LYGNTAGLPS | SFSYVGASGY | VCICQPGFTG | IHCEEDVDEC | 
    450:
    LLHPCLNGGT | CENLPGNYAC | HCPFDDTSRT | FYGGENCSEI | LLGCTHHQCL | 
    500:
    NNGKCIPHFQ | NGQHGFTCQC | LSGYAGPLCE | TVTTLSFGSN | GFLWVTSGSH | 
    550:
    TGIGPECNIS | LRFHTVQPNA | LLLIRGNKDV | SMKLELLNGC | VHLSIEVWNQ | 
    600:
    LKVLLSISHN | TSDGEWHFVE | VTIAETLTLA | LVGGSCKEKC | TTKSSVPVEN | 
    650:
    HQSICALQDS | FLGGLPMGTA | NNSVSVLNIY | NVPSTPSFVG | CLQDIRFDLN | 
    700:
    HITLENVSSG | LSSNVKAGCL | GKDWCESQPC | QNRGRCINLW | QGYQCECDRP | 
    750:
    YTGSNCLKEY | VAGRFGQDDS | TGYAAFSVND | NYGQNFSLSM | FVRTRQPLGL | 
    800:
    LLALENSTYQ | YVSVWLEHGS | LALQTPGSPK | FMVNFFLSDG | NVHLISLRIK | 
    850:
    PNEIELYQSS | QNLGFISVPT | WTIRRGDVIF | IGGLPDREKT | EVYGGFFKGC | 
    900:
    VQDVRLNSQT | LEFFPNSTNN | AYDDPILVNV | TQGCPGDNTC | KSNPCHNGGV | 
    950:
    CHSLWDDFSC | SCPTNTAGRA | CEQVQWCQLS | PCPPTAECQL | LPQGFECIAN | 
    1000:
    AVFSGLSREI | LFRSNGNITR | ELTNITFAFR | THDTNVMILH | AEKEPEFLNI | 
    1050:
    SIQDARLFFQ | LRSGNSFYTL | HLMGSQLVND | GTWHQVTFSM | IDPVAQTSRW | 
    1100:
    QMEVNDQTPF | VISEVATGSL | NFLKDNTDIY | VGDQSVDNPK | GLQGCLSTIE | 
    1150:
    IGGIYLSYFE | NLHGFPGKPQ | EEQFLKVSTN | MVLTGCLPSN | ACHSSPCLHG | 
    1200:
    GNCEDSYSSY | RCACLSGWSG | THCEINIDEC | FSSPCIHGNC | SDGVAAYHCR | 
    1250:
    CEPGYTGVNC | EVDVDNCKSH | QCANGATCVP | EAHGYSCLCF | GNFTGRFCRH | 
    1300:
    SRLPSTVCGN | EKRNFTCYNG | GSCSMFQEDW | QCMCWPGFTG | EWCEEDINEC | 
    1350:
    ASDPCINGGL | CRDLVNRFLC | ICDVAFAGER | CELDLADDRL | LGIFTAVGSG | 
    1400:
    TLALFFILLL | AGVASLIASN | KRATQGTYSP | SGQEKAGPRV | EMWIRMPPPA | 
    1405:
    LERLI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Crumbs homolog 1
    ELISA Kit for Mouse Crumbs homolog 1
    CLIA Kit for Mouse Crumbs homolog 1
    CLIA Kit for Mouse Crumbs homolog 1
    Polyclonal Antibody for Mouse Crumbs homolog 1
    Polyclonal Antibody for Mouse Crumbs homolog 1
    Monoclonal Antibody for Mouse Crumbs homolog 1
    Monoclonal Antibody for Mouse Crumbs homolog 1
    Protein for Mouse Crumbs homolog 1
    Protein for Mouse Crumbs homolog 1

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain."
      den Hollander A.I. , Ghiani M. , de Kok Y.J.M. , Wijnholds J. , Ballabio A. , Cremers F.P.M. , Broccoli V.
      Mech. Dev.110:203-207(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION
      tissue: Eye.
    2. 2.
      "Expression of a novel secretory form (Crb1s) of mouse Crumbs homologue Crb1 in skin development."
      Watanabe T. , Miyatani S. , Katoh I. , Kobayashi S. , Ikawa Y.
      Biochem. Biophys. Res. Commun.313:263-270(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;FUNCTION
      strain: ICR.
      tissue: Skin.
    3. 3.
      "Mouse Crumbs-2 in developing nervous system."
      Chang C.-H. , Fan S.-S.
      Submitted (2002-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: ICR.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      strain: C57BL/6J.
      tissue: Retina.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    6. 6.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis."
      Pellikka M. , Tanentzapf G. , Pinto M. , Smith C. , McGlade C.J. , Ready D.F. , Tepass U.
      Nature416:143-149(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    8. 8.
      "CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina."
      Mehalow A.K. , Kameya S. , Smith R.S. , Hawes N.L. , Denegre J.M. , Young J.A. , Bechtold L. , Haider N.B. , Tepass U. , Heckenlively J.R. , Chang B. , Naggert J.K. , Nishina P.M.
      Hum. Mol. Genet.12:2179-2189(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DISEASE;FUNCTION
    9. 9.
      "Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure."
      van de Pavert S.A. , Kantardzhieva A. , Malysheva A. , Meuleman J. , Versteeg I. , Levelt C. , Klooster J. , Geiger S. , Seeliger M.W. , Rashbass P. , Le Bivic A. , Wijnholds J.
      J. Cell Sci.117:4169-4177(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;COMPLEX FORMATION WITH MPDZ; MPP4 AND MPP5;FUNCTION
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