Protein name:
Cryptochrome-1 ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts with FBXL21 (By similarity). Interacts directly with TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Binds MAPK. Interacts with FBXL3.
Function:
Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.
Subcellular Location:
Cytoplasm
Nucleus
Transloctaed to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.
Protein Attributes:
50:
MGVNAVHWFR | KGLRLHDNPA | LKECIQGADT | IRCVYILDPW | FAGSSNVGIN |
100:
RWRFLLQCLE | DLDANLRKLN | SRLFVIRGQP | ADVFPRLFKE | WNITKLSIEY |
150:
DSEPFGKERD | AAIKKLATEA | GVEVIVRISH | TLYDLDKIIE | LNGGQPPLTY |
200:
KRFQTLVSKM | EPLEMPADTI | TSDVIGKCMT | PLSDDHDEKY | GVPSLEELGF |
250:
DTDGLSSAVW | PGGETEALTR | LERHLERKAW | VANFERPRMN | ANSLLASPTG |
300:
LSPYLRFGCL | SCRLFYFKLT | DLYKKVKKNS | SPPLSLYGQL | LWREFFYTAA |
350:
TNNPRFDKME | GNPICVQIPW | DKNPEALAKW | AEGRTGFPWI | DAIMTQLRQE |
400:
GWIHHLARHA | VACFLTRGDL | WISWEEGMKV | FEELLLDADW | SINAGSWMWL |
450:
SCSSFFQQFF | HCYCPVGFGR | RTDPNGDYIR | RYLPVLRGFP | AKYIYDPWNA |
500:
PEGIQKVAKC | LIGVNYPKPM | VNHAEASRLN | IERMKQIYQQ | LSRYRGLGLL |
550:
ASVPSNSNGN | GGLMGYAPGE | NVPSCSSSGN | GGLMGYAPGE | NVPSCSGGNC |
600:
SQGSGILHYA | HGDSQQTHSL | KQGRSSAGTG | LSSGKRPSQE | EDAQSVGPKV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Chicken
ELISA Kit for Mouse Cryptochrome-1
ELISA Kit for Mouse Cryptochrome-1
ELISA Kit for Mouse Cryptochrome-1
ELISA Kit for Mouse Cryptochrome-1
CLIA Kit for Mouse Cryptochrome-1
CLIA Kit for Mouse Cryptochrome-1
CLIA Kit for Mouse Cryptochrome-1
CLIA Kit for Mouse Cryptochrome-1
Polyclonal Antibody for Mouse Cryptochrome-1
Polyclonal Antibody for Mouse Cryptochrome-1
Polyclonal Antibody for Mouse Cryptochrome-1
Polyclonal Antibody for Mouse Cryptochrome-1
Monoclonal Antibody for Mouse Cryptochrome-1
Monoclonal Antibody for Mouse Cryptochrome-1
Monoclonal Antibody for Mouse Cryptochrome-1
Monoclonal Antibody for Mouse Cryptochrome-1
Protein for Mouse Cryptochrome-1
Protein for Mouse Cryptochrome-1
Protein for Mouse Cryptochrome-1
Protein for Mouse Cryptochrome-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue :
Brain .
tissue :
Keratinocyte .
tissue :
Liver .
2.
"Analysis of mouse cryptochromes."
Kume K.
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Reppert S.M.
Submitted (1999-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6 .
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"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Embryo .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
strain :
FVB/N .
tissue :
Brain .
tissue :
Embryonic brain .
tissue :
Mammary tumor .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INDUCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PER1; PER2; PER3 AND TIMELESS;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INDUCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PER2;SUBCELLULAR LOCATION;UBIQUITINATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PER1 AND PER2;PHOSPHORYLATION;SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-247;MUTAGENESIS OF SER-247
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PER1; PER2 AND PER3
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS TRANSCRIPTION REPRESSOR;INTERACTION WITH HDAC1; HDAC2 AND SIN3B
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH EZH2; CLOCK AND ARNTL
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PER1 AND PER2;SUBCELLULAR LOCATION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INDUCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FBXL3;UBIQUITINATION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FBXL21;UBIQUITINATION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ARNTL AND CLOCK;INDUCTION
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MYBBP1A; DOCK7; HNRNPU; RPL7A; RPL8 AND RPS3
22.
"AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation."
Lamia K.A.
,
Sachdeva U.M.
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DiTacchio L.
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Williams E.C.
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Alvarez J.G.
,
Egan D.F.
,
Vasquez D.S.
,
Juguilon H.
,
Panda S.
,
Shaw R.J.
,
Thompson C.B.
,
Evans R.M.
Science326:437-440(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-71 AND SER-280;MUTAGENESIS OF SER-71 AND SER-280
23.
"Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis."
Ramsey K.M.
,
Yoshino J.
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Brace C.S.
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Science324:651-654(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PER2
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
26.
"Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis."
Zhang E.E.
,
Liu Y.
,
Dentin R.
,
Pongsawakul P.Y.
,
Liu A.C.
,
Hirota T.
,
Nusinow D.A.
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Sun X.
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Landais S.
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Kodama Y.
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Brenner D.A.
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Montminy M.
,
Kay S.A.
Nat. Med.16:1152-1156(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN GLUCONEOGENESIS;DISRUPTION PHENOTYPE
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN CIRCADIAN RHYTHMS REGULATION;INDUCTION
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ARNTL; CLOCK AND PER2
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS NR3C1 REPRESSOR;INTERACTION WITH AR; NR1D1; NR3C1; RORA AND RORC;DISRUPTION PHENOTYPE
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION;INTERACTION WITH PRMT5
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN METABOLISM;DISRUPTION PHENOTYPE
33.
"Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm."
Yoo S.H.
,
Mohawk J.A.
,
Siepka S.M.
,
Shan Y.
,
Huh S.K.
,
Hong H.K.
,
Kornblum I.
,
Kumar V.
,
Koike N.
,
Xu M.
,
Nussbaum J.
,
Liu X.
,
Chen Z.
,
Chen Z.J.
,
Green C.B.
,
Takahashi J.S.
Cell152:1091-1105(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION BY THE SCF(FBXL3) AND SCF(FBXL21) COMPLEXES;INTERACTION WITH FBXL3 AND FBXL21;UBIQUITINATION AT LYS-11
34.
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Cited for : UBIQUITINATION BY THE SCF(FBXL3) AND SCF(FBXL21) COMPLEXES;UBIQUITINATION AT LYS-107; LYS-159; LYS-329 AND LYS-485;INTERACTION WITH FBXL3 AND FBXL21;MUTAGENESIS OF LYS-107
35.
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Cited for : FUNCTION IN CIRCADIAN CLOCK;INTERACTION WITH PRKDC;PHOSPHORYLATION AT SER-588;MUTAGENESIS OF SER-551; SER-564 AND SER-588
36.
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Cited for : FUNCTION IN CIRCADIAN CLOCK;DISRUPTION PHENOTYPE
37.
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Cited for : FUNCTION IN CIRCADIAN CLOCK
38.
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Cited for : FUNCTION
39.
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Cited for : INTERACTION WITH TIMELESS AND PER2;SUBCELLULAR LOCATION
40.
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Cited for : REVIEW
41.
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Cited for : FUNCTION;DISRUPTION PHENOTYPE
42.
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Cited for : FUNCTION IN GR REPRESSION
43.
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Cited for : FUNCTION IN DNA DAMAGE CHECKPOINT;INTERACTION WITH TIMELESS;SUBCELLULAR LOCATION
44.
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Cited for : REVIEW
45.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF APOPROTEIN;INTERACTION WITH ARNTL; PER2 AND FBXL3;FUNCTION;MUTAGENESIS OF HIS-224; SER-247; 382-GLU-GLU-383; PHE-405 AND LYS-485