CRYAA ELISA Kit for Human(Homo sapiens) | EIAab.comCRYAA ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CRYAA(Gene name) > Human

CRYAA (Gene name),

Alpha-crystallin A chain (Protein name ), CRYAA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

CRYAA(CRYA1;HSPB4);

Protein name:

Alpha-crystallin A chain;

Alternative:

Heat shock protein beta-4(HspB4);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

May contribute to the transparency and refractive index of the lens.

Subcellular Location:

Cytoplasm Nucleus Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.

Protein Attributes:

Sequence length:

173

Sequence:

50:

100:

150:

173:

DATHAERAIP | VSREEKPTSA | PSS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

MIM:

123580

String:

P02489

Pfam:

PF00525

KEGG:

hsa:1409

SMR:

P02489

UniGene:

Hs.184085

STRING:

9606.ENSP00000291554

Uniprot:

P02489

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ELISA Kit for Human Alpha-crystallin A chain

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E1455h

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ELISA Kit for Human Alpha-crystallin A chain

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ELISA Kit for Human Alpha-crystallin A chain

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E1455m

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96T

ELISA Kit for Human Alpha-crystallin A chain

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E1455r

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96T

ELISA Kit for Human Alpha-crystallin A chain

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E1455b

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96T

ELISA Kit for Human Alpha-crystallin A chain

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E1455d

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96T

ELISA Kit for Human Alpha-crystallin A chain

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E1455p

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96T

ELISA Kit for Human Alpha-crystallin A chain

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E1455c

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96T

CLIA Kit for Human Alpha-crystallin A chain

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U1455h

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96T

CLIA Kit for Human Alpha-crystallin A chain

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U1455m

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96T

CLIA Kit for Human Alpha-crystallin A chain

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U1455p

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96T

CLIA Kit for Human Alpha-crystallin A chain

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U1455d

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96T

CLIA Kit for Human Alpha-crystallin A chain

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U1455c

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96T

CLIA Kit for Human Alpha-crystallin A chain

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CLIA Kit for Human Alpha-crystallin A chain

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U1455b

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96T

CLIA Kit for Human Alpha-crystallin A chain

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U1455r

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96T

Polyclonal Antibody for Human Alpha-crystallin A chain

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P1455Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Alpha-crystallin A chain

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P1455Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Alpha-crystallin A chain

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P1455Rb-h

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Monoclonal Antibody for Human Alpha-crystallin A chain

Protein for Human Alpha-crystallin A chain

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"Proteomic analysis of the aqueous humor in patients with wet age‐related macular degeneration"

J Yao, X Liu, Q Yang, M Zhuang, F Wang

From:Proteomics Clinical Applications

References

1.

"The amino acid sequence of the A chain of human alpha-crystallin."
de Jong W.W. , Terwindt E.C. , Bloemendal H.
FEBS Lett.58:310-313(1975) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY PROTEIN SEQUENCE;ACETYLATION AT MET-1
2.

"A reassessment of mammalian alpha A-crystallin sequences using DNA sequencing: implications for anthropoid affinities of tarsier."
Jaworski C.J.
J. Mol. Evol.41:901-908(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Lens.
3.

"Cloning, expression, and chaperone-like activity of human alphaA-crystallin."
Andley U.P. , Mathur S. , Griest T.A. , Petrash J.M.
J. Biol. Chem.271:31973-31980(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Lens.
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
8.

"A pseudo-exon in the functional human alpha A-crystallin gene."
Jaworski C.J. , Piatigorsky J.
Nature337:752-754(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-104
9.

"Isolation and partial characterization of the human alpha A-crystallin gene."
McDevitt D.S. , Hawkins J.W. , Jaworski C.J. , Piatigorsky J.
Exp. Eye Res.43:285-291(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63 AND 166-173
tissue: Spleen.
10.

"Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."
Lampi K.J. , Ma Z. , Shih M. , Shearer T.R. , Smith J.B. , Smith D.L. , David L.L.
J. Biol. Chem.272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 13-21 AND 79-88
11.

"Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine."
Roquemore E.P. , Dell A. , Morris H.R. , Panico M. , Reason A.J. , Savoy L.-A. , Wistow G.J. , Zigler J.S. Jr. , Earles B.J. , Hart G.W.
J. Biol. Chem.267:555-563(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF CARBOHYDRATE
12.

"Post-translational modifications of water-soluble human lens crystallins from young adults."
Miesbauer L.R. , Zhou X. , Yang Z. , Yang Z. , Sun Y. , Smith D.L. , Smith J.B.
J. Biol. Chem.269:12494-12502(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-122;DISULFIDE BOND;PROTEOLYTIC PROCESSING OF C-TERMINAL;DEAMIDATION AT ASN-101;MASS SPECTROMETRY
13.

"Differential phosphorylation of alpha-A crystallin in human lens of different age."
Takemoto L.J.
Exp. Eye Res.62:499-504(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-122
14.

"Modifications of the water-insoluble human lens alpha-crystallins."
Lund A.L. , Smith J.B. , Smith D.L.
Exp. Eye Res.63:661-672(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;SUSCEPTIBILITY TO OXIDATION;PHOSPHORYLATION AT SER-45 AND SER-122;DISULFIDE BOND;DEAMIDATION AT GLN-6; GLN-50; GLN-90; ASN-101 AND GLN-147;IDENTIFICATION BY MASS SPECTROMETRY
15.

"Quantitation of asparagine-101 deamidation from alpha-A crystallin during aging of the human lens."
Takemoto L.J.
Curr. Eye Res.17:247-250(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEAMIDATION AT ASN-101
16.

"In vivo acetylation identified at lysine 70 of human lens alphaA-crystallin."
Lin P.P. , Barry R.C. , Smith D.L. , Smith J.B.
Protein Sci.7:1451-1457(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING OF C-TERMINAL;ACETYLATION AT LYS-70;PHOSPHORYLATION;DEAMIDATION AT ASN-101;MASS SPECTROMETRY
17.

"The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage."
Hanson S.R.A. , Hasan A. , Smith D.L. , Smith J.B.
Exp. Eye Res.71:195-207(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;SUSCEPTIBILITY TO OXIDATION;PROTEOLYTIC PROCESSING OF C-TERMINAL;MASS SPECTROMETRY
18.

"Chaperone-like activity of alpha-crystallin and other small heat shock proteins."
Ganea E.
Curr. Protein Pept. Sci.2:205-225(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
19.

"Enhanced C-terminal truncation of alphaA- and alphaB-crystallins in diabetic lenses."
Thampi P. , Hassan A. , Smith J.B. , Abraham E.C.
Invest. Ophthalmol. Vis. Sci.43:3265-3272(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;TISSUE SPECIFICITY
20.

"Structural and functional roles of deamidation and/or truncation of N- or C-termini in human alpha A-crystallin."
Chaves J.M. , Srivastava K. , Gupta R. , Srivastava O.P.
Biochemistry47:10069-10083(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEAMIDATION AT ASN-123;MUTAGENESIS OF ASN-123
21.

"C-Terminal truncation affects subunit exchange of human alphaA-crystallin with alphaB-crystallin."
Kallur L.S. , Aziz A. , Abraham E.C.
Mol. Cell. Biochem.308:85-91(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
22.

"HSPB7 is a SC35 speckle resident small heat shock protein."
Vos M.J. , Kanon B. , Kampinga H.H.
Biochim. Biophys. Acta1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
23.

"Importance of eye lens alpha-crystallin heteropolymer with 3:1 alphaA to alphaB ratio: stability, aggregation, and modifications."
Srinivas P. , Narahari A. , Petrash J.M. , Swamy M.J. , Reddy G.B.
IUBMB Life62:693-702(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
24.

"Acetylation of alphaA-crystallin in the human lens: effects on structure and chaperone function."
Nagaraj R.H. , Nahomi R.B. , Shanthakumar S. , Linetsky M. , Padmanabha S. , Pasupuleti N. , Wang B. , Santhoshkumar P. , Panda A.K. , Biswas A.
Biochim. Biophys. Acta1822:120-129(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACETYLATION AT LYS-70 AND LYS-99
25.

"Identification of histidine residues involved in Zn(2+) binding to alphaA- and alphaB-Crystallin by chemical modification and MALDI TOF mass spectrometry."
Karmakar S. , Das K.P.
Protein J.31:623-640(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;ZINC-BINDING SITES
26.

"Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA."
Litt M. , Kramer P. , la Morticella D.M. , Murphey W. , Lovrien E.W. , Weleber R.G.
Hum. Mol. Genet.7:471-474(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CTRCT9 CYS-116
27.

"Structural and functional changes in the alpha A-crystallin R116C mutant in hereditary cataracts."
Cobb B.A. , Petrash J.M.
Biochemistry39:15791-15798(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT CTRCT9 CYS-116
28.

"Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q."
Mackay D.S. , Andley U.P. , Shiels A.
Eur. J. Hum. Genet.11:784-793(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CTRCT9 CYS-49
29.

"Congenital cataract and macular hypoplasia in humans associated with a de novo mutation in CRYAA and compound heterozygous mutations in P."
Graw J. , Klopp N. , Illig T. , Preising M.N. , Lorenz B.
Graefes Arch. Clin. Exp. Ophthalmol.244:912-919(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CTRCT9 LEU-21
30.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-105
31.

"Clinical variability of autosomal dominant cataract, microcornea and corneal opacity and novel mutation in the alpha A crystallin gene (CRYAA)."
Richter L. , Flodman P. , Barria von-Bischhoffshausen F. , Burch D. , Brown S. , Nguyen L. , Turner J. , Spence M.A. , Bateman J.B.
Am. J. Med. Genet. A146:833-842(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CTRCT9 HIS-116
32.

"A novel mutation in AlphaA-crystallin (CRYAA) caused autosomal dominant congenital cataract in a large Chinese family."
Gu F. , Luo W. , Li X. , Wang Z. , Lu S. , Zhang M. , Zhao B. , Zhu S. , Feng S. , Yan Y.-B. , Huang S. , Ma X.
Hum. Mutat.29:769-769(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CTRCT9 HIS-116;CHARACTERIZATION OF VARIANT CTRCT9 HIS-116
33.

"Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes."
Reis L.M. , Tyler R.C. , Muheisen S. , Raggio V. , Salviati L. , Han D.P. , Costakos D. , Yonath H. , Hall S. , Power P. , Semina E.V.
Hum. Genet.132:761-770(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CTRCT9 CYS-12

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