Protein name:
Alpha-crystallin B chain ;
Alternative:
Heat shock protein beta-5 (HspB5) ;Alpha(B)-crystallin ;Rosenthal fiber component ;Renal carcinoma antigen NY-REN-27 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Aggregates with homologous proteins, including CRYAA and the small heat shock protein HSPB1, to form large heteromeric complexes. Interacts with HSPBAP1 and TTN/titin.
Function:
May contribute to the transparency and refractive index of the lens.
Subcellular Location:
Cytoplasm
Nucleus
Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein Attributes:
50:
MDIAIHHPWI | RRPFFPFHSP | SRLFDQFFGE | HLLESDLFPT | STSLSPFYLR |
100:
PPSFLRAPSW | FDTGLSEMRL | EKDRFSVNLD | VKHFSPEELK | VKVLGDVIEV |
150:
HGKHEERQDE | HGFISREFHR | KYRIPADVDP | LTITSSLSSD | GVLTVNGPRK |
175:
QVSGPERTIP | ITREEKPAVT | AAPKK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
Rat
Pig
Rabbit
Chicken
ELISA Kit for Human Alpha-crystallin B chain
ELISA Kit for Human Alpha-crystallin B chain
ELISA Kit for Human Alpha-crystallin B chain
ELISA Kit for Human Alpha-crystallin B chain
ELISA Kit for Human Alpha-crystallin B chain
ELISA Kit for Human Alpha-crystallin B chain
ELISA Kit for Human Alpha-crystallin B chain
CLIA Kit for Human Alpha-crystallin B chain
CLIA Kit for Human Alpha-crystallin B chain
CLIA Kit for Human Alpha-crystallin B chain
CLIA Kit for Human Alpha-crystallin B chain
CLIA Kit for Human Alpha-crystallin B chain
CLIA Kit for Human Alpha-crystallin B chain
CLIA Kit for Human Alpha-crystallin B chain
Polyclonal Antibody for Human Alpha-crystallin B chain
Polyclonal Antibody for Human Alpha-crystallin B chain
Polyclonal Antibody for Human Alpha-crystallin B chain
Polyclonal Antibody for Human Alpha-crystallin B chain
Polyclonal Antibody for Human Alpha-crystallin B chain
Polyclonal Antibody for Human Alpha-crystallin B chain
Polyclonal Antibody for Human Alpha-crystallin B chain
Monoclonal Antibody for Human Alpha-crystallin B chain
Monoclonal Antibody for Human Alpha-crystallin B chain
Monoclonal Antibody for Human Alpha-crystallin B chain
Monoclonal Antibody for Human Alpha-crystallin B chain
Monoclonal Antibody for Human Alpha-crystallin B chain
Monoclonal Antibody for Human Alpha-crystallin B chain
Monoclonal Antibody for Human Alpha-crystallin B chain
Protein for Human Alpha-crystallin B chain
Protein for Human Alpha-crystallin B chain
Protein for Human Alpha-crystallin B chain
Protein for Human Alpha-crystallin B chain
Protein for Human Alpha-crystallin B chain
Protein for Human Alpha-crystallin B chain
Protein for Human Alpha-crystallin B chain
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PRELIMINARY PROTEIN SEQUENCE
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
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Tanikawa M.
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Kimata M.
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
,
Chen X.
,
Rolfs A.
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Halleck A.
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Hines L.
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Eisenstein S.
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Raphael J.
,
Moreira D.
,
Kelley T.
,
LaBaer J.
,
Lin Y.
,
Phelan M.
,
Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
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Halpern A.L.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Heart .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-24; 35-66 AND 118-175;ASSOCIATION WITH HSPB1
tissue :
Pectoralis muscle .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 57-66
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 83-89 AND 164-172
tissue :
Heart .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 107-175
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : RACEMIZATION/ISOMERIZATION OF SPECIFIC ASP
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-19; SER-45 AND SER-59;MASS SPECTROMETRY
16.
"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Scanlan M.J.
,
Gordan J.D.
,
Williamson B.
,
Stockert E.
,
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,
Jongeneel C.V.
,
Gure A.O.
,
Jaeger D.
,
Jaeger E.
,
Knuth A.
,
Chen Y.-T.
,
Old L.J.
Int. J. Cancer83:456-464(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION AS A RENAL CANCER ANTIGEN
tissue :
Renal cell carcinoma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MASS SPECTROMETRY;SUSCEPTIBILITY TO OXIDATION;PHOSPHORYLATION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HSPBAP1
19.
"Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans."
Berry V.
,
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Moore A.
,
Bhattacharya S.S.
,
Quinlan R.A.
Am. J. Hum. Genet.69:1141-1145(2001)
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PubMed ]
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Abstract ]
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Cited for : INVOLVEMENT IN CTRCT16
20.
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Cited for : PHOSPHORYLATION AT SER-45 AND SER-59
21.
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Cited for : ACETYLATION AT LYS-92
22.
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Cited for : INVOLVEMENT IN MFM2
23.
"Association of the chaperone alphaB-crystallin with titin in heart muscle."
Bullard B.
,
Ferguson C.
,
Minajeva A.
,
Leake M.C.
,
Gautel M.
,
Labeit D.
,
Ding L.
,
Labeit S.
,
Horwitz J.
,
Leonard K.R.
,
Linke W.A.
J. Biol. Chem.279:7917-7924(2004)
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PubMed ]
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Europe PMC ]
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Abstract ]
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Cited for : INTERACTION WITH TTN
24.
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Cited for : SUBCELLULAR LOCATION
25.
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Cited for : SUBUNIT
26.
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Cited for : INVOLVEMENT IN MFMFIH-CRYAB
27.
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Cited for : ACETYLATION AT LYS-92 AND LYS-166
28.
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Cited for : SUBUNIT;ZINC-BINDING SITES
29.
"A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy."
Vicart P.
,
Caron A.
,
Guicheney P.
,
Li Z.
,
Prevost M.-C.
,
Faure A.
,
Chateau D.
,
Chapon F.
,
Tome F.
,
Dupret J.-M.
,
Paulin D.
,
Fardeau M.
Nat. Genet.20:92-95(1998)
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Cited for : VARIANT MFM2 GLY-120
30.
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Cited for : CHARACTERIZATION OF VARIANTS MFM2 GLY-120
31.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) OF 67-157;HOMODIMERIZATION
32.
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Cited for : VARIANT CMD1II HIS-157
33.
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Cited for : VARIANT CMD1II SER-154
34.
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Cited for : VARIANT MFM2 HIS-109