Kcnip3 ELISA Kit for Mouse(Mus musculus) | EIAab.comKcnip3 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Kcnip3(Gene name) > Mouse

Kcnip3 (Gene name),

Calsenilin (Protein name ), CSEN_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Kcnip3(Csen;Dream;Kchip3);

Protein name:

Calsenilin;

Alternative:

DRE-antagonist modulator(DREAM);A-type potassium channel modulatory protein 3;Kv channel-interacting protein 3(KChIP3);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium. Interacts with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1. Component of heteromultimeric potassium channels (By similarity). Interacts with KCND2 and KCND3.

Function:

May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.

Subcellular Location:

Cytoplasm Cell membrane Lipid-anchor Endoplasmic reticulum Golgi apparatus Nucleus In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi.

Protein Attributes:

Sequence length:

256

Sequence:

50:

100:

150:

200:

250:

256:

LFENVI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9QXT8

KEGG:

mmu:56461

STRING:

10090.ENSMUSP00000028850

Pfam:

PF00036

Pfam:

PF13499

SMR:

Q9QXT8

UniGene:

Mm.315292

Uniprot:

Q9QXT8

FOR

ELISA Kit for Mouse Calsenilin

CLIA Kit for Mouse Calsenilin

Polyclonal Antibody for Mouse Calsenilin

Monoclonal Antibody for Mouse Calsenilin

Protein for Mouse Calsenilin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Mouse DREAM/calsenilin/KChIP3: gene structure, coding potential and expression."
Spreafico F. , Barski J.J. , Farina C. , Meyer M.
Mol. Cell. Neurosci.17:1-16(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3);NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY;VARIANT SER-14
strain: 129/Ola.
strain: C57BL/6.
2.

"Cloning and characterization of mouse calsenilin/DREAM."
Jo D.G. , Kim M. , Jung Y.K.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Allele of Mus musculus Dream/calsenilin gene."
Deng L. , Reid R.E. , Leavitt B. , Hayden M.R.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-14
strain: FVB/NJ.
tissue: Brain.
4.

Lee H.G. , Choi J.K. , Choi E.K. , Wasco W. , Buxbaum J.D. , Beier D.R. , Kim Y.S.
Submitted (2000-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-14
strain: BALB/c.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6.
tissue: Brain.
tissue: Eye.
tissue: Olfactory epithelium.
6.

"Modulation of A-type potassium channels by a family of calcium sensors."
An W.F. , Bowlby M.R. , Betty M. , Cao J. , Ling H.-P. , Mendoza G. , Hinson J.W. , Mattsson K.I. , Strassle B.W. , Trimmer J.S. , Rhodes K.J.
Nature403:553-556(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
7.

"Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription."
Liss B. , Franz O. , Sewing S. , Bruns R. , Neuhoff H. , Roeper J.
EMBO J.20:5715-5724(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCND3
8.

"DREAM is a critical transcriptional repressor for pain modulation."
Cheng H.Y. , Pitcher G.M. , Laviolette S.R. , Whishaw I.Q. , Tong K.I. , Kockeritz L.K. , Wada T. , Joza N.A. , Crackower M. , Goncalves J. , Sarosi I. , Woodgett J.R. , Oliveira-dos-Santos A.J. , Ikura M. , van der Kooy D. , Salter M.W. , Penninger J.M.
Cell108:31-43(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex."
Schrader L.A. , Anderson A.E. , Mayne A. , Pfaffinger P.J. , Sweatt J.D.
J. Neurosci.22:10123-10133(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCND2
10.

"Functional properties of a brain-specific NH2-terminally spliced modulator of Kv4 channels."
Boland L.M. , Jiang M. , Lee S.Y. , Fahrenkrug S.C. , Harnett M.T. , O'Grady S.M.
Am. J. Physiol.285:C161-C170(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
11.

"Altered Abeta formation and long-term potentiation in a calsenilin knock-out."
Lilliehook C. , Bozdagi O. , Yao J. , Gomez-Ramirez M. , Zaidi N.F. , Wasco W. , Gandy S. , Santucci A.C. , Haroutunian V. , Huntley G.W. , Buxbaum J.D.
J. Neurosci.23:9097-9106(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Differential distribution of KChIPs mRNAs in adult mouse brain."
Xiong H. , Kovacs I. , Zhang Z.
Brain Res. Mol. Brain Res.128:103-111(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
13.

"Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM."
Osawa M. , Dace A. , Tong K.I. , Valiveti A. , Ikura M. , Ames J.B.
J. Biol. Chem.280:18008-18014(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;CALCIUM-BINDING;SUBUNIT;MUTAGENESIS OF GLU-186 AND GLU-234
14.

"NMR structure of DREAM: implications for Ca(2+)-dependent DNA binding and protein dimerization."
Lusin J.D. , Vanarotti M. , Li C. , Valiveti A. , Ames J.B.
Biochemistry47:2252-2264(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR;SUBUNIT;DNA-BINDING;CALCIUM-BINDING

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