Csf1r ELISA Kit for Mouse(Mus musculus) | EIAab.comCsf1r ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Csf1r(Gene name) > Mouse

Csf1r (Gene name),

Macrophage colony-stimulating factor 1 receptor (Protein name ), CSF1R_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Csf1r(Csfmr;Fms);

Protein name:

Macrophage colony-stimulating factor 1 receptor(CSF-1-R);

Alternative:

Proto-oncogene c-Fms;2.7.10.1;Proto-oncogene c-Fms(CSF-1-R);

CD:

CD115;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with INPPL1/SHIP2 and THOC5.

Function:

Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

977

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

977:

SSSEHLACCE | PGDIAQPLLQ | PNNYQFC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.22574

Pfam:

PF07679

String:

P09581

KEGG:

mmu:12978

SMR:

P09581

Uniprot:

P09581

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ELISA Kit for Mouse CSF-1-R

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E1594h

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96T

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ELISA Kit for Mouse CSF-1-R

Cat.:

E1594m

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96T

ELISA Kit for Mouse CSF-1-R

Cat.:

E1594r

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96T

CLIA Kit for Mouse CSF-1-R

Cat.:

U1594h

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96T

CLIA Kit for Mouse CSF-1-R

Cat.:

U1594m

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96T

CLIA Kit for Mouse CSF-1-R

Cat.:

U1594r

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96T

Polyclonal Antibody for Mouse CSF-1-R

Cat.:

P1594Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse CSF-1-R

Cat.:

P1594Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse CSF-1-R

Cat.:

P1594Rb-r

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40ug/0.2ml

Monoclonal Antibody for Mouse CSF-1-R

Protein for Mouse CSF-1-R

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Murine c-fms cDNA: cloning, sequence analysis and retroviral expression."
Rothwell V.M. , Rohrschneider L.R.
Oncogene Res.1:311-324(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Rothwell V.M.
Submitted (1988-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
3.

"Reassessment of the murine c-fms proto-oncogene sequence."
de Parseval N. , Bordereaux D. , Gisselbrecht S. , Sola B.
Nucleic Acids Res.21:750-750(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
tissue: Liver.
tissue: Urinary bladder.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
6.

"Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation."
Yue X. , Favot P. , Dunn T.L. , Cassady A.I. , Hume D.A.
Mol. Cell. Biol.13:3191-3201(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16
7.

"Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line."
van der Geer P. , Hunter T.
Mol. Cell. Biol.10:2991-3002(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-706 AND TYR-807
8.

"Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show differential defects in their ability to induce early response gene transcription."
van der Geer P. , Hunter T.
Mol. Cell. Biol.11:4698-4709(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL PROLIFERATION AND PHOSPHORYLATION OF PIK3R1;INTERACTION WITH PIK3R1;PHOSPHORYLATION AT TYR-706 AND TYR-807;MUTAGENESIS OF TYR-706 AND TYR-807
9.

"Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts."
van der Geer P. , Hunter T.
EMBO J.12:5161-5172(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS CSF1 RECEPTOR;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-697; TYR-706; TYR-721 AND TYR-807;MUTAGENESIS OF LYS-614; TYR-697 AND TYR-721;INTERACTION WITH GRB2
10.

"Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalization."
Myles G.M. , Brandt C.S. , Carlberg K. , Rohrschneider L.R.
Mol. Cell. Biol.14:4843-4854(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS CSF1 RECEPTOR IN CELL PROLIFERATION AND IN ACTIVATION OF AKT1; MAPK1/ERK2; MAPK3/ERK1; STAT3; STAT5A AND STAT5B;INTERACTION WITH CBL; YES1; FYN AND SRC;SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-559 AND TYR-807;UBIQUITINATION;MUTAGENESIS OF TYR-559
11.

"Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling."
Bourette R.P. , Myles G.M. , Choi J.L. , Rohrschneider L.R.
EMBO J.16:5880-5893(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MACROPHAGE PROLIFERATION; MACROPHAGE DIFFERENTIATION; PHOSPHORYLATION OF PLCG2; PHOSPHORYLATION OF PIK3R1 AND PHOSPHORYLATION OF GRB2;CATALYTIC ACTIVITY;INTERACTION WITH PIK3R1; GRB2; PLCG2 AND FYN;MUTAGENESIS OF LYS-614; TYR-697; TYR-721 AND TYR-807
12.

"FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation."
Tamura T. , Mancini A. , Joos H. , Koch A. , Hakim C. , Dumanski J. , Weidner K.M. , Niemann H.
Oncogene18:6488-6495(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THOC5;MUTAGENESIS OF TYR-544; LYS-614; TYR-706; TYR-721 AND TYR-807
13.

"Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors."
Lee A.W. , States D.J.
Mol. Cell. Biol.20:6779-6798(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects."
Dai X.M. , Ryan G.R. , Hapel A.J. , Dominguez M.G. , Russell R.G. , Kapp S. , Sylvestre V. , Stanley E.R.
Blood99:111-120(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
15.

"C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus."
Wilhelmsen K. , Burkhalter S. , van der Geer P.
Oncogene21:1079-1089(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBL;PHOSPHORYLATION AT TYR-974
16.

"A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation."
Rohde C.M. , Schrum J. , Lee A.W.
J. Biol. Chem.279:43448-43461(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-559;PHOSPHORYLATION AT TYR-559;DOMAIN;ENZYME REGULATION
17.

"SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling."
Wang Y. , Keogh R.J. , Hunter M.G. , Mitchell C.A. , Frey R.S. , Javaid K. , Malik A.B. , Schurmans S. , Tridandapani S. , Marsh C.B.
J. Immunol.173:6820-6830(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INPPL1
18.

"Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts."
Sakai H. , Chen Y. , Itokawa T. , Yu K.P. , Zhu M.L. , Insogna K.
Bone39:1290-1301(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
Ghesquiere B. , Van Damme J. , Martens L. , Vandekerckhove J. , Gevaert K.
J. Proteome Res.5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-491
strain: C57BL/6.
tissue: Plasma.
20.

"T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation."
Simoncic P.D. , Bourdeau A. , Lee-Loy A. , Rohrschneider L.R. , Tremblay M.L. , Stanley E.R. , McGlade C.J.
Mol. Cell. Biol.26:4149-4160(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN2
21.

"The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation."
Pakuts B. , Debonneville C. , Liontos L.M. , Loreto M.P. , McGlade C.J.
J. Biol. Chem.282:17953-17963(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SLA2;INTERACTION WITH SLA2 AND CBL;SUBCELLULAR LOCATION;UBIQUITINATION
22.

"c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages."
Takeshita S. , Faccio R. , Chappel J. , Zheng L. , Feng X. , Weber J.D. , Teitelbaum S.L. , Ross F.P.
J. Biol. Chem.282:18980-18990(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-559;PHOSPHORYLATION AT TYR-921
23.

"M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Tyr-559/697/721."
Faccio R. , Takeshita S. , Colaianni G. , Chappel J. , Zallone A. , Teitelbaum S.L. , Ross F.P.
J. Biol. Chem.282:18991-18999(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
24.

"Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-gamma2 and MAP kinases ERK1 and ERK2."
Bourgin-Hierle C. , Gobert-Gosse S. , Therier J. , Grasset M.F. , Mouchiroud G.
Leukemia22:161-169(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SIGNALING PATHWAY
25.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals."
Hiraga T. , Nakamura H.
Int. J. Cancer124:215-222(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN OSTEOCLAST DIFFERENTIATION;ROLE IN DISEASE;ENZYME REGULATION
27.

"c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis."
Paniagua R.T. , Chang A. , Mariano M.M. , Stein E.A. , Wang Q. , Lindstrom T.M. , Sharpe O. , Roscow C. , Ho P.P. , Lee D.M. , Robinson W.H.
Arthritis Res. Ther.12:R32-R32(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN DISEASE
28.

"Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells."
Wei S. , Nandi S. , Chitu V. , Yeung Y.G. , Yu W. , Huang M. , Williams L.T. , Lin H. , Stanley E.R.
J. Leukoc. Biol.88:495-505(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS IL34 AND CSF1 RECEPTOR;FUNCTION IN ACTIVATION OF MAPK1/ERK2 AND MAPK3/ERK1;PHOSPHORYLATION AT TYR-559; TYR-807 AND TYR-721;AUTOPHOSPHORYLATION;TISSUE SPECIFICITY
29.

"Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation."
Lenzo J.C. , Turner A.L. , Cook A.D. , Vlahos R. , Anderson G.P. , Reynolds E.C. , Hamilton J.A.
Immunol. Cell Biol.90:429-440(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
30.

"A CSF-1 receptor phosphotyrosine 559 signaling pathway regulates receptor ubiquitination and tyrosine phosphorylation."
Xiong Y. , Song D. , Cai Y. , Yu W. , Yeung Y.G. , Stanley E.R.
J. Biol. Chem.286:952-960(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
31.

"Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion."
Sampaio N.G. , Yu W. , Cox D. , Wyckoff J. , Condeelis J. , Stanley E.R. , Pixley F.J.
J. Cell Sci.124:2021-2031(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF CELL MOTILITY; CELL SHAPE; ACTIN CYTOSKELETON REORGANIZATION; PHOSPHORYLATION OF AKT1 AND REGULATION OF PHOSPHATIDYLINOSITOL METABOLISM;INTERACTION WITH PIK3R1 AND PLCG2;PHOSPHORYLATION AT TYR-706 AND TYR-721;MUTAGENESIS OF TYR-721
32.

"Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases."
Chen X. , Liu H. , Focia P.J. , Shim A.H. , He X.
Proc. Natl. Acad. Sci. U.S.A.105:18267-18272(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 20-296 IN COMPLEX WITH CSF1;GLYCOSYLATION AT ASN-45 AND ASN-73;SUBUNIT;DISULFIDE BONDS

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