Protein name:
Macrophage colony-stimulating factor 1 (CSF-1;M-CSF;MCSF) ;
Alternative:
Lanimostim ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer or heterodimer; disulfide-linked.
Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
Subcellular Location:
Processed macrophage colony-stimulating factor 1
Secreted
extracellular space
Protein Attributes:
50:
MTAPGAAGRC | PPTTWLGSLL | LLVCLLASRS | ITEEVSEYCS | HMIGSGHLQS |
100:
LQRLIDSQME | TSCQITFEFV | DQEQLKDPVC | YLKKAFLLVQ | DIMEDTMRFR |
150:
DNTPNAIAIV | QLQELSLRLK | SCFTKDYEEH | DKACVRTFYE | TPLQLLEKVK |
200:
NVFNETKNLL | DKDWNIFSKN | CNNSFAECSS | QDVVTKPDCN | CLYPKAIPSS |
250:
DPASVSPHQP | LAPSMAPVAG | LTWEDSEGTE | GSSLLPGEQP | LHTVDPGSAK |
300:
QRPPRSTCQS | FEPPETPVVK | DSTIGGSPQP | RPSVGAFNPG | MEDILDSAMG |
350:
TNWVPEEASG | EASEIPVPQG | TELSPSRPGG | GSMQTEPARP | SNFLSASSPL |
400:
PASAKGQQPA | DVTGTALPRV | GPVRPTGQDW | NHTPQKTDHP | SALLRDPPEP |
450:
GSPRISSLRP | QGLSNPSTLS | AQPQLSRSHS | SGSVLPLGEL | EGRRSTRDRR |
500:
SPAEPEGGPA | SEGAARPLPR | FNSVPLTDTG | HERQSEGSFS | PQLQESVFHL |
550:
LVPSVILVLL | AVGGLLFYRW | RRRSHQEPQR | ADSPLEQPEG | SPLTQDDRQV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human CSF-1
ELISA Kit for Human CSF-1
ELISA Kit for Human CSF-1
Polyclonal Antibody for Human CSF-1
Polyclonal Antibody for Human CSF-1
Polyclonal Antibody for Human CSF-1
Monoclonal Antibody for Human CSF-1
Monoclonal Antibody for Human CSF-1
Monoclonal Antibody for Human CSF-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-489
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Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-489
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-489
tissue :
Kidney .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-13 AND 19-554 (ISOFORM 1);VARIANT SER-489
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Pancreatic carcinoma .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 13-554 (ISOFORM 3);VARIANT SER-489
tissue :
Endometrium .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 33-185 (ISOFORM 1)
tissue :
T lymphoblast .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 33-76
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 35-61
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION (ISOFORM 3)
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING;SUBUNIT;GLYCOSYLATION;SUBCELLULAR LOCATION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING;SUBUNIT;SUBCELLULAR LOCATION;STRUCTURE OF CARBOHYDRATES
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISULFIDE BONDS
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION AND SIGNALING PATHWAYS
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION IN IMMUNITY AND INFLAMMATION;ROLE IN DISEASE
20.
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Wepsic H.T.
,
Myers M.P.
,
Koths K.
,
Jadus M.R.
Int. Immunopharmacol.8:1354-1376(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : REVIEW ON FUNCTION AND SIGNALING PATHWAYS
21.
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Cited for : ROLE IN DISEASE
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Cited for : FUNCTION IN RELEASE OF PROINFLAMMATORY CHEMOKINES
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Cited for : FUNCTION;INTERACTION WITH CSF1R
24.
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Cited for : GLYCOSYLATION AT THR-363 AND THR-365;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
25.
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Cited for : GLYCOSYLATION;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 33-190