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Index > Protein center > CSF1(Gene name) > Human
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  • CSF1 (Gene name),
  • Macrophage colony-stimulating factor 1 (Protein name ),  CSF1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CSF1;
    Protein name:
    Macrophage colony-stimulating factor 1(CSF-1;M-CSF;MCSF);
    Alternative:
    Lanimostim;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer or heterodimer; disulfide-linked.
    Function:
    Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
    Subcellular Location:
    Processed macrophage colony-stimulating factor 1 Secreted extracellular space
    Protein Attributes:
    Sequence length:
    554
    Sequence:
    50:
    MTAPGAAGRC | PPTTWLGSLL | LLVCLLASRS | ITEEVSEYCS | HMIGSGHLQS | 
    100:
    LQRLIDSQME | TSCQITFEFV | DQEQLKDPVC | YLKKAFLLVQ | DIMEDTMRFR | 
    150:
    DNTPNAIAIV | QLQELSLRLK | SCFTKDYEEH | DKACVRTFYE | TPLQLLEKVK | 
    200:
    NVFNETKNLL | DKDWNIFSKN | CNNSFAECSS | QDVVTKPDCN | CLYPKAIPSS | 
    250:
    DPASVSPHQP | LAPSMAPVAG | LTWEDSEGTE | GSSLLPGEQP | LHTVDPGSAK | 
    300:
    QRPPRSTCQS | FEPPETPVVK | DSTIGGSPQP | RPSVGAFNPG | MEDILDSAMG | 
    350:
    TNWVPEEASG | EASEIPVPQG | TELSPSRPGG | GSMQTEPARP | SNFLSASSPL | 
    400:
    PASAKGQQPA | DVTGTALPRV | GPVRPTGQDW | NHTPQKTDHP | SALLRDPPEP | 
    450:
    GSPRISSLRP | QGLSNPSTLS | AQPQLSRSHS | SGSVLPLGEL | EGRRSTRDRR | 
    500:
    SPAEPEGGPA | SEGAARPLPR | FNSVPLTDTG | HERQSEGSFS | PQLQESVFHL | 
    550:
    LVPSVILVLL | AVGGLLFYRW | RRRSHQEPQR | ADSPLEQPEG | SPLTQDDRQV | 
    554:
    ELPV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    MIM:
    UniGene:
    String:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human CSF-1
    Cat.:
    E0090h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human CSF-1
    Cat.:
    E0090m
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human CSF-1
    Cat.:
    E0090r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human CSF-1
    Cat.:
    U0090r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human CSF-1
    Cat.:
    U0090h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CSF-1
    Cat.:
    U0090m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human CSF-1
    Cat.:
    P0090Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CSF-1
    Cat.:
    P0090Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CSF-1
    Cat.:
    P0090Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human CSF-1
    Monoclonal Antibody for Human CSF-1
    Monoclonal Antibody for Human CSF-1
    Protein for Human CSF-1
    Protein for Human CSF-1
    Protein for Human CSF-1

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    Precision
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    Linearity
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    References
    1. 1.
      "Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1)."
      Kawasaki E.S. , Ladner M.B. , Wang A.M. , van Arsdell J.N. , Warren M.K. , Coyne M.Y. , Schweickart V.L. , Lee M.-T. , Wilson K.J. , Boosman A. , Stanley E.R. , Ralph P. , Mark D.F.
      Science230:291-296(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];PROTEIN SEQUENCE OF 33-44 (ISOFORM 3);VARIANT SER-489
      tissue: Pancreatic carcinoma.
      tissue: Urine.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;VARIANT SER-489
      tissue: Trophoblast.
      tissue: Urine.
    3. 3.
      "Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene."
      Cerretti D.P. , Wignall J. , Anderson D. , Tushinski R.J. , Gallis B.M. , Stya M. , Gillis S. , Urdal D.L. , Cosman D.
      Mol. Immunol.25:761-770(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING;MUTAGENESIS OF ISOFORM 3;VARIANT SER-489
      tissue: Pancreatic carcinoma.
    4. 4.
      "Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its in vitro biological activity: molecular cloning and expression of carboxyl-terminal deletion mutants of human M-CSF."
      Takahashi M. , Hirato T. , Takano M. , Nishida T. , Nagamura K. , Kamogashira T. , Nakai S. , Hirai Y.
      Biochem. Biophys. Res. Commun.161:892-901(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS PRO-408 AND SER-489
      tissue: T lymphoblast.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-489
      tissue: Placenta.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-489
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-489
      tissue: Kidney.
    9. 9.
      "Human CSF-1: gene structure and alternative splicing of mRNA precursors."
      Ladner M.B. , Martin G.A. , Noble J.A. , Nikoloff D.M. , Tal R. , Kawasaki E.S. , White T.J.
      EMBO J.6:2693-2698(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-13 AND 19-554 (ISOFORM 1);VARIANT SER-489
      tissue: Pancreatic carcinoma.
    10. 10.
      "Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1."
      Pampfer S. , Tabibzadeh S. , Chuan F.-C. , Pollard J.W.
      Mol. Endocrinol.5:1931-1938(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-554 (ISOFORM 3);VARIANT SER-489
      tissue: Endometrium.
    11. 11.
      "The structure of recombinant human carboxy-terminal-truncated macrophage colony-stimulating factor derived from mammalian cells."
      Yamanishi K. , Yasuda S. , Masui Y. , Nishida T. , Shindo Y. , Takano M. , Ohmoto Y. , Takahashi M. , Adachi M.
      J. Biochem.114:255-262(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-185 (ISOFORM 1)
      tissue: T lymphoblast.
    12. 12.
      "Macrophage colony-stimulating factor purified from normal human urine. Amino-terminal sequence and amino acid composition."
      Sakai N. , Umeda T. , Suzuki H. , Ishimatsu Y. , Shikita M.
      FEBS Lett.222:341-344(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-76
    13. 13.
      "Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis."
      Takahashi M. , Hong Y.M. , Yasuda S. , Takano M. , Kawai K. , Nakai S. , Hirai Y.
      Biochem. Biophys. Res. Commun.152:1401-1409(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-61
    14. 14.
      "Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes."
      Rettenmier C.W. , Roussel M.F. , Ashmun R.A. , Ralph P. , Price K. , Sherr C.J.
      Mol. Cell. Biol.7:2378-2387(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION (ISOFORM 3)
    15. 15.
      "Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs."
      Rettenmier C.W. , Roussel M.F.
      Mol. Cell. Biol.8:5026-5034(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;SUBUNIT;GLYCOSYLATION;SUBCELLULAR LOCATION
    16. 16.
      "Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species."
      Suzu S. , Ohtsuki T. , Yanai N. , Takatsu Z. , Kawashima T. , Takaku F. , Nagata N. , Motoyoshi K.
      J. Biol. Chem.267:4345-4348(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;SUBUNIT;SUBCELLULAR LOCATION;STRUCTURE OF CARBOHYDRATES
    17. 17.
      "Assignment of the inter- and intramolecular disulfide linkages in recombinant human macrophage colony stimulating factor using fast atom bombardment mass spectrometry."
      Glocker M.O. , Arbogast B. , Schreurs J. , Deinzer M.L.
      Biochemistry32:482-488(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    18. 18.
      "CSF-1 regulation of the wandering macrophage: complexity in action."
      Pixley F.J. , Stanley E.R.
      Trends Cell Biol.14:628-638(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION AND SIGNALING PATHWAYS
    19. 19.
      "Colony-stimulating factor-1 in immunity and inflammation."
      Chitu V. , Stanley E.R.
      Curr. Opin. Immunol.18:39-48(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN IMMUNITY AND INFLAMMATION;ROLE IN DISEASE
    20. 20.
      "Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies."
      Douglass T.G. , Driggers L. , Zhang J.G. , Hoa N. , Delgado C. , Williams C.C. , Dan Q. , Sanchez R. , Jeffes E.W. , Wepsic H.T. , Myers M.P. , Koths K. , Jadus M.R.
      Int. Immunopharmacol.8:1354-1376(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION AND SIGNALING PATHWAYS
    21. 21.
      "Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor."
      Patsialou A. , Wyckoff J. , Wang Y. , Goswami S. , Stanley E.R. , Condeelis J.S.
      Cancer Res.69:9498-9506(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN DISEASE
    22. 22.
      "Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood."
      Eda H. , Zhang J. , Keith R.H. , Michener M. , Beidler D.R. , Monahan J.B.
      Cytokine52:215-220(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RELEASE OF PROINFLAMMATORY CHEMOKINES
    23. 23.
      "Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells."
      Wei S. , Nandi S. , Chitu V. , Yeung Y.G. , Yu W. , Huang M. , Williams L.T. , Lin H. , Stanley E.R.
      J. Leukoc. Biol.88:495-505(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CSF1R
    24. 24.
      "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
      Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
      Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-363 AND THR-365;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
    25. 25.
      "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
      Halim A. , Ruetschi U. , Larson G. , Nilsson J.
      J. Proteome Res.12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;IDENTIFICATION BY MASS SPECTROMETRY
    26. 26.
      "Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor."
      Pandit J. , Bohm A. , Jancarik J. , Halenbeck R. , Koths K. , Kim S.H.
      Science258:1358-1362(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 33-190
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