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Index > Protein center > Csf1(Gene name) > Mouse
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  • Csf1 (Gene name),
  • Macrophage colony-stimulating factor 1 (Protein name ),  CSF1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Csf1(Csfm);
    Protein name:
    Macrophage colony-stimulating factor 1(CSF-1;MCSF);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer or heterodimer; disulfide-linked.
    Function:
    Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
    Subcellular Location:
    Processed macrophage colony-stimulating factor 1 Secreted extracellular space
    Protein Attributes:
    Sequence length:
    552
    Sequence:
    50:
    MTARGAAGRC | PSSTWLGSRL | LLVCLLMSRS | IAKEVSEHCS | HMIGNGHLKV | 
    100:
    LQQLIDSQME | TSCQIAFEFV | DQEQLDDPVC | YLKKAFFLVQ | DIIDETMRFK | 
    150:
    DNTPNANATE | RLQELSNNLN | SCFTKDYEEQ | NKACVRTFHE | TPLQLLEKIK | 
    200:
    NFFNETKNLL | EKDWNIFTKN | CNNSFAKCSS | RDVVTKPDCN | CLYPKATPSS | 
    250:
    DPASASPHQP | PAPSMAPLAG | LAWDDSQRTE | GSSLLPSELP | LRIEDPGSAK | 
    300:
    QRPPRSTCQT | LESTEQPNHG | DRLTEDSQPH | PSAGGPVPGV | EDILESSLGT | 
    350:
    NWVLEEASGE | ASEGFLTQEA | KFSPSTPVGG | SIQAETDRPR | ALSASPFPKS | 
    400:
    TEDQKPVDIT | DRPLTEVNPM | RPIGQTQNNT | PEKTDGTSTL | REDHQEPGSP | 
    450:
    HIATPNPQRV | SNSATPVAQL | LLPKSHSWGI | VLPLGELEGK | RSTRDRRSPA | 
    500:
    ELEGGSASEG | AARPVARFNS | IPLTDTGHVE | QHEGSSDPQI | PESVFHLLVP | 
    550:
    GIILVLLTVG | GLLFYKWKWR | SHRDPQTLDS | SVGRPEDSSL | TQDEDRQVEL | 
    552:
    PV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CSF-1
    Cat.:
    E0090h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse CSF-1
    Cat.:
    E0090m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse CSF-1
    Cat.:
    E0090r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse CSF-1
    Cat.:
    U0090r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse CSF-1
    Cat.:
    U0090h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CSF-1
    Cat.:
    U0090m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse CSF-1
    Cat.:
    P0090Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse CSF-1
    Cat.:
    P0090Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse CSF-1
    Cat.:
    P0090Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse CSF-1
    Monoclonal Antibody for Mouse CSF-1
    Monoclonal Antibody for Mouse CSF-1
    Protein for Mouse CSF-1
    Protein for Mouse CSF-1
    Protein for Mouse CSF-1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Nucleotide sequence of a cDNA encoding murine CSF-1 (Macrophage-CSF)."
      Delamarter J.F. , Hession C. , Semon D. , Gough N.M. , Rothenbuhler R. , Mermod J.-J.
      Nucleic Acids Res.15:2389-2390(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "cDNA cloning and expression of murine macrophage colony-stimulating factor from L929 cells."
      Ladner M.B. , Martin G.A. , Noble J.A. , Wittman V.P. , Warren M.K. , McGrogan M. , Stanley E.R.
      Proc. Natl. Acad. Sci. U.S.A.85:6706-6710(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Isolation and characterization of a cDNA clone encoding for rat CSF-1 gene. Post-transcriptional repression occurs in myogenic differentiation."
      Borycki A.G. , Lenormund J. , Guillier M. , Leibovitch S.A.
      Biochim. Biophys. Acta1174:143-152(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Head.
      tissue: Spinal cord.
    5. 5.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Embryonic germ cell.
      tissue: Neural stem cell.
    7. 7.
      "Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA."
      Rajavashisth T.B. , Eng R. , Shadduck R.K. , Waheed A. , Ben-Avram C.M. , Shively J.E. , Lusis A.J.
      Proc. Natl. Acad. Sci. U.S.A.84:1157-1161(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-100
    8. 8.
      "Amino-terminal amino acid sequence of murine colony-stimulating factor 1."
      Ben-Avram C.M. , Shively J.E. , Shadduck R.K. , Waheed A. , Rajavashisth T.B. , Lusis A.J.
      Proc. Natl. Acad. Sci. U.S.A.82:4486-4489(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-57
    9. 9.
      "Cloning and characterization of the murine promoter for the colony-stimulating factor-1-encoding gene."
      Harrington M.A. , Edenberg H.J. , Saxman S.M. , Pedigo L.M. , Daub R. , Broxmeyer H.E.
      Gene102:165-170(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-13
    10. 10.
      "Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat."
      Dobbins D.E. , Sood R. , Hashiramoto A. , Hansen C.T. , Wilder R.L. , Remmers E.F.
      Biochem. Biophys. Res. Commun.294:1114-1120(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SHOWS THAT SEQUENCE DESCRIBED IN PUBMED:8357831 ORIGINATES FROM MOUSE
    11. 11.
      "The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification."
      Van Wesenbeeck L. , Odgren P.R. , MacKay C.A. , D'Angelo M. , Safadi F.F. , Popoff S.N. , Van Hul W. , Marks S.C. Jr.
      Proc. Natl. Acad. Sci. U.S.A.99:14303-14308(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SHOWS THAT SEQUENCE DESCRIBED IN PUBMED:8357831 ORIGINATES FROM MOUSE
    12. 12.
      "The predominant form of secreted colony stimulating factor-1 is a proteoglycan."
      Price L.K.H. , Choi H.U. , Rosenberg L. , Stanley E.R.
      J. Biol. Chem.267:2190-2199(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    13. 13.
      "The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene."
      Yoshida H. , Hayashi S. , Kunisada T. , Ogawa M. , Nishikawa S. , Okamura H. , Sudo T. , Shultz L.D. , Nishikawa S.
      Nature345:442-444(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
    14. 14.
      "Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases."
      Chen X. , Liu H. , Focia P.J. , Shim A.H. , He X.
      Proc. Natl. Acad. Sci. U.S.A.105:18267-18272(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 36-180 IN COMPLEX WITH CSF1R;SUBUNIT;DISULFIDE BONDS
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