CSNK2A1 ELISA Kit for Human(Homo sapiens) | EIAab.comCSNK2A1 ELISA Kit for Human(Homo sapiens)

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CSNK2A1 (Gene name),

Casein kinase II subunit alpha (Protein name ), CSK21_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CSNK2A1(CK2A1);

Protein name:

Casein kinase II subunit alpha(CK II alpha);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with RNPS1.

Function:

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

391

Sequence:

50:

100:

150:

200:

250:

300:

350:

391:

MMSGISSVPT | PSPLGPLAGS | PVIAAANPLG | MPVPAAAGAQ | Q

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.644056

SMR:

P68400

String:

P68400

MIM:

115440

Pfam:

PF00069

STRING:

9606.ENSP00000217244

KEGG:

hsa:1457

Uniprot:

P68400

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ELISA Kit for Human CK II alpha

Cat.:

E10177h

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Manual:

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Packing:

96T

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ELISA Kit for Human CK II alpha

MSDS:

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ELISA Kit for Human CK II alpha

MSDS:

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ELISA Kit for Human CK II alpha

Cat.:

E10177m

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Packing:

96T

ELISA Kit for Human CK II alpha

Cat.:

E10177r

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Packing:

96T

ELISA Kit for Human CK II alpha

MSDS:

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CLIA Kit for Human CK II alpha

Cat.:

U10177m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human CK II alpha

Cat.:

U10177r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human CK II alpha

MSDS:

Please sign in first.

CLIA Kit for Human CK II alpha

MSDS:

Please sign in first.

CLIA Kit for Human CK II alpha

MSDS:

Please sign in first.

CLIA Kit for Human CK II alpha

Cat.:

U10177h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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Polyclonal Antibody for Human CK II alpha

Cat.:

P10177Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human CK II alpha

Monoclonal Antibody for Human CK II alpha

Protein for Human CK II alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning of the human casein kinase II alpha subunit."
Meisner H. , Heller-Harrison R. , Buxton J. , Czech M.P.
Biochemistry28:4072-4076(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II."
Lozeman F.J. , Litchfield D.W. , Piening C. , Takio K. , Walsh K.A. , Krebs E.G.
Biochemistry29:8436-8447(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Structure and sequence of an intronless gene for human casein kinase II-alpha subunit."
Devilat I. , Carvallo P.
FEBS Lett.316:114-118(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
5.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
7.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
tissue: Muscle.
tissue: Uterus.
10.

"Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro."
Bosc D.G. , Slominski E. , Sichler C. , Litchfield D.W.
J. Biol. Chem.270:25872-25878(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-344; THR-360; SER-362 AND SER-370
11.

"A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1."
Keller D.M. , Zeng X. , Wang Y. , Zhang Q.H. , Kapoor M. , Shu H. , Goodman R. , Lozano G. , Zhao Y. , Lu H.
Mol. Cell7:283-292(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SSRP1 AND SUPT16H
12.

"Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells."
Sayed M. , Pelech S. , Wong C. , Marotta A. , Salh B.
Oncogene20:6994-7005(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL CYCLE
13.

"p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex."
Keller D.M. , Lu H.
J. Biol. Chem.277:50206-50213(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SSRP1 AND SUPT16H
14.

"Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8."
Shin S. , Lee Y. , Kim W. , Ko H. , Choi H. , Kim K.
EMBO J.24:3532-3542(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS
15.

"Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation."
Trembley J.H. , Tatsumi S. , Sakashita E. , Loyer P. , Slaughter C.A. , Suzuki H. , Endo H. , Kidd V.J. , Mayeda A.
Mol. Cell. Biol.25:1446-1457(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNPS1
16.

"Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha."
St-Denis N.A. , Derksen D.R. , Litchfield D.W.
Mol. Cell. Biol.29:2068-2081(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL CYCLE
17.

"One-thousand-and-one substrates of protein kinase CK2?"
Meggio F. , Pinna L.A.
FASEB J.17:349-368(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
18.

"Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights."
Niefind K. , Raaf J. , Issinger O.G.
Cell. Mol. Life Sci.66:1800-1816(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON STRUCTURE
19.

"Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival."
St-Denis N.A. , Litchfield D.W.
Cell. Mol. Life Sci.66:1817-1829(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
20.

"Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair."
Filhol O. , Cochet C.
Cell. Mol. Life Sci.66:1830-1839(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
21.

"Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery."
Miyata Y.
Cell. Mol. Life Sci.66:1840-1849(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN REGULATION OF HSP90
22.

"Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer."
Dominguez I. , Sonenshein G.E. , Seldin D.C.
Cell. Mol. Life Sci.66:1850-1857(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN WNT SIGNALING
23.

"Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A."
MacPherson M.R. , Molina P. , Souchelnytskyi S. , Wernstedt C. , Martin-Perez J. , Portillo F. , Cano A.
Mol. Biol. Cell21:244-253(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNAI1
24.

"Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer."
Hung M.S. , Lin Y.C. , Mao J.H. , Kim I.J. , Xu Z. , Yang C.T. , Jablons D.M. , You L.
PLoS ONE5:E11418-E11418(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;INTERACTION WITH PML
25.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA."
Rabellino A. , Carter B. , Konstantinidou G. , Wu S.Y. , Rimessi A. , Byers L.A. , Heymach J.V. , Girard L. , Chiang C.M. , Teruya-Feldstein J. , Scaglioni P.P.
Cancer Res.72:2275-2284(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PML
27.

"Crystallization and preliminary characterization of crystals of human protein kinase CK2."
Niefind K. , Guerra B. , Ermakowa I. , Issinger O.G.
Acta Crystallogr. D56:1680-1684(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 1-337;SUBUNIT
28.

"Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme."
Niefind K. , Guerra B. , Ermakowa I. , Issinger O.G.
EMBO J.20:5320-5331(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 1-337 IN COMPLEX WITH CSNK2B;SUBUNIT
29.

"Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2."
Pechkova E. , Zanotti G. , Nicolini C.
Acta Crystallogr. D59:2133-2139(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-329
30.

"Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit."
Ermakova I. , Boldyreff B. , Issinger O.G. , Niefind K.
J. Mol. Biol.330:925-934(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 2-335

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