Gene name:
Cops2 (Csn2;Trip15) ;
Protein name:
COP9 signalosome complex subunit 2 (SGN2;Signalosome subunit 2) ;
Alternative:
JAB1-containing signalosome subunit 2 ;Alien homolog ;Thyroid receptor-interacting protein 15 (TR-interacting protein 15;TRIP-15) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4, COPS5 COPS6 and COPS7 (COPS7A or COPS7B). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1 (By similarity). Interacts with NIF3L1. Interacts with CUL1 and CUL2.
Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MSDMEDDFMC | DDEEDYDLEY | SEDSNSEPNV | DLENQYYNSK | ALKEDDPKAA |
100:
LSSFQKVLEL | EGEKGEWGFK | ALKQMIKINF | KLTNFPEMMN | RYKQLLTYIR |
150:
SAVTRNYSEK | SINSILDYIS | TSKQMDLLQE | FYETTLEALK | DAKNDRLWFK |
200:
TNTKLGKLYL | EREEYGKLQK | ILRQLHQSCQ | TDDGEDDLKK | GTQLLEIYAL |
250:
EIQMYTAQKN | NKKLKALYEQ | SLHIKSAIPH | PLIMGVIREC | GGKMHLREGE |
300:
FEKAHTDFFE | AFKNYDESGS | PRRTTCLKYL | VLANMLMKSG | INPFDSQEAK |
350:
PYKNDPEILA | MTNLVSAYQN | NDITEFEKIL | KTNHSNIMDD | PFIREHIEEL |
400:
LRNIRTQVLI | KLIKPYTRIH | IPFISKELNI | DVADVESLLV | QCILDNTIHG |
443:
RIDQVNQLLE | LDHQKRGGAR | YTALDKWTNQ | LNSLNQAVVS | KLA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Polyclonal Antibody for Mouse SGN2
Polyclonal Antibody for Mouse SGN2
Polyclonal Antibody for Mouse SGN2
Monoclonal Antibody for Mouse SGN2
Monoclonal Antibody for Mouse SGN2
Monoclonal Antibody for Mouse SGN2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
2.
"The transcriptional landscape of the mammalian genome."
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain :
C57BL/6J .
tissue :
Eye .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-443 (ISOFORM 1)
strain :
Czech II .
tissue :
Mammary tumor .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 4-443 (ISOFORM 1);IDENTIFICATION IN THE CSN COMPLEX
strain :
C57BL/6 .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CUL1 AND CUL2
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NIF3L1
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE