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Index > Protein center > Cops2(Gene name) > Mouse
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  • Cops2 (Gene name),
  • COP9 signalosome complex subunit 2 (Protein name ),  CSN2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Cops2(Csn2;Trip15);
    Protein name:
    COP9 signalosome complex subunit 2(SGN2;Signalosome subunit 2);
    Alternative:
    JAB1-containing signalosome subunit 2;Alien homolog;Thyroid receptor-interacting protein 15(TR-interacting protein 15;TRIP-15);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4, COPS5 COPS6 and COPS7 (COPS7A or COPS7B). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1 (By similarity). Interacts with NIF3L1. Interacts with CUL1 and CUL2.
    Function:
    Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    443
    Sequence:
    50:
    MSDMEDDFMC | DDEEDYDLEY | SEDSNSEPNV | DLENQYYNSK | ALKEDDPKAA | 
    100:
    LSSFQKVLEL | EGEKGEWGFK | ALKQMIKINF | KLTNFPEMMN | RYKQLLTYIR | 
    150:
    SAVTRNYSEK | SINSILDYIS | TSKQMDLLQE | FYETTLEALK | DAKNDRLWFK | 
    200:
    TNTKLGKLYL | EREEYGKLQK | ILRQLHQSCQ | TDDGEDDLKK | GTQLLEIYAL | 
    250:
    EIQMYTAQKN | NKKLKALYEQ | SLHIKSAIPH | PLIMGVIREC | GGKMHLREGE | 
    300:
    FEKAHTDFFE | AFKNYDESGS | PRRTTCLKYL | VLANMLMKSG | INPFDSQEAK | 
    350:
    PYKNDPEILA | MTNLVSAYQN | NDITEFEKIL | KTNHSNIMDD | PFIREHIEEL | 
    400:
    LRNIRTQVLI | KLIKPYTRIH | IPFISKELNI | DVADVESLLV | QCILDNTIHG | 
    443:
    RIDQVNQLLE | LDHQKRGGAR | YTALDKWTNQ | LNSLNQAVVS | KLA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    KEGG:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SGN2
    ELISA Kit for Mouse SGN2
    ELISA Kit for Mouse SGN2
    CLIA Kit for Mouse SGN2
    CLIA Kit for Mouse SGN2
    CLIA Kit for Mouse SGN2
    Polyclonal Antibody for Mouse SGN2
    Polyclonal Antibody for Mouse SGN2
    Polyclonal Antibody for Mouse SGN2
    Monoclonal Antibody for Mouse SGN2
    Monoclonal Antibody for Mouse SGN2
    Monoclonal Antibody for Mouse SGN2
    Protein for Mouse SGN2
    Protein for Mouse SGN2
    Protein for Mouse SGN2

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    Precision
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    Linearity
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    References
    1. 1.
      "Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien."
      Schaefer L. , Beermann M.L. , Miller J.B.
      Genomics56:310-316(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Eye.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-443 (ISOFORM 1)
      strain: Czech II.
      tissue: Mammary tumor.
    4. 4.
      "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex."
      Wei N. , Tsuge T. , Serino G. , Dohmae N. , Takio K. , Matsui M. , Deng X.-W.
      Curr. Biol.8:919-922(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-443 (ISOFORM 1);IDENTIFICATION IN THE CSN COMPLEX
      strain: C57BL/6.
    5. 5.
      "The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1."
      Yang X. , Menon S. , Lykke-Andersen K. , Tsuge T. , Xiao D. , Wang X. , Rodriguez-Suarez R.J. , Zhang H. , Wei N.
      Curr. Biol.12:667-672(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CUL1 AND CUL2
    6. 6.
      "The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2."
      Akiyama H. , Fujisawa N. , Tashiro Y. , Takanabe N. , Sugiyama A. , Tashiro F.
      J. Biol. Chem.278:10752-10762(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NIF3L1
    7. 7.
      "Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death."
      Lykke-Andersen K. , Schaefer L. , Menon S. , Deng X.-W. , Miller J.B. , Wei N.
      Mol. Cell. Biol.23:6790-6797(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
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