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Index > Protein center > COPS3(Gene name) > Human
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  • COPS3 (Gene name),
  • COP9 signalosome complex subunit 3 (Protein name ),  CSN3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    COPS3(CSN3);
    Protein name:
    COP9 signalosome complex subunit 3(SGN3;Signalosome subunit 3);
    Alternative:
    JAB1-containing signalosome subunit 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4 and COPS8. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG.
    Function:
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    423
    Sequence:
    50:
    MASALEQFVN | SVRQLSAQGQ | MTQLCELINK | SGELLAKNLS | HLDTVLGALD | 
    100:
    VQEHSLGVLA | VLFVKFSMPS | VPDFETLFSQ | VQLFISTCNG | EHIRYATDTF | 
    150:
    AGLCHQLTNA | LVERKQPLRG | IGILKQAIDK | MQMNTNQLTS | IHADLCQLCL | 
    200:
    LAKCFKPALP | YLDVDMMDIC | KENGAYDAKH | FLCYYYYGGM | IYTGLKNFER | 
    250:
    ALYFYEQAIT | TPAMAVSHIM | LESYKKYILV | SLILLGKVQQ | LPKYTSQIVG | 
    300:
    RFIKPLSNAY | HELAQVYSTN | NPSELRNLVN | KHSETFTRDN | NMGLVKQCLS | 
    350:
    SLYKKNIQRL | TKTFLTLSLQ | DMASRVQLSG | PQEAEKYVLH | MIEDGEIFAS | 
    400:
    INQKDGMVSF | HDNPEKYNNP | AMLHNIDQEM | LKCIELDERL | KAMDQEITVN | 
    423:
    PQFVQKSMGS | QEDDSGNKPS | SYS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    String:
    UniGene:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human SGN3
    ELISA Kit for Human SGN3
    ELISA Kit for Human SGN3
    ELISA Kit for Human SGN3
    ELISA Kit for Human SGN3
    CLIA Kit for Human SGN3
    CLIA Kit for Human SGN3
    CLIA Kit for Human SGN3
    CLIA Kit for Human SGN3
    CLIA Kit for Human SGN3
    Polyclonal Antibody for Human SGN3
    Polyclonal Antibody for Human SGN3
    Polyclonal Antibody for Human SGN3
    Polyclonal Antibody for Human SGN3
    Polyclonal Antibody for Human SGN3
    Monoclonal Antibody for Human SGN3
    Monoclonal Antibody for Human SGN3
    Monoclonal Antibody for Human SGN3
    Monoclonal Antibody for Human SGN3
    Monoclonal Antibody for Human SGN3
    Protein for Human SGN3
    Protein for Human SGN3
    Protein for Human SGN3
    Protein for Human SGN3
    Protein for Human SGN3

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    References
    1. 1.
      "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits."
      Seeger M. , Kraft R. , Ferrell K. , Bech-Otschir D. , Dumdey R. , Schade R. , Gordon C. , Naumann M. , Dubiel W.
      FASEB J.12:469-478(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;FUNCTION;SUBCELLULAR LOCATION
      tissue: Cervix carcinoma.
    2. 2.
      "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the Smith-Magenis syndrome critical region in 17p11.2."
      Potocki L. , Chen K.-S. , Lupski J.R.
      Genomics57:180-182(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Brain.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Hippocampus.
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    6. 7.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-13 (ISOFORM 1)
      tissue: Platelet.
    7. 8.
      Bienvenut W.V. , Quadroni M.
      Submitted (2005-10) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-13; 31-37; 244-251 AND 313-336 (ISOFORM 1);CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Cervix carcinoma.
      tissue: Platelet.
    8. 9.
      "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system."
      Bech-Otschir D. , Kraft R. , Huang X. , Henklein P. , Kapelari B. , Pollmann C. , Dubiel W.
      EMBO J.20:1630-1639(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 10.
      "CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation."
      Hong X. , Xu L.-G. , Li X. , Zhai Z. , Shu H.-B.
      FEBS Lett.499:133-136(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKBKG
    10. 11.
      "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome."
      Lyapina S. , Cope G. , Shevchenko A. , Serino G. , Tsuge T. , Zhou C. , Wolf D.A. , Wei N. , Shevchenko A. , Deshaies R.J.
      Science292:1382-1385(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;COMPOSITION OF THE CSN COMPLEX
    11. 12.
      "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome."
      Hoareau Alves K. , Bochard V. , Rety S. , Jalinot P.
      FEBS Lett.527:15-21(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF3S6
    12. 13.
      "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage."
      Groisman R. , Polanowska J. , Kuraoka I. , Sawada J. , Saijo M. , Drapkin R. , Kisselev A.F. , Tanaka K. , Nakatani Y.
      Cell113:357-367(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 14.
      "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome."
      Uhle S. , Medalia O. , Waldron R. , Dumdey R. , Henklein P. , Bech-Otschir D. , Huang X. , Berse M. , Sperling J. , Schade R. , Dubiel W.
      EMBO J.22:1302-1312(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CK2 AND PKD
    14. 15.
      "Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation."
      Henriksen J. , Aagesen T.H. , Maelandsmo G.M. , Lothe R.A. , Myklebost O. , Forus A.
      Oncogene22:5358-5361(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEREXPRESSION IN OSTEOSARCOMA
    15. 16.
      "Amplification and overexpression of genes in 17p11.2 approximately p12 in osteosarcoma."
      Van Dartel M. , Hulsebos T.J.M.
      Cancer Genet. Cytogenet.153:77-80(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEREXPRESSION IN OSTEOSARCOMA
    16. 17.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    17. 18.
      "Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry."
      Fang L. , Wang X. , Yamoah K. , Chen P.L. , Pan Z.Q. , Huang L.
      J. Proteome Res.7:4914-4925(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CSN COMPLEX;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;PHOSPHORYLATION AT SER-423
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410 AND SER-423;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 20.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 21.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 23.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 24.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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