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Index > Protein center > CTC1(Gene name) > Human
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  • CTC1 (Gene name),
  • CST complex subunit CTC1 (Protein name ),  CTC1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CTC1(C17orf68);
    Protein name:
    CST complex subunit CTC1;
    Alternative:
    HBV DNAPTP1-transactivated protein B;Conserved telomere maintenance component 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1/OBFC1. Interacts with STN1/OBFC1; the interaction is direct.
    Function:
    Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
    Subcellular Location:
    Nucleus Chromosome telomere A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
    Protein Attributes:
    Sequence length:
    1217
    Sequence:
    50:
    MAAGRAQVPS | SEQAWLEDAQ | VFIQKTLCPA | VKEPNVQLTP | LVIDCVKTVW | 
    100:
    LSQGRNQGST | LPLSYSFVSV | QDLKTHQRLP | CCSHLSWSSS | AYQAWAQEAG | 
    150:
    PNGNPLPREQ | LLLLGTLTDL | SADLEQECRN | GSLYVRDNTG | VLSCELIDLD | 
    200:
    LSWLGHLFLF | PRWSYLPPAR | WNSSGEGHLE | LWDAPVPVFP | LTISPGPVTP | 
    250:
    IPVLYPESAS | CLLRLRNKLR | GVQRNLAGSL | VRLSALVKSK | QKAYFILSLG | 
    300:
    RSHPAVTHVS | IIVQVPAQLV | WHRALRPGTA | YVLTELRVSK | IRGQRQHVWM | 
    350:
    TSQSSRLLLL | KPECVQELEL | ELEGPLLEAD | PKPLPMPSNS | EDKKDPESLV | 
    400:
    RYSRLLSYSG | AVTGVLNEPA | GLYELDGQLG | LCLAYQQFRG | LRRVMRPGVC | 
    450:
    LQLQDVHLLQ | SVGGGTRRPV | LAPCLRGAVL | LQSFSRQKPG | AHSSRQAYGA | 
    500:
    SLYEQLVWER | QLGLPLYLWA | TKALEELACK | LCPHVLRHHQ | FLQHSSPGSP | 
    550:
    SLGLQLLAPT | LDLLAPPGSP | VRNAHNEILE | EPHHCPLQKY | TRLQTPSSFP | 
    600:
    TLATLKEEGQ | RKAWASFDPK | ALLPLPEASY | LPSCQLNRRL | AWSWLCLLPS | 
    650:
    AFCPAQVLLG | VLVASSHKGC | LQLRDQSGSL | PCLLLAKHSQ | PLSDPRLIGC | 
    700:
    LVRAERFQLI | VERDVRSSFP | SWKELSMPGF | IQKQQARVYV | QFFLADALIL | 
    750:
    PVPRPCLHSA | TPSTPQTDPT | GPEGPHLGQS | RLFLLCHKEA | LMKRNFCVPP | 
    800:
    GASPEVPKPA | LSFYVLGSWL | GGTQRKEGTG | WGLPEPQGND | DNDQKVHLIF | 
    850:
    FGSSVRWFEF | LHPGQVYRLI | APGPATPMLF | EKDGSSCISR | RPLELAGCAS | 
    900:
    CLTVQDNWTL | ELESSQDIQD | VLDANKSLPE | SSLTDLLSDN | FTDSLVSFSA | 
    950:
    EILSRTLCEP | LVASLWMKLG | NTGAMRRCVK | LTVALETAEC | EFPPHLDVYI | 
    1000:
    EDPHLPPSLG | LLPGARVHFS | QLEKRVSRSH | NVYCCFRSST | YVQVLSFPPE | 
    1050:
    TTISIPLPHI | YLAELLQGGQ | SPFQATASCH | IVSVFSLQLF | WVCAYCTSIC | 
    1100:
    RQGKCTRLGS | TCPTQTAISQ | AIIRLLVEDG | TAEAVVTCRN | HHVAAALGLC | 
    1150:
    PREWASLLDF | VQVPGRVVLQ | FAGPGAQLES | SARVDEPMTM | FLWTLCTSPS | 
    1200:
    VLRPIVLSFE | LERKPSKIVP | LEPPRLQRFQ | CGELPFLTHV | NPRLRLSCLS | 
    1217:
    IRESEYSSSL | GILASSC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    MIM:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human CST complex subunit CTC1
    ELISA Kit for Human CST complex subunit CTC1
    CLIA Kit for Human CST complex subunit CTC1
    CLIA Kit for Human CST complex subunit CTC1
    Polyclonal Antibody for Human CST complex subunit CTC1
    Polyclonal Antibody for Human CST complex subunit CTC1
    Monoclonal Antibody for Human CST complex subunit CTC1
    Monoclonal Antibody for Human CST complex subunit CTC1
    Protein for Human CST complex subunit CTC1
    Protein for Human CST complex subunit CTC1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      Lun Y.Z. , Cheng J. , Guo J. , Zhang L.Y. , Zhao B.C.
      Submitted (2006-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT VAL-1005
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT VAL-1005
      tissue: Skeletal muscle.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-1005
      tissue: Corpus callosum.
      tissue: Kidney epithelium.
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-1005
      tissue: Lung carcinoma.
      tissue: Uterine adenocarcinoma.
    5. 6.
      "RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway."
      Miyake Y. , Nakamura M. , Nabetani A. , Shimamura S. , Tamura M. , Yonehara S. , Saito M. , Ishikawa F.
      Mol. Cell36:193-206(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE CST COMPLEX;SUBCELLULAR LOCATION
    6. 7.
      "Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes."
      Surovtseva Y.V. , Churikov D. , Boltz K.A. , Song X. , Lamb J.C. , Warrington R. , Leehy K. , Heacock M. , Price C.M. , Shippen D.E.
      Mol. Cell36:207-218(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 8.
      "Mutations in CTC1, encoding the CTS telomere maintenance complex component 1, cause cerebroretinal microangiopathy with calcifications and cysts."
      Polvi A. , Linnankivi T. , Kivela T. , Herva R. , Keating J.P. , Makitie O. , Pareyson D. , Vainionpaa L. , Lahtinen J. , Hovatta I. , Pihko H. , Lehesjoki A.E.
      Am. J. Hum. Genet.90:540-549(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CRMCC VAL-227; GLY-665; GLY-975; CYS-985 DEL; HIS-1142 AND 1196-LEU--ARG-1202 DEL
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