Protein name:
CST complex subunit CTC1 ;
Alternative:
Conserved telomere maintenance component 1 ;Alpha-accessory factor of 132 kDa (AAF-132;AAF132) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the CST complex, composed of TEN1, CTC1 and STN1/OBFC1. Interacts with STN1/OBFC1; the interaction is direct.
Function:
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
Subcellular Location:
Nucleus
Chromosome
telomere
A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
Protein Attributes:
50:
MAACRAQPPT | SEQAWLEAAQ | TFIQETLCPA | GKEVDKELTR | SVIACVKETW |
100:
LSQGENQDLT | LPFSYSFVSV | QSLKTHQRLP | CCSHLSWSQS | AYQAWTRGGR |
150:
PGDGVLPREQ | LILLGTLVDL | LGDSEQECRS | GSLYVRDNTG | TLDCELIDLD |
200:
LSWLGHLFLF | PSWSYLPSAK | RNSLGEGHLE | LWGTPVPVFP | LTVSPGPLIP |
250:
IPVLYPEKAS | HLLRYRKKSS | IKEINLAGKL | VHLSALIITQ | NKRYFIMTLG |
300:
ELAQAGSQVS | IIVQIPAQMV | WHRVLRPGRA | YVLTKLQVTK | TRIHLSCIWT |
350:
TIPSSTLKPL | RPGYVQELEL | DLEFSKADLK | PPPQPTSSKD | SRGQEGLVRA |
400:
SKVLHYLGTV | TAVLHESAGL | YILDGQLILC | LAYQKIHGLR | RVIRPGVCLE |
450:
LRDVHLLQAV | GGATTKPVLA | LCLHGTVRLQ | GFSCLKPLTL | PSSKVYGASL |
500:
YEQLVWKCQL | GLPLYLWAAK | TLEDLIYKLC | PHVLRCHQFL | KQPSPGKPSL |
550:
GLQLLAPSWD | VLIPPGSPMR | HAYSEILEEP | HNCPLQKYTP | LQTPYSFPTM |
600:
LALAEEGQHR | AWATFDPKAM | LPLPEASHLT | SCQLNRHLAW | SWVCLPSCVF |
650:
QPAQVLLGVL | VASSRKGCLE | LRDLRGSLPC | IPLTESSQPL | IDPNLVGCLV |
700:
RVEKFQLVVE | REVRSSFPSW | EEMGMARFIQ | KKQARVYVQF | YLADALILPV |
750:
PRPTFGSEPS | QTASSCPEGP | HLGQSRLFLL | SHKEALMKRN | FCLLPGDSSQ |
800:
PAKPTLSFHV | SGTWLCGTQR | KEGSGWSPPE | SLAVESKDQK | VFLIFLGSSV |
850:
RWFPFLYPNQ | VYRLVASGPS | QTPVFETEGS | AGTSRRPLEL | ADCGSCLTVQ |
900:
EEWTLELGSS | QDIPNVLEVP | RTLPESSLAQ | LLGDNSPDSL | VSFSAEILSR |
950:
ILCEPPLALR | RMKPGNAGAI | KTGVKLTVAL | EMDDCEYPPH | LDIYIEDPQL |
1000:
PPQIGLLPGA | RVHFSQLEKR | ISRSNIVYCC | FRSSTSVQVL | SFPPETKASA |
1050:
PLPHIYLAEL | LQGDRPPFQA | TTSCHIVYVL | SLQILWVCAH | CTSICPQGKC |
1100:
SRRDPSCPSQ | RAVSQANIRL | LVEDGTAEAT | VICRNHLVAR | ALGLSPSEWS |
1150:
SILEHARGPG | RVALQFTGLG | GQTESASKTH | EPLTLLLRTL | CTSPFVLRPV |
1200:
KLSFALERRP | TDISPREPSR | LQQFQCGELP | LLTRVNPRLR | LVCLSLQEPE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse CST complex subunit CTC1
ELISA Kit for Mouse CST complex subunit CTC1
CLIA Kit for Mouse CST complex subunit CTC1
CLIA Kit for Mouse CST complex subunit CTC1
Polyclonal Antibody for Mouse CST complex subunit CTC1
Polyclonal Antibody for Mouse CST complex subunit CTC1
Monoclonal Antibody for Mouse CST complex subunit CTC1
Monoclonal Antibody for Mouse CST complex subunit CTC1
Protein for Mouse CST complex subunit CTC1
Protein for Mouse CST complex subunit CTC1
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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Linearity
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References
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"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
strain :
C57BL/6J .
tissue :
Brain cortex .
tissue :
Cerebellum .
tissue :
Lung .
tissue :
Placenta .
2.
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more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 244-1211 (ISOFORM 2)
strain :
C57BL/6 .
strain :
FVB/N .
tissue :
Brain .
tissue :
Kidney .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 98-108; 110-127; 561-568; 814-832; 962-968; 1090-1106; 1111-1137 AND 1159-1165;SUBCELLULAR LOCATION;DNA-BINDING;INTERACTION WITH OBFC1
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE CST COMPLEX;SUBCELLULAR LOCATION