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Index > Protein center > Ctc1(Gene name) > Mouse
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  • Ctc1 (Gene name),
  • CST complex subunit CTC1 (Protein name ),  CTC1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Ctc1;
    Protein name:
    CST complex subunit CTC1;
    Alternative:
    Conserved telomere maintenance component 1;Alpha-accessory factor of 132 kDa(AAF-132;AAF132);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the CST complex, composed of TEN1, CTC1 and STN1/OBFC1. Interacts with STN1/OBFC1; the interaction is direct.
    Function:
    Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
    Subcellular Location:
    Nucleus Chromosome telomere A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
    Protein Attributes:
    Sequence length:
    1212
    Sequence:
    50:
    MAACRAQPPT | SEQAWLEAAQ | TFIQETLCPA | GKEVDKELTR | SVIACVKETW | 
    100:
    LSQGENQDLT | LPFSYSFVSV | QSLKTHQRLP | CCSHLSWSQS | AYQAWTRGGR | 
    150:
    PGDGVLPREQ | LILLGTLVDL | LGDSEQECRS | GSLYVRDNTG | TLDCELIDLD | 
    200:
    LSWLGHLFLF | PSWSYLPSAK | RNSLGEGHLE | LWGTPVPVFP | LTVSPGPLIP | 
    250:
    IPVLYPEKAS | HLLRYRKKSS | IKEINLAGKL | VHLSALIITQ | NKRYFIMTLG | 
    300:
    ELAQAGSQVS | IIVQIPAQMV | WHRVLRPGRA | YVLTKLQVTK | TRIHLSCIWT | 
    350:
    TIPSSTLKPL | RPGYVQELEL | DLEFSKADLK | PPPQPTSSKD | SRGQEGLVRA | 
    400:
    SKVLHYLGTV | TAVLHESAGL | YILDGQLILC | LAYQKIHGLR | RVIRPGVCLE | 
    450:
    LRDVHLLQAV | GGATTKPVLA | LCLHGTVRLQ | GFSCLKPLTL | PSSKVYGASL | 
    500:
    YEQLVWKCQL | GLPLYLWAAK | TLEDLIYKLC | PHVLRCHQFL | KQPSPGKPSL | 
    550:
    GLQLLAPSWD | VLIPPGSPMR | HAYSEILEEP | HNCPLQKYTP | LQTPYSFPTM | 
    600:
    LALAEEGQHR | AWATFDPKAM | LPLPEASHLT | SCQLNRHLAW | SWVCLPSCVF | 
    650:
    QPAQVLLGVL | VASSRKGCLE | LRDLRGSLPC | IPLTESSQPL | IDPNLVGCLV | 
    700:
    RVEKFQLVVE | REVRSSFPSW | EEMGMARFIQ | KKQARVYVQF | YLADALILPV | 
    750:
    PRPTFGSEPS | QTASSCPEGP | HLGQSRLFLL | SHKEALMKRN | FCLLPGDSSQ | 
    800:
    PAKPTLSFHV | SGTWLCGTQR | KEGSGWSPPE | SLAVESKDQK | VFLIFLGSSV | 
    850:
    RWFPFLYPNQ | VYRLVASGPS | QTPVFETEGS | AGTSRRPLEL | ADCGSCLTVQ | 
    900:
    EEWTLELGSS | QDIPNVLEVP | RTLPESSLAQ | LLGDNSPDSL | VSFSAEILSR | 
    950:
    ILCEPPLALR | RMKPGNAGAI | KTGVKLTVAL | EMDDCEYPPH | LDIYIEDPQL | 
    1000:
    PPQIGLLPGA | RVHFSQLEKR | ISRSNIVYCC | FRSSTSVQVL | SFPPETKASA | 
    1050:
    PLPHIYLAEL | LQGDRPPFQA | TTSCHIVYVL | SLQILWVCAH | CTSICPQGKC | 
    1100:
    SRRDPSCPSQ | RAVSQANIRL | LVEDGTAEAT | VICRNHLVAR | ALGLSPSEWS | 
    1150:
    SILEHARGPG | RVALQFTGLG | GQTESASKTH | EPLTLLLRTL | CTSPFVLRPV | 
    1200:
    KLSFALERRP | TDISPREPSR | LQQFQCGELP | LLTRVNPRLR | LVCLSLQEPE | 
    1212:
    LPNPPQASAA | SS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CST complex subunit CTC1
    ELISA Kit for Mouse CST complex subunit CTC1
    CLIA Kit for Mouse CST complex subunit CTC1
    CLIA Kit for Mouse CST complex subunit CTC1
    Polyclonal Antibody for Mouse CST complex subunit CTC1
    Polyclonal Antibody for Mouse CST complex subunit CTC1
    Monoclonal Antibody for Mouse CST complex subunit CTC1
    Monoclonal Antibody for Mouse CST complex subunit CTC1
    Protein for Mouse CST complex subunit CTC1
    Protein for Mouse CST complex subunit CTC1

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
      strain: C57BL/6J.
      tissue: Brain cortex.
      tissue: Cerebellum.
      tissue: Lung.
      tissue: Placenta.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 244-1211 (ISOFORM 2)
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Brain.
      tissue: Kidney.
    4. 4.
      "A DNA polymerase-{alpha}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells."
      Casteel D.E. , Zhuang S. , Zeng Y. , Perrino F.W. , Boss G.R. , Goulian M. , Pilz R.B.
      J. Biol. Chem.284:5807-5818(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 98-108; 110-127; 561-568; 814-832; 962-968; 1090-1106; 1111-1137 AND 1159-1165;SUBCELLULAR LOCATION;DNA-BINDING;INTERACTION WITH OBFC1
    5. 5.
      "RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway."
      Miyake Y. , Nakamura M. , Nabetani A. , Shimamura S. , Tamura M. , Yonehara S. , Saito M. , Ishikawa F.
      Mol. Cell36:193-206(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE CST COMPLEX;SUBCELLULAR LOCATION
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