CTDSP1 ELISA Kit for Human(Homo sapiens) | EIAab.comCTDSP1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CTDSP1(Gene name) > Human

CTDSP1 (Gene name),

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (Protein name ), CTDS1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CTDSP1(NIF3;NLIIF;SCP1);

Protein name:

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1;

Alternative:

Small C-terminal domain phosphatase 1(SCP1;Small CTD phosphatase 1);Nuclear LIM interactor-interacting factor 3(NLI-IF;NLI-interacting factor 3);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer (By similarity). Interacts with GTF2F1. Interacts with REST.

Function:

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Subcellular Location:

Nucleus Colocalizes with RNA polymerase II.

Protein Attributes:

Sequence length:

261

Sequence:

50:

100:

150:

200:

250:

261:

YSVLRQPRPG | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF03031

String:

Q9GZU7

UniGene:

Hs.444468

KEGG:

hsa:58190

SMR:

Q9GZU7

STRING:

9606.ENSP00000273062

MIM:

605323

Uniprot:

Q9GZU7

FOR

ELISA Kit for Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

CLIA Kit for Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Polyclonal Antibody for Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Monoclonal Antibody for Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Protein for Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35."
Marquet S. , Lepage P. , Hudson T.J. , Musser J.M. , Schurr E.
Mamm. Genome11:755-762(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
2.

"A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5."
Yeo M. , Lin P.S. , Dahmus M.E. , Gill G.N.
J. Biol. Chem.278:26078-26085(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 50-260 (ISOFORM 2);FUNCTION;SUBCELLULAR LOCATION;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;INTERACTION WITH GTF2F1;MUTAGENESIS OF ASP-96 AND ASP-98
3.

"Full-length cDNA libraries and normalization."
Li W.B. , Gruber C. , Jessee J. , Polayes D.
Submitted (2003-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Placenta.
4.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lymph.
6.

"Small CTD phosphatases function in silencing neuronal gene expression."
Yeo M. , Lee S.-K. , Lee B. , Ruiz E.C. , Pfaff S.L. , Gill G.N.
Science307:596-600(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH REST
7.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.

"Structure and mechanism of RNA polymerase II CTD phosphatases."
Kamenski T. , Heilmeier S. , Meinhart A. , Cramer P.
Mol. Cell15:399-407(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 77-261 IN COMPLEX WITH MAGNESIUM AND INHIBITOR
9.

"Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1."
Zhang Y. , Kim Y. , Genoud N. , Gao J. , Kelly J.W. , Pfaff S.L. , Gill G.N. , Dixon J.E. , Noel J.P.
Mol. Cell24:759-770(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 77-256 OF MUTANT ASN-96 IN COMPLEX WITH SUBSTRATE PEPTIDES;SUBSTRATE SPECIFICITY

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