CTDSP2 ELISA Kit for Human(Homo sapiens) | EIAab.comCTDSP2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CTDSP2(Gene name) > Human

CTDSP2 (Gene name),

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (Protein name ), CTDS2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CTDSP2(NIF2;OS4;SCP2);

Protein name:

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2;

Alternative:

Protein OS-4;Nuclear LIM interactor-interacting factor 2(NLI-interacting factor 2);Small CTD phosphatase 2(SCP2);Small C-terminal domain phosphatase 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer (By similarity). Interacts with REST.

Function:

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

271

Sequence:

50:

100:

150:

200:

250:

271:

IFEELSGAED | VYTSLGQLRA | P

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

608711

Pfam:

PF03031

UniGene:

Hs.524530

KEGG:

hsa:10106

String:

O14595

SMR:

O14595

STRING:

9606.ENSP00000381148

Uniprot:

O14595

FOR

ELISA Kit for Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

CLIA Kit for Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Polyclonal Antibody for Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Monoclonal Antibody for Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Protein for Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas."
Su Y.A. , Lee M.M. , Hutter C.M. , Meltzer P.S.
Oncogene15:1289-1294(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5."
Yeo M. , Lin P.S. , Dahmus M.E. , Gill G.N.
J. Biol. Chem.278:26078-26085(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
3.

Morikane K. , Hollingsworth M.A.
Submitted (1997-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Fetal pancreas.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Leukocyte.
7.

"Small CTD phosphatases function in silencing neuronal gene expression."
Yeo M. , Lee S.-K. , Lee B. , Ruiz E.C. , Pfaff S.L. , Gill G.N.
Science307:596-600(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH REST
8.

"Structural genomics of protein phosphatases."
Almo S.C. , Bonanno J.B. , Sauder J.M. , Emtage S. , Dilorenzo T.P. , Malashkevich V. , Wasserman S.R. , Swaminathan S. , Eswaramoorthy S. , Agarwal R. , Kumaran D. , Madegowda M. , Ragumani S. , Patskovsky Y. , Alvarado J. , Ramagopal U.A. , Faber-Barata J. , Chance M.R. , more...
J. Struct. Funct. Genomics8:121-140(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 87-271 IN COMPLEX WITH MAGNESIUM

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