CTLA4 ELISA Kit for Human(Homo sapiens) | EIAab.comCTLA4 ELISA Kit for Human(Homo sapiens)

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CTLA4 (Gene name),

Cytotoxic T-lymphocyte protein 4 (Protein name ), CTLA4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CTLA4(CD152);

Protein name:

Cytotoxic T-lymphocyte protein 4;

Alternative:

Cytotoxic T-lymphocyte-associated antigen 4(CTLA-4);

CD:

CD152;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Binds to CD80/B7-1 and CD86/B7.2.

Function:

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.

Protein Attributes:

Sequence length:

223

Sequence:

50:

100:

150:

200:

223:

YVKMPPTEPE | CEKQFQPYFI | PIN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07686

SMR:

P16410

KEGG:

hsa:1493

MIM:

109100

UniGene:

Hs.247824

String:

P16410

STRING:

9606.ENSP00000303939

Uniprot:

P16410

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ELISA Kit for Human Cytotoxic T-lymphocyte protein 4

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E1230h

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96T

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ELISA Kit for Human Cytotoxic T-lymphocyte protein 4

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ELISA Kit for Human Cytotoxic T-lymphocyte protein 4

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E1230p

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96T

ELISA Kit for Human Cytotoxic T-lymphocyte protein 4

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ELISA Kit for Human Cytotoxic T-lymphocyte protein 4

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E1230m

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96T

CLIA Kit for Human Cytotoxic T-lymphocyte protein 4

Cat.:

U1230m

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96T

CLIA Kit for Human Cytotoxic T-lymphocyte protein 4

Cat.:

U1230h

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96T

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CLIA Kit for Human Cytotoxic T-lymphocyte protein 4

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CLIA Kit for Human Cytotoxic T-lymphocyte protein 4

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U1230d

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96T

CLIA Kit for Human Cytotoxic T-lymphocyte protein 4

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U1230p

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96T

Polyclonal Antibody for Human Cytotoxic T-lymphocyte protein 4

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P1230Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Cytotoxic T-lymphocyte protein 4

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P1230Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Cytotoxic T-lymphocyte protein 4

Monoclonal Antibody for Human Cytotoxic T-lymphocyte protein 4

Protein for Human Cytotoxic T-lymphocyte protein 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location."
Harper K. , Balzano C. , Rouvier E. , Mattei M.-G. , Luciani M.-F. , Golstein P.
J. Immunol.147:1037-1044(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);TISSUE SPECIFICITY;ALTERNATIVE SPLICING;VARIANT ALA-17
2.

"Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches."
Ling V. , Wu P.W. , Finnerty H.F. , Agostino M.J. , Graham J.R. , Chen S. , Jussiff J.M. , Fisk G.J. , Miller C.P. , Collins M.
Genomics78:155-168(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis."
Gu M. , Kakoulidou M. , Giscombe R. , Pirskanen R. , Lefvert A.K. , Klareskog L. , Wang X.
Clin. Immunol.128:374-381(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);VARIANT ALA-17;ALTERNATIVE SPLICING
4.

"Full length sequence of hCTLA4 cDNA."
Wu P.W. , Ling V.
Submitted (2001-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

NIEHS SNPs program
Submitted (2006-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
8.

"Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains."
Dariavach P. , Mattei M.-G. , Golstein P. , Lefranc M.-P.
Eur. J. Immunol.18:1901-1905(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-223
tissue: Lymphocyte.
9.

Oaks M.K.
Submitted (1997-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-223 (ISOFORM 5)
tissue: Lymph node.
10.

"Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders."
Ling V. , Wu P.W. , Finnerty H.F. , Sharpe A.H. , Gray G.S. , Collins M.
Genomics60:341-355(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 140-223;TISSUE SPECIFICITY
11.

"CTLA-4 is a second receptor for the B cell activation antigen B7."
Linsley P.S. , Brady W. , Urnes M. , Griosmaire L.S. , Damle N.K. , Ledbetter J.A.
J. Exp. Med.174:561-569(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2."
Shiratori T. , Miyatake S. , Ohno H. , Nakaseko C. , Isono K. , Bonifacino J.S. , Saito T.
Immunity6:583-589(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-201
13.

"Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4."
Schneider H. , Schwartzberg P.L. , Rudd C.E.
Biochem. Biophys. Res. Commun.252:14-19(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-201
14.

"Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4."
Chikuma S. , Murakami M. , Tanaka K. , Uede T.
J. Cell. Biochem.78:241-250(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-201 BY JAK2
15.

"Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease."
Ueda H. , Howson J.M. , Esposito L. , Heward J. , Snook H. , Chamberlain G. , Rainbow D.B. , Hunter K.M. , Smith A.N. , Di Genova G. , Herr M.H. , Dahlman I. , Payne F. , Smyth D. , Lowe C. , Twells R.C. , Howlett S. , Healy B. , more...
Nature423:506-511(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM
16.

"Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation."
Darlington P.J. , Kirchhof M.G. , Criado G. , Sondhi J. , Madrenas J.
J. Immunol.175:996-1004(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-113 AND ASN-145
17.

"A molecular perspective of CTLA-4 function."
Teft W.A. , Kirchhof M.G. , Madrenas J.
Annu. Rev. Immunol.24:65-97(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
18.

"CTLA-4 trafficking and surface expression."
Valk E. , Rudd C.E. , Schneider H.
Trends Immunol.29:272-279(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
19.

"The clinical utility of inhibiting CD28-mediated costimulation."
Linsley P.S. , Nadler S.G.
Immunol. Rev.229:307-321(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHARMACEUTICAL
20.

"Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28."
Metzler W.J. , Bajorath J. , Fenderson W. , Shaw S.Y. , Constantine K.L. , Naemura J. , Leytze G. , Peach R.J. , Lavoie T.B. , Mueller L. , Linsley P.S.
Nat. Struct. Biol.4:527-531(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 37-165
21.

"Structural basis for co-stimulation by the human CTLA-4/B7-2 complex."
Schwartz J.C. , Zhang X. , Fedorov A.A. , Nathenson S.G. , Almo S.C.
Nature410:604-608(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 36-161 IN COMPLEX WITH CD86;SUBUNIT;DISULFIDE BONDS
22.

"Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses."
Stamper C.C. , Zhang Y. , Tobin J.F. , Erbe D.V. , Ikemizu S. , Davis S.J. , Stahl M.L. , Seehra J. , Somers W.S. , Mosyak L.
Nature410:608-611(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 36-161 IN COMPLEX WITH CD80;SUBUNIT;DISULFIDE BONDS;GLYCOSYLATION AT ASN-113 AND ASN-145
23.

"Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering."
Yu C. , Sonnen A.F. , George R. , Dessailly B.H. , Stagg L.J. , Evans E.J. , Orengo C.A. , Stuart D.I. , Ladbury J.E. , Ikemizu S. , Gilbert R.J. , Davis S.J.
J. Biol. Chem.286:6685-6696(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 36-161;GLYCOSYLATION AT ASN-113;SUBUNIT;DISULFIDE BONDS
24.

"Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups."
Marron M.P. , Raffel L.J. , Garchon H.-J. , Jacob C.O. , Serrano-Rios M. , Martinez Larrad M.T. , Teng W.-P. , Park Y. , Zhang Z.-X. , Goldstein D.R. , Tao Y.-W. , Beaurain G. , Bach J.-F. , Huang H.-S. , Luo D.-F. , Zeidler A. , Rotter J.I. , Yang M.C.K. , more...
Hum. Mol. Genet.6:1275-1282(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-17;INVOLVEMENT IN IDDM12
25.

"CTLA-4 gene polymorphism is associated with predisposition to coeliac disease."
Djilali-Saiah I. , Schmitz J. , Harfouch-Hammoud E. , Mougenot J.-F. , Bach J.-F. , Caillat-Zucman S.
Gut43:187-189(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN CELIAC3
26.

"Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy."
Vaidya B. , Imrie H. , Perros P. , Dickinson J. , McCarthy M.I. , Kendall-Taylor P. , Pearce S.H.S.
Lancet354:743-744(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-17;INVOLVEMENT IN THYROID ASSOCIATED ORBITOPATHY
27.

"Complex association analysis of Graves disease using a set of polymorphic markers."
Chistyakov D.A. , Savost'anov K.V. , Turakulov R.I. , Petunina N.A. , Trukhina L.V. , Kudinova A.V. , Balabolkin M.I. , Nosikov V.V.
Mol. Genet. Metab.70:214-218(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-17;INVOLVEMENT IN GRAVES DISEASE
28.

"Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene."
Deng Z. , Morse J.H. , Slager S.L. , Cuervo N. , Moore K.J. , Venetos G. , Kalachikov S. , Cayanis E. , Fischer S.G. , Barst R.J. , Hodge S.E. , Knowles J.A.
Am. J. Hum. Genet.67:737-744(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-17
29.

"Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus."
Barreto M. , Santos E. , Ferreira R. , Fesel C. , Fontes M.F. , Pereira C. , Martins B. , Andreia R. , Viana J.F. , Crespo F. , Vasconcelos C. , Ferreira C. , Vicente A.M.
Eur. J. Hum. Genet.12:620-626(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS
30.

"Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection."
Thio C.L. , Mosbruger T.L. , Kaslow R.A. , Karp C.L. , Strathdee S.A. , Vlahov D. , O'Brien S.J. , Astemborski J. , Thomas D.L.
J. Virol.78:11258-11262(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO HBV INFECTION;VARIANT ALA-17
31.

"A common CTLA4 haplotype associated with coeliac disease."
Hunt K.A. , McGovern D.P.B. , Kumar P.J. , Ghosh S. , Travis S.P.L. , Walters J.R.F. , Jewell D.P. , Playford R.J. , van Heel D.A.
Eur. J. Hum. Genet.13:440-444(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CELIAC3
32.

"CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis."
Lee Y.H. , Harley J.B. , Nath S.K.
Hum. Genet.116:361-367(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS

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