Catenin beta-1 (Protein name
), CTNB1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
CTNNB1(OK/SW-cl.35;PRO2286;CTNNB);
Protein name:
Catenin beta-1;
Alternative:
Beta-catenin;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Two separate complex-associated pools are found in the cytoplasm. The majority is present as component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and beta-catenin/CTNNB1, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Another cytoplasmic pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited the complex dissociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF-1 family members, TBP, BCL9 and possibly also RUVBL1 and CHD8. Binds CTNNBIP and EP300. CTNNB1 forms a ternary complex with LEF1 and EP300 that is disrupted by CTNNBIP1 binding (By similarity). Interacts with TAX1BP3 (via the PDZ domain); this interaction inhibits the transcriptional activity of CTNNB1 (By similarity). Interacts with AJAP1, BAIAP1, CARM1, CTNNA3, CXADR and PCDH11Y. Binds SLC9A3R1. Interacts with GLIS2 and MUC1. Interacts with SLC30A9. Interacts with XIRP1 (By similarity). Interacts directly with AXIN1; the interaction is regulated by CDK2 phosphorylation of AXIN1 (By similarity). Interacts with SCRIB (By similarity). Interacts with PTPRU (via the cytoplasmic juxtamembrane domain). Interacts with EMD. Interacts with TNIK and TCF7L2. Interacts with SESTD1 and TRPC4. Interacts with CAV1. Interacts with TRPV4. The TRPV4 and CTNNB1 complex can interact with CDH1. Interacts with VCL (By similarity). Interacts with PTPRJ. Interacts with PKT7 and CDK2. Interacts with FAT1 (via the cytoplasmic domain) (By similarity). Interacts with NANOS1. Interacts with isoform 1 of NEK2. Interacts with both isoforms 1 and 2 of CDK5.
Function:
Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization.
Subcellular Location:
Cytoplasm
Nucleus
Cytoplasm
cytoskeleton
Cell junction
adherens junction
Cell junction
Cell membrane
Cytoplasm
cytoskeleton
centrosome
Cytoplasm
cytoskeleton
spindle pole
Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Co-localizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells.
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
NIEHS SNPs program
Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-688
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-312 (ISOFORM 1)
9.
"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients." Shichijo S.
,
Itoh K.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 258-781 (ISOFORM 1)
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Cited for: IDENTIFICATION IN AN E-CADHERIN/CATENIN ADHESION COMPLEX
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Cited for: STIMULATION OF TYROSINE PHOSPHORYLATION BY EGF;DEPHOSPHORYLATION BY PTPRF
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Cited for: INTERACTION WITH LEF1; APC; AXIN1; AXIN2 AND TCF7L2;PHOSPHORYLATION BY GSK3B;MUTAGENESIS OF PHE-253; HIS-260; LYS-292; LYS-345; TRP-383; ARG-386; ASN-426; LYS-435; ARG-469; HIS-470 AND LYS-508
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Cited for: INTERACTION WITH LEF1;INHIBITION BY CTNNBIP1 BINDING
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Cited for: PHOSPHORYLATION AT TYR-86 AND TYR-654;INTERACTION WITH TBP;MUTAGENESIS OF TYR-654
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Cited for: PHOSPHORYLATION AT SER-45;CHARACTERIZATION OF VARIANT HEPATOCELLULAR CARCINOMA ALA-41;CHARACTERIZATION OF VARIANT DESMOID TUMOR ALA-41;CHARACTERIZATION OF VARIANT HEPATOBLASTOMA ALA-41
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Cited for: PHOSPHORYLATION AT SER-23 AND SER-29 BY GSK3B;PHOSPHORYLATION AT THR-41;MUTAGENESIS OF SER-29;CHARACTERIZATION OF VARIANTS HEPATOCELLULAR CARCINOMA ARG-23; ALA-37 AND ALA-41;CHARACTERIZATION OF VARIANT PTR TYR-33;CHARACTERIZATION OF VARIANT MDB ALA-37;CHARACTERIZATION OF VARIANT DESMOID TUMOR ALA-41;CHARACTERIZATION OF VARIANT HEPATOBLASTOMA ALA-41
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Cited for: PHOSPHORYLATION;INTERACTION OF PHOSPHORYLATED CTNNB1 WITH BTRC
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-675;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: INTERACTION WITH MUC1;SUBCELLULAR LOCATION;FUNCTION
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Cited for: INTERACTION WITH GLIS2;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION AT SER-191 AND SER-246;INTERACTION WITH CDK5;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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Cited for: INTERACTION WITH FHIT;IDENTIFICATION IN A COMPLEX WITH LEF1;FUNCTION
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Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION;INTERACTION WITH NEK2
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-556 AND SER-675;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION AT TYR-64; TYR-142; TYR-331 AND TYR-333;INTERACTION WITH PTK6;MUTAGENESIS OF TYR-64
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-675;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN INSULIN INTERNALIZATION;SUBCELLULAR LOCATION;INTERACTION WITH CDK2;PHOSPHORYLATION BY CDK2
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191 AND SER-552;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION IN A COMPLEX WITH HINT1 AND MITF;FUNCTION
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Cited for: FUNCTION;INTERACTION WITH FERMT2;IDENTIFICATION IN A COMPLEX WITH FERMT2 AND TCF7L2;SUBCELLULAR LOCATION
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 133-664
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Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 134-664 IN COMPLEX WITH TCF7L2;MUTAGENESIS OF LYS-312 AND LYS-435
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Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 134-668 IN COMPLEX WITH TCF7L2
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Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 134-664 IN COMPLEX WITH CTNNBIP1;MUTAGENESIS OF PHE-660 AND ARG-661
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Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 1-136 IN COMPLEX WITH BCL9 AND TCF7L2;INTERACTION WITH BCL9; BCL9L CDH3 AND TCF7L2;MUTAGENESIS OF TYR-142; LEU-156; LEU-159 AND LEU-178
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Cited for: VARIANTS COLORECTAL CANCER TYR-33 AND SER-45 DEL
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Cited for: VARIANTS HEPATOBLASTOMA TYR-32; VAL-34; CYS-37 AND ALA-41
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Cited for: VARIANTS OVARIAN CANCER CYS-37; ILE-41 AND ALA-41
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Cited for: VARIANTS PTR GLY-32; TYR-32; PHE-33; TYR-33; GLU-34; CYS-37; PHE-37 AND ILE-41