Catsper1 ELISA Kit for Mouse(Mus musculus) | EIAab.comCatsper1 ELISA Kit for Mouse(Mus musculus)

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Catsper1 (Gene name),

Cation channel sperm-associated protein 1 (Protein name ), CTSR1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Catsper1;

Protein name:

Cation channel sperm-associated protein 1(CatSper1);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity (By similarity). Component of a complex composed at least of CATSPER1, CATSPERB, CATSPERG2 and HSPA1B. Interacts with CATSPER3 and CATSPER4.

Function:

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone.

Subcellular Location:

Cell projection cilium flagellum membrane Multi-pass membrane protein Specifically located in the principal piece of sperm tail.

Protein Attributes:

Sequence length:

686

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

500:

550:

600:

650:

686:

LVAAVEQHQQ | KFRSQAYVID | ELVDMAFEAG | DDDYGK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:225865

UniGene:

Mm.87321

String:

Q91ZR5

Pfam:

PF00520

SMR:

Q91ZR5

STRING:

10090.ENSMUSP00000045430

Uniprot:

Q91ZR5

FOR

ELISA Kit for Mouse CatSper1

CLIA Kit for Mouse CatSper1

Polyclonal Antibody for Mouse CatSper1

Monoclonal Antibody for Mouse CatSper1

Protein for Mouse CatSper1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A sperm ion channel required for sperm motility and male fertility."
Ren D. , Navarro B. , Perez G. , Jackson A.C. , Hsu S. , Shi Q. , Tilly J.L. , Clapham D.E.
Nature413:603-609(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TOPOLOGY;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
2.

"Positive selection for indel substitutions in the rodent sperm protein catsper1."
Podlaha O. , Webb D.M. , Tucker P.K. , Zhang J.
Mol. Biol. Evol.22:1845-1852(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-307;VARIANTS HIS-PRO-25 INS; ARG-52; GLN-160 DEL; ILE-270 AND SER-276
strain: 2.
strain: 35.
strain: 41.
strain: 47.
strain: 49.
strain: 51.
strain: 58.
strain: 61.
strain: 63.
strain: 72.
3.

"CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm."
Carlson A.E. , Westenbroek R.E. , Quill T. , Ren D. , Clapham D.E. , Hille B. , Garbers D.L. , Babcock D.F.
Proc. Natl. Acad. Sci. U.S.A.100:14864-14868(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility."
Nikpoor P. , Mowla S.J. , Movahedin M. , Ziaee S.A.-M. , Tiraihi T.
Hum. Reprod.19:124-128(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
5.

"Identical phenotypes of CatSper1 and CatSper2 null sperm."
Carlson A.E. , Quill T.A. , Westenbroek R.E. , Schuh S.M. , Hille B. , Babcock D.F.
J. Biol. Chem.280:32238-32244(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel."
Kirichok Y. , Navarro B. , Clapham D.E.
Nature439:737-740(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm."
Marquez B. , Ignotz G. , Suarez S.S.
Dev. Biol.303:214-221(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"CatSperbeta, a novel transmembrane protein in the CatSper channel complex."
Liu J. , Xia J. , Cho K.-H. , Clapham D.E. , Ren D.
J. Biol. Chem.282:18945-18952(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH CATSPERB AND HSPA1B
9.

"Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility."
Li H.-G. , Ding X.-F. , Liao A.-H. , Kong X.-B. , Xiong C.-L.
Mol. Hum. Reprod.13:299-306(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
10.

"All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility."
Qi H. , Moran M.M. , Navarro B. , Chong J.A. , Krapivinsky G. , Krapivinsky L. , Kirichok Y. , Ramsey I.S. , Quill T.A. , Clapham D.E.
Proc. Natl. Acad. Sci. U.S.A.104:1219-1223(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CATSPER3 AND CATSPER4
11.

"A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein."
Wang H. , Liu J. , Cho K.-H. , Ren D.
Biol. Reprod.81:539-544(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH CATSPERB; CATSPERG2 AND HSPA1B
12.

"Progesterone activates the principal Ca2+ channel of human sperm."
Lishko P.V. , Botchkina I.L. , Kirichok Y.
Nature471:387-391(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LACK OF ACTIVATION BY PROGESTERONE AND PGE1
13.

"A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa."
Chung J.J. , Navarro B. , Krapivinsky G. , Krapivinsky L. , Clapham D.E.
Nat. Commun.2:153-153(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CATSPER COMPLEX
strain: C57BL/6.

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