Catsper2 ELISA Kit for Mouse(Mus musculus) | EIAab.comCatsper2 ELISA Kit for Mouse(Mus musculus)

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Catsper2 (Gene name),

Cation channel sperm-associated protein 2 (Protein name ), CTSR2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Catsper2;

Protein name:

Cation channel sperm-associated protein 2(CatSper2);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity.

Function:

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone.

Subcellular Location:

Cell projection cilium flagellum membrane Multi-pass membrane protein Specifically located in the principal piece of sperm tail.

Protein Attributes:

Sequence length:

588

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

588:

RDSLFRYFEL | LEKLQYNLEE | RKKLQEFAVQ | ALMSFEDK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

A2ARP9

UniGene:

Mm.384318

KEGG:

mmu:212670

Pfam:

PF00520

SMR:

A2ARP9

Uniprot:

A2ARP9

FOR

ELISA Kit for Mouse CatSper2

CLIA Kit for Mouse CatSper2

Polyclonal Antibody for Mouse CatSper2

Monoclonal Antibody for Mouse CatSper2

Protein for Mouse CatSper2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A voltage-gated ion channel expressed specifically in spermatozoa."
Quill T.A. , Ren D. , Clapham D.E. , Garbers D.L.
Proc. Natl. Acad. Sci. U.S.A.98:12527-12531(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: 129/SvEv.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
4.

"Hyperactivated sperm motility driven by CatSper2 is required for fertilization."
Quill T.A. , Sugden S.A. , Rossi K.L. , Doolittle L.K. , Hammer R.E. , Garbers D.L.
Proc. Natl. Acad. Sci. U.S.A.100:14869-14874(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
5.

"Identical phenotypes of CatSper1 and CatSper2 null sperm."
Carlson A.E. , Quill T.A. , Westenbroek R.E. , Schuh S.M. , Hille B. , Babcock D.F.
J. Biol. Chem.280:32238-32244(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm."
Marquez B. , Ignotz G. , Suarez S.S.
Dev. Biol.303:214-221(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility."
Li H.-G. , Ding X.-F. , Liao A.-H. , Kong X.-B. , Xiong C.-L.
Mol. Hum. Reprod.13:299-306(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
8.

"Progesterone activates the principal Ca2+ channel of human sperm."
Lishko P.V. , Botchkina I.L. , Kirichok Y.
Nature471:387-391(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LACK OF ACTIVATION BY PROGESTERONE AND PGE1
9.

"A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa."
Chung J.J. , Navarro B. , Krapivinsky G. , Krapivinsky L. , Clapham D.E.
Nat. Commun.2:153-153(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CATSPER COMPLEX
strain: C57BL/6.

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