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Index > Protein center > CXCR2(Gene name) > Human
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  • CXCR2 (Gene name),
  • C-X-C chemokine receptor type 2 (Protein name ),  CXCR2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CXCR2(IL8RB);
    Protein name:
    C-X-C chemokine receptor type 2(CXC-R2;CXCR-2);
    Alternative:
    GRO/MGSA receptor;CDw128b;IL-8 receptor type 2;High affinity interleukin-8 receptor B(IL-8R B);
    CD:
    CD182;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    360
    Sequence:
    50:
    MEDFNMESDS | FEDFWKGEDL | SNYSYSSTLP | PFLLDAAPCE | PESLEINKYF | 
    100:
    VVIIYALVFL | LSLLGNSLVM | LVILYSRVGR | SVTDVYLLNL | ALADLLFALT | 
    150:
    LPIWAASKVN | GWIFGTFLCK | VVSLLKEVNF | YSGILLLACI | SVDRYLAIVH | 
    200:
    ATRTLTQKRY | LVKFICLSIW | GLSLLLALPV | LLFRRTVYSS | NVSPACYEDM | 
    250:
    GNNTANWRML | LRILPQSFGF | IVPLLIMLFC | YGFTLRTLFK | AHMGQKHRAM | 
    300:
    RVIFAVVLIF | LLCWLPYNLV | LLADTLMRTQ | VIQETCERRN | HIDRALDATE | 
    350:
    ILGILHSCLN | PLIYAFIGQK | FRHGLLKILA | IHGLISKDSL | PKDSRPSFVG | 
    360:
    SSSGHTSTTL | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human CXC-R2
    Cat.:
    E2006b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human CXC-R2
    Cat.:
    E2006h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human CXC-R2
    Cat.:
    E2006r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human CXC-R2
    Cat.:
    E2006d
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human CXC-R2
    MSDS:
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    ELISA Kit for Human CXC-R2
    Cat.:
    E2006m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human CXC-R2
    Cat.:
    U2006h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CXC-R2
    Cat.:
    U2006r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CXC-R2
    Cat.:
    U2006m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CXC-R2
    MSDS:
    Please sign in first.
    CLIA Kit for Human CXC-R2
    Cat.:
    U2006b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CXC-R2
    Cat.:
    U2006d
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human CXC-R2
    Cat.:
    P2006Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CXC-R2
    Polyclonal Antibody for Human CXC-R2
    Polyclonal Antibody for Human CXC-R2
    Cat.:
    P2006Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CXC-R2
    Polyclonal Antibody for Human CXC-R2
    Cat.:
    P2006Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human CXC-R2
    Monoclonal Antibody for Human CXC-R2
    Monoclonal Antibody for Human CXC-R2
    Monoclonal Antibody for Human CXC-R2
    Monoclonal Antibody for Human CXC-R2
    Monoclonal Antibody for Human CXC-R2
    Protein for Human CXC-R2
    Protein for Human CXC-R2
    Protein for Human CXC-R2
    Protein for Human CXC-R2
    Protein for Human CXC-R2
    Protein for Human CXC-R2

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    Citations
    References
    1. 1.
      "Cloning of complementary DNA encoding a functional human interleukin-8 receptor."
      Murphy P.M. , Tiffany H.L.
      Science253:1280-1283(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2."
      Cerretti D.P. , Kozlosky C.J. , Vanden Bos T. , Nelson N. , Gearing D.P. , Beckmann M.P.
      Mol. Immunol.30:359-367(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION
    3. 3.
      "Structure, genomic organization, and expression of the human interleukin-8 receptor B gene."
      Sprenger H. , Lloyd A.R. , Lautens L.L. , Bonner T.I. , Kelvin D.J.
      J. Biol. Chem.269:11065-11072(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    4. 4.
      "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B."
      Ahuja S.K. , Shetty A. , Tiffany H.L. , Murphy P.M.
      J. Biol. Chem.269:26381-26389(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2004-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    7. 7.
      "Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3."
      Kato H. , Tsuchiya N. , Tokunaga K.
      Genes Immun.1:330-337(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-162 AND 191-301;VARIANT CYS-80
    8. 8.
      "Characterization of two high affinity human interleukin-8 receptors."
      Lee J. , Horuk R. , Rice G.C. , Bennett G.L. , Camerato T. , Wood W.I.
      J. Biol. Chem.267:16283-16287(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    9. 9.
      "Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor."
      Mueller S.G. , White J.R. , Schraw W.P. , Lam V. , Richmond A.
      J. Biol. Chem.272:8207-8214(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-347; SER-351; SER-352 AND SER-353
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