CXCR4 ELISA Kit for Dog(Canis familiaris) | EIAab.comCXCR4 ELISA Kit for Dog(Canis familiaris)

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Index > Protein center > CXCR4(Gene name) > Dog

CXCR4 (Gene name),

C-X-C chemokine receptor type 4 (Protein name ), CXCR4_CANFA from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

CXCR4;

Protein name:

C-X-C chemokine receptor type 4(CXC-R4;CXCR-4);

Alternative:

CD:

CD184;

Organism:

Dog (Canis familiarisCanis lupus familiaris).

General Annotation

Sub Unit:

Monomer (By similarity). Can form dimers (By similarity). Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin; the interaction enhances intracellular calcium ions and reduces cellular cAMP levels.

Function:

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

Subcellular Location:

Cell membrane Multi-pass membrane protein In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated.

Protein Attributes:

Sequence length:

353

Sequence:

50:

100:

150:

200:

250:

300:

350:

353:

HSS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00001

String:

Q3LSL6

KEGG:

cfa:483900

UniGene:

Cfa.16645

STRING:

9615.ENSCAFP00000007600

Uniprot:

Q3LSL6

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ELISA Kit for Dog CXC-R4

Cat.:

E2170h

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Packing:

96T

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ELISA Kit for Dog CXC-R4

Cat.:

E2170p

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96T

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ELISA Kit for Dog CXC-R4

Cat.:

E2170b

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96T

ELISA Kit for Dog CXC-R4

Cat.:

E2170m

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96T

ELISA Kit for Dog CXC-R4

Cat.:

E2170d

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MSDS:

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96T

ELISA Kit for Dog CXC-R4

Cat.:

E2170r

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Packing:

96T

CLIA Kit for Dog CXC-R4

Cat.:

U2170p

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MSDS:

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Packing:

96T

CLIA Kit for Dog CXC-R4

Cat.:

U2170b

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MSDS:

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Packing:

96T

CLIA Kit for Dog CXC-R4

Cat.:

U2170m

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MSDS:

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Packing:

96T

CLIA Kit for Dog CXC-R4

Cat.:

U2170h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Dog CXC-R4

Cat.:

U2170r

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MSDS:

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Packing:

96T

CLIA Kit for Dog CXC-R4

Cat.:

U2170d

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Packing:

96T

Polyclonal Antibody for Dog CXC-R4

Cat.:

P2170Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Dog CXC-R4

Cat.:

P2170Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Dog CXC-R4

Cat.:

P2170Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Dog CXC-R4

Protein for Dog CXC-R4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Evaluation of the canine CXCR4 and CXCL12 genes as a candidate for chronic neutropenia with myelokathexis in a border collie dog."
Tsuchida S. , Kagi A. , Takahashi T.
Submitted (2005-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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