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Index > Protein center > Ddc(Gene name) > Rat
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  • Ddc (Gene name),
  • Aromatic-L-amino-acid decarboxylase (Protein name ),  DDC_RAT from NCBI database.
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  • General Annotation
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  • Gene name:
    Ddc;
    Protein name:
    Aromatic-L-amino-acid decarboxylase(AADC);
    Alternative:
    DOPA decarboxylase(DDC);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    480
    Sequence:
    50:
    MDSREFRRRG | KEMVDYIADY | LDGIEGRPVY | PDVEPGYLRA | LIPTTAPQEP | 
    100:
    ETYEDIIRDI | EKIIMPGVTH | WHSPYFFAYF | PTASSYPAML | ADMLCGAIGC | 
    150:
    IGFSWAASPA | CTELETVMMD | WLGKMLELPE | AFLAGRAGEG | GGVIQGSASE | 
    200:
    ATLVALLAAR | TKMIRQLQAA | SPELTQAALM | EKLVAYTSDQ | AHSSVERAGL | 
    250:
    IGGVKIKAIP | SDGNYSMRAA | ALREALERDK | AAGLIPFFVV | VTLGTTSCCS | 
    300:
    FDNLLEVGPI | CNQEGVWLHI | DAAYAGSAFI | CPEFRYLLNG | VEFADSFNFN | 
    350:
    PHKWLLVNFD | CSAMWVKKRT | DLTEAFNMDP | VYLRHSHQDS | GLITDYRHWQ | 
    400:
    IPLGRRFRSL | KMWFVFRMYG | VKGLQAYIRK | HVKLSHEFES | LVRQDPRFEI | 
    450:
    CTEVILGLVC | FRLKGSNQLN | ETLLQRINSA | KKIHLVPCRL | RDKFVLRFAV | 
    480:
    CSRTVESAHV | QLAWEHIRDL | ASSVLRAEKE | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat AADC
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    E1431h
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    ELISA Kit for Rat AADC
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    ELISA Kit for Rat AADC
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    E1431r
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    ELISA Kit for Rat AADC
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    E1431b
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    ELISA Kit for Rat AADC
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    E1431p
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    CLIA Kit for Rat AADC
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    U1431p
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    96T
    CLIA Kit for Rat AADC
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    U1431r
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    96T
    CLIA Kit for Rat AADC
    Cat.:
    U1431b
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    96T
    CLIA Kit for Rat AADC
    Cat.:
    U1431m
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    Packing:
    96T
    CLIA Kit for Rat AADC
    Cat.:
    U1431h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Rat AADC
    Polyclonal Antibody for Rat AADC
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    P1431Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat AADC
    Polyclonal Antibody for Rat AADC
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    P1431Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat AADC
    Cat.:
    P1431Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat AADC
    Monoclonal Antibody for Rat AADC
    Monoclonal Antibody for Rat AADC
    Monoclonal Antibody for Rat AADC
    Monoclonal Antibody for Rat AADC
    Protein for Rat AADC
    Protein for Rat AADC
    Protein for Rat AADC
    Protein for Rat AADC
    Protein for Rat AADC

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    References
    1. 1.
      "Molecular cloning and sequencing of a cDNA of rat dopa decarboxylase: partial amino acid homologies with other enzymes synthesizing catecholamines."
      Tanaka T. , Horio Y. , Taketoshi M. , Imamura I. , Ando-Yamamoto M. , Kangawa K. , Matsuo H. , Kurodo M. , Wada H.
      Proc. Natl. Acad. Sci. U.S.A.86:8142-8146(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    3. 3.
      "Distinct promoters direct neuronal and nonneuronal expression of rat aromatic L-amino acid decarboxylase."
      Albert V.R. , Lee M.R. , Bolden A.H. , Wurzburger R.J. , Aguanno A.
      Proc. Natl. Acad. Sci. U.S.A.89:12053-12057(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67
      strain: Sprague-Dawley.
    4. 4.
      "Functionally important residues of aromatic L-amino acid decarboxylase probed by sequence alignment and site-directed mutagenesis."
      Ishii S. , Mizugichi H. , Nishino J. , Hayashi H. , Kagamiyama H.
      J. Biochem.120:369-376(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF HIS-192; ASP-252; ASP-271; SER-296; LYS-303; TYR-332 AND ARG-355;COFACTOR
    5. 5.
      "Mutation of residues in the coenzyme binding pocket of Dopa decarboxylase. Effects on catalytic properties."
      Bertoldi M. , Castellani S. , Bori Voltattorni C.
      Eur. J. Biochem.268:2975-2981(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF HIS-192; ASP-271; ASN-300 AND HIS-302
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