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Index > Protein center > HSD17B12(Gene name) > Human
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  • HSD17B12 (Gene name),
  • Estradiol 17-beta-dehydrogenase 12 (Protein name ),  DHB12_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HSD17B12;
    Protein name:
    Estradiol 17-beta-dehydrogenase 12;
    Alternative:
    1.3.1.-;3-ketoacyl-CoA reductase(KAR);17-beta-hydroxysteroid dehydrogenase 12(17-beta-HSD 12);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ELOVL1 and LASS2.
    Function:
    Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    312
    Sequence:
    50:
    MESALPAAGF | LYWVGAGTVA | YLALRISYSL | FTALRVWGVG | NEAGVGPGLG | 
    100:
    EWAVVTGSTD | GIGKSYAEEL | AKHGMKVVLI | SRSKDKLDQV | SSEIKEKFKV | 
    150:
    ETRTIAVDFA | SEDIYDKIKT | GLAGLEIGIL | VNNVGMSYEY | PEYFLDVPDL | 
    200:
    DNVIKKMINI | NILSVCKMTQ | LVLPGMVERS | KGAILNISSG | SGMLPVPLLT | 
    250:
    IYSATKTFVD | FFSQCLHEEY | RSKGVFVQSV | LPYFVATKLA | KIRKPTLDKP | 
    300:
    SPETFVKSAI | KTVGLQSRTN | GYLIHALMGS | IISNLPSWIY | LKIVMNMNKS | 
    312:
    TRAHYLKKTK | KN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Estradiol 17-beta-dehydrogenase 12
    ELISA Kit for Human Estradiol 17-beta-dehydrogenase 12
    ELISA Kit for Human Estradiol 17-beta-dehydrogenase 12
    ELISA Kit for Human Estradiol 17-beta-dehydrogenase 12
    CLIA Kit for Human Estradiol 17-beta-dehydrogenase 12
    CLIA Kit for Human Estradiol 17-beta-dehydrogenase 12
    CLIA Kit for Human Estradiol 17-beta-dehydrogenase 12
    CLIA Kit for Human Estradiol 17-beta-dehydrogenase 12
    Polyclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
    Polyclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
    Polyclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
    Polyclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
    Monoclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
    Monoclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
    Monoclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
    Monoclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
    Protein for Human Estradiol 17-beta-dehydrogenase 12
    Protein for Human Estradiol 17-beta-dehydrogenase 12
    Protein for Human Estradiol 17-beta-dehydrogenase 12
    Protein for Human Estradiol 17-beta-dehydrogenase 12

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    Linearity
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    References
    1. 1.
      "Human steroid dehydrogenase homologue, complete cds."
      Liu T. , Zhang J. , Fu G. , Zhang Q. , Ye M. , Zhou J. , Wu J. , Shen Y. , Yu M. , Chen S. , Mao M. , Chen Z.
      Submitted (1998-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-280
      tissue: Liver.
      tissue: Placenta.
      tissue: Thymus.
      tissue: Thyroid.
    3. 3.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-280
      tissue: Liver.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEU-280
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
      tissue: Pancreas.
    7. 7.
      Bienvenut W.V.
      Submitted (2005-06) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-35; 65-72; 104-117; 157-179 AND 207-221;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: B-cell lymphoma.
    8. 8.
      "Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade."
      Moon Y.-A. , Horton J.D.
      J. Biol. Chem.278:7335-7343(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    9. 9.
      "Platelets express steroidogenic 17beta-hydroxysteroid dehydrogenases. Distinct profiles predict the essential thrombocythemic phenotype."
      Gnatenko D.V. , Cupit L.D. , Huang E.C. , Dhundale A. , Perrotta P.L. , Bahou W.F.
      Thromb. Haemost.94:412-421(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    10. 10.
      "Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women."
      Luu-The V. , Tremblay P. , Labrie F.
      Mol. Endocrinol.20:437-443(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY;MUTAGENESIS OF VAL-196 AND PHE-234
    11. 11.
      "ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis."
      Ohno Y. , Suto S. , Yamanaka M. , Mizutani Y. , Mitsutake S. , Igarashi Y. , Sassa T. , Kihara A.
      Proc. Natl. Acad. Sci. U.S.A.107:18439-18444(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ELOVL1 AND LASS2
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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