Protein name:
Estradiol 17-beta-dehydrogenase 12 ;
Alternative:
1.3.1.-;3-ketoacyl-CoA reductase (KAR) ;17-beta-hydroxysteroid dehydrogenase 12 (17-beta-HSD 12) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with ELOVL1 and LASS2.
Function:
Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Protein Attributes:
50:
MESALPAAGF | LYWVGAGTVA | YLALRISYSL | FTALRVWGVG | NEAGVGPGLG |
100:
EWAVVTGSTD | GIGKSYAEEL | AKHGMKVVLI | SRSKDKLDQV | SSEIKEKFKV |
150:
ETRTIAVDFA | SEDIYDKIKT | GLAGLEIGIL | VNNVGMSYEY | PEYFLDVPDL |
200:
DNVIKKMINI | NILSVCKMTQ | LVLPGMVERS | KGAILNISSG | SGMLPVPLLT |
250:
IYSATKTFVD | FFSQCLHEEY | RSKGVFVQSV | LPYFVATKLA | KIRKPTLDKP |
300:
SPETFVKSAI | KTVGLQSRTN | GYLIHALMGS | IISNLPSWIY | LKIVMNMNKS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Human
Mouse
ELISA Kit for Human Estradiol 17-beta-dehydrogenase 12
ELISA Kit for Human Estradiol 17-beta-dehydrogenase 12
ELISA Kit for Human Estradiol 17-beta-dehydrogenase 12
ELISA Kit for Human Estradiol 17-beta-dehydrogenase 12
CLIA Kit for Human Estradiol 17-beta-dehydrogenase 12
CLIA Kit for Human Estradiol 17-beta-dehydrogenase 12
CLIA Kit for Human Estradiol 17-beta-dehydrogenase 12
CLIA Kit for Human Estradiol 17-beta-dehydrogenase 12
Polyclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
Polyclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
Polyclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
Polyclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
Monoclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
Monoclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
Monoclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
Monoclonal Antibody for Human Estradiol 17-beta-dehydrogenase 12
Protein for Human Estradiol 17-beta-dehydrogenase 12
Protein for Human Estradiol 17-beta-dehydrogenase 12
Protein for Human Estradiol 17-beta-dehydrogenase 12
Protein for Human Estradiol 17-beta-dehydrogenase 12
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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Nat. Genet.36:40-45(2004)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-280
tissue :
Liver .
tissue :
Placenta .
tissue :
Thymus .
tissue :
Thyroid .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-280
tissue :
Liver .
4.
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEU-280
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Brain .
tissue :
Pancreas .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 26-35; 65-72; 104-117; 157-179 AND 207-221;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
B-cell lymphoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY;MUTAGENESIS OF VAL-196 AND PHE-234
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ELOVL1 AND LASS2
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]