HSD17B1 ELISA Kit for Human(Homo sapiens) | EIAab.comHSD17B1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HSD17B1(Gene name) > Human

HSD17B1 (Gene name),

Estradiol 17-beta-dehydrogenase 1 (Protein name ), DHB1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HSD17B1(E17KSR;EDH17B1;EDH17B2;EDHB17);

Protein name:

Estradiol 17-beta-dehydrogenase 1;

Alternative:

20 alpha-hydroxysteroid dehydrogenase(20-alpha-HSD);17-beta-hydroxysteroid dehydrogenase type 1(17-beta-HSD 1);Placental 17-beta-hydroxysteroid dehydrogenase;E2DH;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

328

Sequence:

50:

100:

150:

200:

250:

300:

328:

GAGPGAEDEA | GRGAVGDPEL | GDPPAAPQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:3292

SMR:

P14061

UniGene:

Hs.654385

Pfam:

PF00106

MIM:

109684

String:

P14061

STRING:

9606.ENSP00000225929

Uniprot:

P14061

FOR

ELISA Kit for Human Estradiol 17-beta-dehydrogenase 1

CLIA Kit for Human Estradiol 17-beta-dehydrogenase 1

Polyclonal Antibody for Human Estradiol 17-beta-dehydrogenase 1

Monoclonal Antibody for Human Estradiol 17-beta-dehydrogenase 1

Protein for Human Estradiol 17-beta-dehydrogenase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA."
Peltoketo H. , Isomaa V. , Maeentausta O. , Vihko R.
FEBS Lett.239:73-77(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-313
tissue: Placenta.
2.

"Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta."
Luu-The V. , Labrie C. , Zhao H.F. , Couet J. , Lachance Y. , Simard J. , Leblanc G. , Labrie F.
Mol. Endocrinol.3:1301-1309(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-313
tissue: Placenta.
3.

"Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes."
Luu-The V. , Labrie C. , Simard J. , Lachance Y. , Zhao H.F. , Couet J. , Leblanc G. , Labrie F.
Mol. Endocrinol.4:268-275(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-313
4.

"Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase."
Luu-The V. , Labrie C. , Zhao H.F. , Couet J. , Lachance Y. , Simard J. , Cote J. , Leblanc G. , Lagace L. , Berube D. , Gagne R. , Labrie F.
Ann. N. Y. Acad. Sci.595:40-52(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-313
5.

"Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements."
Peltoketo H.E. , Isomma V. , Vihko R.
Eur. J. Biochem.209:459-466(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-313
6.

Shen Y. , Gibbs R.A.
Submitted (1995-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-313
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT SER-313
tissue: Placenta.
8.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-313
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT SER-313
tissue: Brain.
11.

"Amino acid composition and subunit structure. Human placental 17 -estradiol dehydrogenase."
Burns D.J.W. , Engel L.L. , Bethune J.L.
Biochemistry11:2699-2703(1972) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-6
12.

"Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine."
Nicholas J.C. , Harris J.I.
FEBS Lett.29:173-176(1973) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 52-68
13.

"Human placental estradiol 17 beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region."
Murdock G.L. , Chin C.-C. , Warren J.C.
Biochemistry25:641-646(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 205-224
14.

"Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione."
Murdock G.L. , Chin C.C. , Offord R.E. , Bradshaw R.A. , Warren J.C.
J. Biol. Chem.258:11460-11464(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 220-224
15.

"Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti."
Baker M.E.
Mol. Endocrinol.3:881-884(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIMILARITY TO SHORT CHAIN DEHYDROGENASES
16.

"Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20-A resolution."
Ghosh D. , Pletnev V.Z. , Zhu D.W. , Wawrzak Z. , Duax W.L. , Pangborn W. , Labrie F. , Lin S.-X.
Structure3:503-513(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS)
17.

"Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol."
Azzi A. , Rehse P.H. , Zhu D.W. , Campbell R.L. , Labrie F. , Lin S.X.
Nat. Struct. Biol.3:665-668(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
18.

"The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors."
Breton R. , Housset D. , Mazza C. , Fontecilla-Camps J.-C.
Structure4:905-915(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH SUBSTRATE AND NADP
19.

"Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase."
Mazza C. , Breton R. , Housset D. , Fontecilla-Camps J.-C.
J. Biol. Chem.273:8145-8152(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS)
20.

"Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+."
Sawicki M.W. , Erman M. , Puranen T. , Vihko P. , Ghosh D.
Proc. Natl. Acad. Sci. U.S.A.96:840-845(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS)
21.

"Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain."
Han Q. , Campbell R.L. , Gangloff A. , Huang Y.-W. , Lin S.-X.
J. Biol. Chem.275:1105-1111(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 39-328;MUTAGENESIS OF LEU-150
22.

"A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity."
Qiu W. , Campbell R.L. , Gangloff A. , Dupuis P. , Boivin R.P. , Tremblay M.R. , Poirier D. , Lin S.X.
FASEB J.16:1829-1831(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS)
23.

"Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase."
Gangloff A. , Shi R. , Nahoum V. , Lin S.X.
FASEB J.17:274-276(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS)
24.

"Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation."
Shi R. , Lin S.X.
J. Biol. Chem.279:16778-16785(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS)
25.

"Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21."
Normand T. , Narod S. , Labrie F. , Simard J.
Hum. Mol. Genet.2:479-483(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-238 AND SER-313

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