DICER1 ELISA Kit for Human(Homo sapiens) | EIAab.comDICER1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > DICER1(Gene name) > Human

DICER1 (Gene name),

Endoribonuclease Dicer (Protein name ), DICER_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

DICER1(DICER;HERNA;KIAA0928);

Protein name:

Endoribonuclease Dicer;

Alternative:

Helicase with RNase motif(Helicase MOI);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, EIF2C1, PIWIL1 and PRKRA. Associates with the 60S ribosome.

Function:

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1922

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1922:

KSAAARRALR | SLKANQPQVP | NS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

SMR:

Q9UPY3

Pfam:

PF00270

KEGG:

hsa:23405

UniGene:

Hs.87889

STRING:

9606.ENSP00000343745

String:

Q9UPY3

MIM:

138800

Uniprot:

Q9UPY3

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ELISA Kit for Human Endoribonuclease Dicer

Cat.:

E0156h

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96T

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ELISA Kit for Human Endoribonuclease Dicer

Cat.:

E0156m

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96T

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ELISA Kit for Human Endoribonuclease Dicer

Cat.:

E0156c

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Packing:

96T

ELISA Kit for Human Endoribonuclease Dicer

Cat.:

E0156b

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Packing:

96T

CLIA Kit for Human Endoribonuclease Dicer

Cat.:

U0156b

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Packing:

96T

CLIA Kit for Human Endoribonuclease Dicer

Cat.:

U0156c

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96T

CLIA Kit for Human Endoribonuclease Dicer

Cat.:

U0156h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Endoribonuclease Dicer

Cat.:

U0156m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Endoribonuclease Dicer

Cat.:

P0156Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Endoribonuclease Dicer

Cat.:

P0156Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Endoribonuclease Dicer

Protein for Human Endoribonuclease Dicer

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase."
Matsuda S. , Ichigotani Y. , Okuda T. , Irimura T. , Nakatsugawa S. , Hamaguchi M.
Biochim. Biophys. Acta1490:163-169(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"A novel splice variant of the human dicer gene is expressed in neuroblastoma cells."
Potenza N. , Papa U. , Scaruffi P. , Mosca N. , Tonini G.P. , Russo A.
FEBS Lett.584:3452-3457(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
tissue: Neuroblastoma.
3.

"RNA binding and processing by recombinant human Dicer."
Provost P. , Dishart D. , Doucet D. , Hermansson A. , Frendewey D. , Samuelsson B. , Radmark O.
Submitted (2002-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Lung.
4.

"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.6:63-70(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
5.

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Brain.
7.

"The DNA sequence and analysis of human chromosome 14."
Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
10.

"Interaction of 5-lipoxygenase with cellular proteins."
Provost P. , Samuelsson B. , Radmark O.
Proc. Natl. Acad. Sci. U.S.A.96:1881-1885(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1248-1922 (ISOFORM 1)
tissue: Lung.
11.

"Single processing center models for human Dicer and bacterial RNase III."
Zhang H. , Kolb F.A. , Jaskiewicz L. , Westhof E. , Filipowicz W.
Cell118:57-68(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF GLU-1313; ASP-1320; GLU-1340; GLU-1444; GLN-1702; ASP-1709; PRO-1729 AND GLU-1813
12.

"Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer."
Tahbaz N. , Kolb F.A. , Zhang H. , Jaronczyk K. , Filipowicz W. , Hobman T.C.
EMBO Rep.5:189-194(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIWIL1
13.

"Human RISC couples microRNA biogenesis and posttranscriptional gene silencing."
Gregory R.I. , Chendrimada T.P. , Cooch N. , Shiekhattar R.
Cell123:631-640(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AGO2 AND TARBP2
14.

"Identification of novel argonaute-associated proteins."
Meister G. , Landthaler M. , Peters L. , Chen P.Y. , Urlaub H. , Luehrmann R. , Tuschl T.
Curr. Biol.15:2149-2155(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH AGO1 AND AGO2
15.

"TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing."
Haase A.D. , Jaskiewicz L. , Zhang H. , Laine S. , Sack R. , Gatignol A. , Filipowicz W.
EMBO Rep.6:961-967(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TARBP2
16.

"A human, ATP-independent, RISC assembly machine fueled by pre-miRNA."
Maniataki E. , Mourelatos Z.
Genes Dev.19:2979-2990(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AGO2
17.

"TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing."
Chendrimada T.P. , Gregory R.I. , Kumaraswamy E. , Norman J. , Cooch N. , Nishikura K. , Shiekhattar R.
Nature436:740-744(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH AGO2 AND TARBP2
18.

"The role of PACT in the RNA silencing pathway."
Lee Y. , Hur I. , Park S.-Y. , Kim Y.-K. , Suh M.R. , Kim V.N.
EMBO J.25:522-532(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PRKRA AND TARBP2;SUBCELLULAR LOCATION
19.

"Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA."
Kok K.H. , Ng M.-H. , Ching Y.-P. , Jin D.-Y.
J. Biol. Chem.282:17649-17657(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PRKRA AND TARBP2
20.

"RNA helicase A interacts with RISC in human cells and functions in RISC loading."
Robb G.B. , Rana T.M.
Mol. Cell26:523-537(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DHX9
21.

"MicroRNA silencing through RISC recruitment of eIF6."
Chendrimada T.P. , Finn K.J. , Ji X. , Baillat D. , Gregory R.I. , Liebhaber S.A. , Pasquinelli A.E. , Shiekhattar R.
Nature447:823-828(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH AGO2; EIF6; MOV10 AND TARBP2;ASSOCIATION WITH THE 60S RIBOSOME
22.

"Prolyl 4-hydroxylation regulates Argonaute 2 stability."
Qi H.H. , Ongusaha P.P. , Myllyharju J. , Cheng D. , Pakkanen O. , Shi Y. , Lee S.W. , Peng J. , Shi Y.
Nature455:421-424(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH AGO2
23.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
24.

"In vitro reconstitution of the human RISC-loading complex."
MacRae I.J. , Ma E. , Zhou M. , Robinson C.V. , Doudna J.A.
Proc. Natl. Acad. Sci. U.S.A.105:512-517(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH AGO2 AND TARBP2
25.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function."
Melo S.A. , Ropero S. , Moutinho C. , Aaltonen L.A. , Yamamoto H. , Calin G.A. , Rossi S. , Fernandez A.F. , Carneiro F. , Oliveira C. , Ferreira B. , Liu C.-G. , Villanueva A. , Capella G. , Schwartz S. Jr. , Shiekhattar R. , Esteller M.
Nat. Genet.41:365-370(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
27.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
28.

"Extending the phenotypes associated with DICER1 mutations."
Foulkes W.D. , Bahubeshi A. , Hamel N. , Pasini B. , Asioli S. , Baynam G. , Choong C.S. , Charles A. , Frieder R.P. , Dishop M.K. , Graf N. , Ekim M. , Bouron-Dal Soglio D. , Arseneau J. , Young R.H. , Sabbaghian N. , Srivastava A. , Tischkowitz M.D. , more...
Hum. Mutat.32:1381-1384(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMET IN RMSE2
29.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413 AND SER-415;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
30.

"Human RNA methyltransferase BCDIN3D regulates microRNA processing."
Xhemalce B. , Robson S.C. , Kouzarides T.
Cell151:278-288(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCDIN3D
31.

"Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers."
Heravi-Moussavi A. , Anglesio M.S. , Cheng S.W. , Senz J. , Yang W. , Prentice L. , Fejes A.P. , Chow C. , Tone A. , Kalloger S.E. , Hamel N. , Roth A. , Ha G. , Wan A.N. , Maines-Bandiera S. , Salamanca C. , Pasini B. , Clarke B.A. , more...
N. Engl. J. Med.366:234-242(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN NON-EPITHELIAL OVARIAN TUMORS;VARIANTS LYS-1705; ASN-1709; GLU-1709; GLY-1709; HIS-1810; TYR-1810; ASN-1810; GLN-1813; GLY-1813 AND LYS-1813;CHARACTERIZATION OF VARIANTS LYS-1705; ASN-1709 AND GLU-1709
32.

"Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer."
Takeshita D. , Zenno S. , Lee W.C. , Nagata K. , Saigo K. , Tanokura M.
J. Mol. Biol.374:106-120(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1660-1852;CATALYTIC ACTIVITY;COFACTOR;SUBUNIT
33.

"DICER1 mutations in familial pleuropulmonary blastoma."
Hill D.A. , Ivanovich J. , Priest J.R. , Gurnett C.A. , Dehner L.P. , Desruisseau D. , Jarzembowski J.A. , Wikenheiser-Brokamp K.A. , Suarez B.K. , Whelan A.J. , Williams G. , Bracamontes D. , Messinger Y. , Goodfellow P.J.
Science325:965-965(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPB ARG-1583
34.

"DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors."
Rio Frio T. , Bahubeshi A. , Kanellopoulou C. , Hamel N. , Niedziela M. , Sabbaghian N. , Pouchet C. , Gilbert L. , O'Brien P.K. , Serfas K. , Broderick P. , Houlston R.S. , Lesueur F. , Bonora E. , Muljo S. , Schimke R.N. , Bouron-Dal Soglio D. , Arseneau J. , more...
JAMA305:68-77(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MNG1 PHE-839

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