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Index > Protein center > DKK1(Gene name) > Human
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  • DKK1 (Gene name),
  • Dickkopf-related protein 1 (Protein name ),  DKK1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DKK1(UNQ492/PRO1008);
    Protein name:
    Dickkopf-related protein 1(Dickkopf-1;Dkk-1;hDkk-1);
    Alternative:
    SK;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with LRP6. Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling.
    Function:
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    266
    Sequence:
    50:
    MMALGAAGAT | RVFVAMVAAA | LGGHPLLGVS | ATLNSVLNSN | AIKNLPPPLG | 
    100:
    GAAGHPGSAV | SAAPGILYPG | GNKYQTIDNY | QPYPCAEDEE | CGTDEYCASP | 
    150:
    TRGGDAGVQI | CLACRKRRKR | CMRHAMCCPG | NYCKNGICVS | SDQNHFRGEI | 
    200:
    EETITESFGN | DHSTLDGYSR | RTTLSSKMYH | TKGQEGSVCL | RSSDCASGLC | 
    250:
    CARHFWSKIC | KPVLKEGQVC | TKHRRKGSHG | LEIFQRCYCG | EGLSCRIQKD | 
    266:
    HHQASNSSRL | HTCQRH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    Pfam:
    KEGG:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Dickkopf-1
    Cat.:
    E0741h
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    96T
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    ELISA Kit for Human Dickkopf-1
    Cat.:
    E0741m
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Dickkopf-1
    Cat.:
    U0741h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Dickkopf-1
    Cat.:
    U0741m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Dickkopf-1
    Cat.:
    P0741Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dickkopf-1
    Cat.:
    P0741Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Dickkopf-1
    Monoclonal Antibody for Human Dickkopf-1
    Protein for Human Dickkopf-1
    Protein for Human Dickkopf-1

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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling."
      Fedi P. , Bafico A. , Nieto Soria A. , Burgess W.H. , Miki T. , Bottaro D.P. , Kraus M.H. , Aaronson S.A.
      J. Biol. Chem.274:19465-19472(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Leiomyosarcoma.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Fetal kidney.
    3. 3.
      Tate G. , Suzuki T. , Mitsuya T.
      Submitted (1998-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly."
      Roessler E. , Du Y. , Glinka A. , Dutra A. , Niehrs C. , Muenke M.
      Cytogenet. Cell Genet.89:220-224(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Cerebellum.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    9. 9.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 32-46
    10. 10.
      "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6."
      Semenov M.V. , Tamai K. , Brott B.K. , Kuhl M. , Sokol S. , He X.
      Curr. Biol.11:951-961(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP6
    11. 11.
      "Function and biological roles of the Dickkopf family of Wnt modulators."
      Niehrs C.
      Oncogene25:7469-7481(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW OF THE DKK FAMILY
    12. 12.
      "A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V)."
      Murrills R.J. , Matteo J.J. , Bhat B.M. , Coleburn V.E. , Allen K.M. , Chen W. , Damagnez V. , Bhat R.A. , Bex F.J. , Bodine P.V.
      J. Cell. Biochem.108:1066-1075(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP5
    13. 13.
      "Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."
      Bourhis E. , Tam C. , Franke Y. , Bazan J.F. , Ernst J. , Hwang J. , Costa M. , Cochran A.G. , Hannoush R.N.
      J. Biol. Chem.285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP6
    14. 14.
      "Human Dickkopf-1 (huDKK1) protein: characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains."
      Haniu M. , Horan T. , Spahr C. , Hui J. , Fan W. , Chen C. , Richards W.G. , Lu H.S.
      Protein Sci.20:1802-1813(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-61 AND ASN-256;DISULFIDE BONDS
    15. 15.
      "Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6."
      Ahn V.E. , Chu M.L. , Choi H.J. , Tran D. , Abo A. , Weis W.I.
      Dev. Cell21:862-873(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 178-266 IN COMPLEX WITH LRP6;FUNCTION;DISULFIDE BONDS
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