Dmtf1 ELISA Kit for Mouse(Mus musculus) | EIAab.comDmtf1 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Dmtf1 (Gene name),

Cyclin-D-binding Myb-like transcription factor 1 (Protein name ), DMTF1_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

Dmtf1(Dmp1);

Protein name:

Cyclin-D-binding Myb-like transcription factor 1;

Alternative:

Cyclin-D-interacting Myb-like protein 1(mDmp1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with the D-type cyclins CCND1, CCND2 and CCND3. Interaction with D-type cyclins may modulate transcriptional activation by this protein.

Function:

Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. May also cooperate with MYB to activate transcription of the ANPEP gene. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

761

Sequence:

50:

MSTVEEDSDT | VTVETVNSVT | FTQDTDGNLI | LHCPQNDPDE | VDSEDSTEPP |

100:

HKRLCLSSED | DQSIDDATPC | ISVVALPLSE | NDQSFEVTMT | ATTEVADDEL |

150:

SEGTVTQIQI | LQNDQLDEIS | PLGTEEVSAV | SQAWFTTKED | KDSLTNKGHK |

200:

WKQGMWSKEE | IDILMNNIER | YLKARGIKDA | TEIIFEMSKD | ERKDFYRTIA |

250:

WGLNRPLFAV | YRRVLRMYDD | RNHVGKYTPE | EIEKLKELRI | KHGNDWATIG |

300:

AALGRSASSV | KDRCRLMKDT | CNTGKWTEEE | EKRLAEVVHE | LTSTEPGDIV |

350:

TQGVSWAAVA | ERVGTRSEKQ | CRSKWLNYLN | WKQSGGTEWT | KEDEINLILR |

400:

IAELDVADEN | DINWDLLAEG | WSSVRSPQWL | RSKWWTIKRQ | IANHKDVSFP |

450:

VLIKGLKQLH | ENQKNNPVLL | ENKSGSGVPN | SNCNSSVQHV | QIRVARLEDN |

500:

TAISPSPMAA | LQIPVQITHV | SSTDSPAASV | DSETITLNSG | TLQTFEILPS |

550:

FHLQPTGTPG | TYLLQTSSSQ | GLPLTLTTNP | TVTLAAAAPA | SPEQIIVHAL |

600:

SPEHLLNTSD | NVTVQCHTPR | VIIQTVATED | ITSSLSQEEL | TVDSDLHSSD |

650:

FPEPPDALEA | DTFPDEIPRP | KMTIQPSFNN | AHVSKFSDQN | STELMNSVMV |

700:

RTEEEIADTD | LKQEEPPSDL | ASAYVTEDLE | SPTIVHQVHQ | TIDDETILIV |

750:

PSPHGFIQAS | DVIDTESVLP | LTTLTDPIFQ | HHQEASNIIG | SSLGSPVSED |

761:

SKDVEDLVNC | H

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

String:

Pfam:

UniGene:

KEGG:

STRING:

10090.ENSMUSP00000071815

Uniprot:

FOR

ELISA Kit for Mouse Cyclin-D-binding Myb-like transcription factor 1

ELISA Kit for Mouse Cyclin-D-binding Myb-like transcription factor 1

ELISA Kit for Mouse Cyclin-D-binding Myb-like transcription factor 1

CLIA Kit for Mouse Cyclin-D-binding Myb-like transcription factor 1

CLIA Kit for Mouse Cyclin-D-binding Myb-like transcription factor 1

CLIA Kit for Mouse Cyclin-D-binding Myb-like transcription factor 1

Polyclonal Antibody for Mouse Cyclin-D-binding Myb-like transcription factor 1

Polyclonal Antibody for Mouse Cyclin-D-binding Myb-like transcription factor 1

Polyclonal Antibody for Mouse Cyclin-D-binding Myb-like transcription factor 1

Monoclonal Antibody for Mouse Cyclin-D-binding Myb-like transcription factor 1

Monoclonal Antibody for Mouse Cyclin-D-binding Myb-like transcription factor 1

Monoclonal Antibody for Mouse Cyclin-D-binding Myb-like transcription factor 1

Protein for Mouse Cyclin-D-binding Myb-like transcription factor 1

Protein for Mouse Cyclin-D-binding Myb-like transcription factor 1

Protein for Mouse Cyclin-D-binding Myb-like transcription factor 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1."
Hirai H. , Sherr C.J.
Mol. Cell. Biol.16:6457-6467(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;DNA-BINDING;INTERACTION WITH CCND1; CCND2 AND CCND3;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;PHOSPHORYLATION
strain: C57BL/Kaplan.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-276 (ISOFORM 4)
strain: C57BL/6J.
tissue: Corpora quadrigemina.
tissue: Embryo.
tissue: Medulla oblongata.
tissue: Skin.
tissue: Spinal cord.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Olfactory epithelium.
4.

"Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins."
Inoue K. , Sherr C.J. , Shapiro L.H.
J. Biol. Chem.273:29188-29194(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;MUTAGENESIS OF LYS-319
5.

"Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism."
Inoue K. , Sherr C.J.
Mol. Cell. Biol.18:1590-1600(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH CCND1 AND CCND2;SUBCELLULAR LOCATION;PHOSPHORYLATION;MUTAGENESIS OF LYS-319
6.

"Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1."
Inoue K. , Roussel M.F. , Sherr C.J.
Proc. Natl. Acad. Sci. U.S.A.96:3993-3998(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;SUBCELLULAR LOCATION
7.

"Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis."
Inoue K. , Wen R. , Rehg J.E. , Adachi M. , Cleveland J.L. , Roussel M.F. , Sherr C.J.
Genes Dev.14:1797-1809(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
8.

"Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas."
Inoue K. , Zindy F. , Randle D.H. , Rehg J.E. , Sherr C.J.
Genes Dev.15:2934-2939(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
9.

"Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor."
Sreeramaneni R. , Chaudhry A. , McMahon M. , Sherr C.J. , Inoue K.
Mol. Cell. Biol.25:220-232(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
10.

"Expression of Dmp1 in specific differentiated, nonproliferating cells and its regulation by E2Fs."
Mallakin A. , Taneja P. , Matise L.A. , Willingham M.C. , Inoue K.
Oncogene25:7703-7713(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
11.

"Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer."
Mallakin A. , Sugiyama T. , Taneja P. , Matise L.A. , Frazier D.P. , Choudhary M. , Hawkins G.A. , D'Agostino R.B. Jr. , Willingham M.C. , Inoue K.
Cancer Cell12:381-394(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION
12.

"Repression of Dmp1 and Arf transcription by anthracyclins: critical roles of the NF-kappaB subunit p65."
Taneja P. , Mallakin A. , Matise L.A. , Frazier D.P. , Choudhary M. , Inoue K.
Oncogene26:7457-7466(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION

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