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Index > Protein center > DSG2(Gene name) > Human
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  • DSG2 (Gene name),
  • Desmoglein-2 (Protein name ),  DSG2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    DSG2(CDHF5);
    Protein name:
    Desmoglein-2;
    Alternative:
    HDGC;Cadherin family member 5;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Cell junction desmosome
    Protein Attributes:
    Sequence length:
    1118
    Sequence:
    50:
    MARSPGRAYA | LLLLLICFNV | GSGLHLQVLS | TRNENKLLPK | HPHLVRQKRA | 
    100:
    WITAPVALRE | GEDLSKKNPI | AKIHSDLAEE | RGLKITYKYT | GKGITEPPFG | 
    150:
    IFVFNKDTGE | LNVTSILDRE | ETPFFLLTGY | ALDARGNNVE | KPLELRIKVL | 
    200:
    DINDNEPVFT | QDVFVGSVEE | LSAAHTLVMK | INATDADEPN | TLNSKISYRI | 
    250:
    VSLEPAYPPV | FYLNKDTGEI | YTTSVTLDRE | EHSSYTLTVE | ARDGNGEVTD | 
    300:
    KPVKQAQVQI | RILDVNDNIP | VVENKVLEGM | VEENQVNVEV | TRIKVFDADE | 
    350:
    IGSDNWLANF | TFASGNEGGY | FHIETDAQTN | EGIVTLIKEV | DYEEMKNLDF | 
    400:
    SVIVANKAAF | HKSIRSKYKP | TPIPIKVKVK | NVKEGIHFKS | SVISIYVSES | 
    450:
    MDRSSKGQII | GNFQAFDEDT | GLPAHARYVK | LEDRDNWISV | DSVTSEIKLA | 
    500:
    KLPDFESRYV | QNGTYTVKIV | AISEDYPRKT | ITGTVLINVE | DINDNCPTLI | 
    550:
    EPVQTICHDA | EYVNVTAEDL | DGHPNSGPFS | FSVIDKPPGM | AEKWKIARQE | 
    600:
    STSVLLQQSE | KKLGRSEIQF | LISDNQGFSC | PEKQVLTLTV | CECLHGSGCR | 
    650:
    EAQHDSYVGL | GPAAIALMIL | AFLLLLLVPL | LLLMCHCGKG | AKGFTPIPGT | 
    700:
    IEMLHPWNNE | GAPPEDKVVP | SFLPVDQGGS | LVGRNGVGGM | AKEATMKGSS | 
    750:
    SASIVKGQHE | MSEMDGRWEE | HRSLLSGRAT | QFTGATGAIM | TTETTKTARA | 
    800:
    TGASRDMAGA | QAAAVALNEE | FLRNYFTDKA | ASYTEEDENH | TAKDCLLVYS | 
    850:
    QEETESLNAS | IGCCSFIEGE | LDDRFLDDLG | LKFKTLAEVC | LGQKIDINKE | 
    900:
    IEQRQKPATE | TSMNTASHSL | CEQTMVNSEN | TYSSGSSFPV | PKSLQEANAE | 
    950:
    KVTQEIVTER | SVSSRQAQKV | ATPLPDPMAS | RNVIATETSY | VTGSTMPPTT | 
    1000:
    VILGPSQPQS | LIVTERVYAP | ASTLVDQPYA | NEGTVVVTER | VIQPHGGGSN | 
    1050:
    PLEGTQHLQD | VPYVMVRERE | SFLAPSSGVQ | PTLAMPNIAV | GQNVTVTERV | 
    1100:
    LAPASTLQSS | YQIPTENSMT | ARNTTVSGAG | VPGPLPDFGL | EESGHSNSTI | 
    1118:
    TTSSTRVTKH | STVQHSYS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    Pfam:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Desmoglein-2
    Cat.:
    E1462h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Desmoglein-2
    Cat.:
    E1462m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Desmoglein-2
    Cat.:
    U1462m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Desmoglein-2
    Cat.:
    U1462h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Desmoglein-2
    Cat.:
    P1462Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Desmoglein-2
    Cat.:
    P1462Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Desmoglein-2
    Monoclonal Antibody for Human Desmoglein-2
    Protein for Human Desmoglein-2
    Protein for Human Desmoglein-2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins."
      Schaefer S. , Koch P.J. , Franke W.W.
      Exp. Cell Res.211:391-399(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Colon carcinoma.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "Complete amino acid sequence of the epidermal desmoglein precursor polypeptide and identification of a second type of desmoglein gene."
      Koch P.J. , Goldschmidt M.D. , Walsh M.J. , Zimbelmann R. , Franke W.W.
      Eur. J. Cell Biol.55:200-208(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 778-1118
    4. 4.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-112
    5. 5.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182
      tissue: Plasma.
    6. 6.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112 AND ASN-182
      tissue: Liver.
    10. 10.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-462
    11. 11.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182 AND ASN-462
      tissue: Leukemic T-cell.
    12. 12.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    13. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680 AND SER-1118;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680 AND SER-703;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Solution structure of the first cadherin domain from human desmoglein-2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2007-10) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 47-162
    17. 17.
      "DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy."
      Awad M.M. , Dalal D. , Cho E. , Amat-Alarcon N. , James C. , Tichnell C. , Tucker A. , Russell S.D. , Bluemke D.A. , Dietz H.C. , Calkins H. , Judge D.P.
      Am. J. Hum. Genet.79:136-142(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARVD10 GLN-46; HIS-49; TYR-507 AND CYS-812
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-56; GLY-158; VAL-293; LYS-713; LYS-773 AND GLY-920;INVOLVEMENT IN SUSCEPTIBILITY TO CMD1BB
    19. 19.
      "Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."
      den Haan A.D. , Tan B.Y. , Zikusoka M.N. , Llado L.I. , Jain R. , Daly A. , Tichnell C. , James C. , Amat-Alarcon N. , Abraham T. , Russell S.D. , Bluemke D.A. , Calkins H. , Dalal D. , Judge D.P.
      Circ. Cardiovasc. Genet.2:428-435(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARVD10 GLN-46; HIS-49; ALA-335; TYR-507 AND CYS-812;VARIANT MET-56
    20. 20.
      "Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."
      Barahona-Dussault C. , Benito B. , Campuzano O. , Iglesias A. , Leung T.L. , Robb L. , Talajic M. , Brugada R.
      Clin. Genet.77:37-48(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARVD10 HIS-49;VARIANTS VAL-293; LYS-713; LYS-773 AND GLY-920
    21. 21.
      "Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."
      Gehmlich K. , Syrris P. , Peskett E. , Evans A. , Ehler E. , Asimaki A. , Anastasakis A. , Tsatsopoulou A. , Vouliotis A.I. , Stefanadis C. , Saffitz J.E. , Protonotarios N. , McKenna W.J.
      Cardiovasc. Res.90:77-87(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARVD10 HIS-49
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