Adar ELISA Kit for Mouse(Mus musculus) | EIAab.comAdar ELISA Kit for Mouse(Mus musculus)

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Adar (Gene name),

Double-stranded RNA-specific adenosine deaminase (Protein name ), DSRAD_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Adar;

Protein name:

Double-stranded RNA-specific adenosine deaminase(DRADA);

Alternative:

RNA adenosine deaminase 1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90.

Function:

Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses (By similarity). Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.

Subcellular Location:

Isoform 4 Nucleus nucleolus Short forms starting at Met-519 are found exclusively in the nucleolus.

Protein Attributes:

Sequence length:

1178

Sequence:

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1150:

1178:

SLRDMGYGNW | ISKPQEEKNF | YLCPVPND

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q99MU3

Pfam:

PF02137

UniGene:

Mm.316628

KEGG:

mmu:56417

String:

Q99MU3

Uniprot:

Q99MU3

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ELISA Kit for Mouse DRADA

Cat.:

E10803h

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MSDS:

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Packing:

96T

ELISA Kit for Mouse DRADA

Cat.:

E10803m

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Mouse DRADA

Cat.:

E10803r

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Mouse DRADA

Cat.:

U10803r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse DRADA

Cat.:

U10803h

Price:

Please sign in first.

MSDS:

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Packing:

96T

CLIA Kit for Mouse DRADA

Cat.:

U10803m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse DRADA

Cat.:

P10803Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse DRADA

Monoclonal Antibody for Mouse DRADA

Protein for Mouse DRADA

Cat.:

R10803h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Mouse DRADA

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Intracellular localization of differentially regulated RNA-specific adenosine deaminase isoforms in inflammation."
Yang J.-H. , Nie Y. , Zhao Q. , Su Y. , Pypaert M. , Su H. , Rabinovici R.
J. Biol. Chem.278:45833-45842(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION
strain: C57BL/6J.
tissue: Spleen.
2.

"Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation."
Yang J.-H. , Luo X. , Nie Y. , Su Y. , Zhao Q. , Kabir K. , Zhang D.-X. , Rabinovici R.
Immunology109:15-23(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING;INDUCTION
3.

"cDNA for mouse double-stranded RNA-specific adenosine deaminase (ADAR1)."
Young S.B. , Carmichael G.G.
Submitted (1998-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Fibroblast.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS SER-20; LEU-32 AND LEU-330
strain: Czech II.
tissue: Mammary tumor.
5.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1173 (ISOFORM 1)
strain: C57BL/6J.
tissue: Dendritic cell.
6.

"Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA."
Cho D.-S.C. , Yang W. , Lee J.T. , Shiekhattar R. , Murray J.M. , Nishikura K.
J. Biol. Chem.278:17093-17102(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMODIMERIZATION
7.

"Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1."
Hartner J.C. , Schmittwolf C. , Kispert A. , Mueller A.M. , Higuchi M. , Seeburg P.H.
J. Biol. Chem.279:4894-4902(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
8.

"Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene."
Wang Q. , Miyakoda M. , Yang W. , Khillan J. , Stachura D.L. , Weiss M.J. , Nishikura K.
J. Biol. Chem.279:4952-4961(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
9.

"ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells."
Yang W. , Wang Q. , Howell K.L. , Lee J.T. , Cho D.-S.C. , Murray J.M. , Nishikura K.
J. Biol. Chem.280:3946-3953(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing."
Nie Y. , Ding L. , Kao P.N. , Braun R. , Yang J.-H.
Mol. Cell. Biol.25:6956-6963(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ILF2 AND ILF3
11.

"Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection."
Nie Y. , Hammond G.L. , Yang J.H.
J. Virol.81:917-923(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EIF2AK2
12.

"Editing modifies the GABA(A) receptor subunit alpha3."
Ohlson J. , Pedersen J.S. , Haussler D. , Ohman M.
RNA13:698-703(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Adenosine deaminases acting on RNA, RNA editing, and interferon action."
George C.X. , Gan Z. , Liu Y. , Samuel C.E.
J. Interferon Cytokine Res.31:99-117(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW

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