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Index > Protein center > Dtx3l(Gene name) > Mouse
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  • Dtx3l (Gene name),
  • E3 ubiquitin-protein ligase DTX3L (Protein name ),  DTX3L_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Dtx3l(Bbap);
    Protein name:
    E3 ubiquitin-protein ligase DTX3L;
    Alternative:
    Protein deltex-3-like;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer and heterodimer. Can heterodimerize with DTX1, enhancing its ubiquitin ligase activity in vitro. Interacts with PARP9/BAL1. Found in a complex with MYO6.
    Function:
    Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    748
    Sequence:
    50:
    MASSPDPPSP | LLVRLRESIP | KAHRKLEIYF | QSRASGGGEC | SVQPVGPSAP | 
    100:
    DTYEVKFLKK | ADKEKVLKKS | EHEMLVHNKP | VTIVLETTKK | PVEDLRPRLP | 
    150:
    SLTQPVETPS | SRPPSLTGSL | DEALCDDIHP | QDGLVSNSVD | SVVQKIFLAV | 
    200:
    TAELNCDLLS | KEQRASITTV | CPHIIKSMEG | SDGIKKVCGN | FKDIEKIHHF | 
    250:
    LSEQLLEREQ | KRKGSEQKRK | CAPQKHTPPD | VEREPPDQSS | IQVPVLLLEY | 
    300:
    FKHVNPGRLE | FIEYKFGVNI | EIQASSPNMV | TVGFTSSPFG | NVEEASQSFV | 
    350:
    RDFQKCSQSL | KQDCISLEEH | QRAKEVRQEL | SRCFPKLLIK | GQGRTLTLLG | 
    400:
    SPADISAATE | KVSQGLGLRP | VKITASGYTT | GIEVDSTRFK | LLEPELLQEI | 
    450:
    SEIEQKFNTR | GKVQEKGQKT | CILFVPKDKD | LDLSVQSYTG | FTDAFQRATW | 
    500:
    QLRTEVLSLK | GLGKERARLH | NTKFADNFKK | EHPNVHFVTS | QESVTLTGLP | 
    550:
    HHLAQAMQYV | SKRMGLAPSS | GEKLAMDQET | PMEISSSDPH | GDQQENAALP | 
    600:
    APRGTSSSPA | ASKGTEDYCV | ICMDTISNKH | VLPKCKHEFC | TSCISKAMLI | 
    650:
    KPVCPVCLTS | YGIQKGNQPE | GTMSYSTQKG | SLPGYEGCGT | IVINYEIKDG | 
    700:
    IQTKEHPNPG | KAYHGTRRTA | YLPDNTEGRK | VLDLLHEAFK | HRLTFTIGYS | 
    748:
    RATGVSDVIT | WNDIHHKTSK | FGGPANFGYP | DPDYLKRVKE | ELKAKGIE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase DTX3L
    ELISA Kit for Mouse E3 ubiquitin-protein ligase DTX3L
    CLIA Kit for Mouse E3 ubiquitin-protein ligase DTX3L
    CLIA Kit for Mouse E3 ubiquitin-protein ligase DTX3L
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase DTX3L
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase DTX3L
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase DTX3L
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase DTX3L
    Protein for Mouse E3 ubiquitin-protein ligase DTX3L
    Protein for Mouse E3 ubiquitin-protein ligase DTX3L

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Amnion.
      tissue: Lymph node.
    2. 2.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    4. 4.
      "The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues."
      Hakme A. , Huber A. , Dolle P. , Schreiber V.
      Dev. Dyn.237:209-215(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
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