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Index > Protein center > DUSP4(Gene name) > Human
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  • DUSP4 (Gene name),
  • Dual specificity protein phosphatase 4 (Protein name ),  DUS4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    DUSP4(MKP2;VH2);
    Protein name:
    Dual specificity protein phosphatase 4;
    Alternative:
    Mitogen-activated protein kinase phosphatase 2(MAP kinase phosphatase 2;MKP-2);Dual specificity protein phosphatase hVH2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Hollow spherical complex composed of 24 subunits with pseudooctahedral symmetry, has a tetramer as the basic unit.
    Function:
    Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    394
    Sequence:
    50:
    MVTMEELREM | DCSVLKRLMN | RDENGGGAGG | SGSHGTLGLP | SGGKCLLLDC | 
    100:
    RPFLAHSAGY | ILGSVNVRCN | TIVRRRAKGS | VSLEQILPAE | EEVRARLRSG | 
    150:
    LYSAVIVYDE | RSPRAESLRE | DSTVSLVVQA | LRRNAERTDI | CLLKGGYERF | 
    200:
    SSEYPEFCSK | TKALAAIPPP | VPPSATEPLD | LGCSSCGTPL | HDQGGPVEIL | 
    250:
    PFLYLGSAYH | AARRDMLDAL | GITALLNVSS | DCPNHFEGHY | QYKCIPVEDN | 
    300:
    HKADISSWFM | EAIEYIDAVK | DCRGRVLVHC | QAGISRSATI | CLAYLMMKKR | 
    350:
    VRLEEAFEFV | KQRRSIISPN | FSFMGQLLQF | ESQVLATSCA | AEAASPSGPL | 
    394:
    RERGKTPATP | TSQFVFSFPV | SVGVHSAPSS | LPYLHSPITT | SPSC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Dual specificity protein phosphatase 4
    Cat.:
    E12250h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Dual specificity protein phosphatase 4
    MSDS:
    Please sign in first.
    ELISA Kit for Human Dual specificity protein phosphatase 4
    Cat.:
    E12250m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Dual specificity protein phosphatase 4
    Cat.:
    E12250r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Dual specificity protein phosphatase 4
    MSDS:
    Please sign in first.
    CLIA Kit for Human Dual specificity protein phosphatase 4
    Cat.:
    U12250r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dual specificity protein phosphatase 4
    Cat.:
    U12250m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dual specificity protein phosphatase 4
    Cat.:
    U12250h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Dual specificity protein phosphatase 4
    Polyclonal Antibody for Human Dual specificity protein phosphatase 4
    Polyclonal Antibody for Human Dual specificity protein phosphatase 4
    Polyclonal Antibody for Human Dual specificity protein phosphatase 4
    Cat.:
    P12250Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Dual specificity protein phosphatase 4
    Monoclonal Antibody for Human Dual specificity protein phosphatase 4
    Monoclonal Antibody for Human Dual specificity protein phosphatase 4
    Monoclonal Antibody for Human Dual specificity protein phosphatase 4
    Protein for Human Dual specificity protein phosphatase 4
    Protein for Human Dual specificity protein phosphatase 4
    Protein for Human Dual specificity protein phosphatase 4
    Protein for Human Dual specificity protein phosphatase 4

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    Precision
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase."
      Guan K.-L. , Butch E.
      J. Biol. Chem.270:7197-7203(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation."
      Chu Y. , Solski P.A. , Khosravi-Far R. , Der C.J. , Kelly K.
      J. Biol. Chem.271:6497-6501(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skin.
      tissue: Uterus.
    7. 8.
      "Post-translational regulation of mitogen-activated protein kinase phosphatase-2 (MKP-2) by ERK."
      Peng D.J. , Zhou J.Y. , Wu G.S.
      Cell Cycle9:4650-4655(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-386 AND SER-391
    8. 9.
      "Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2."
      Cadalbert L.C. , Sloss C.M. , Cunningham M.R. , Al-Mutairi M. , McIntire A. , Shipley J. , Plevin R.
      Cell. Signal.22:357-365(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 11.
      "Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly."
      Jeong D.G. , Jung S.K. , Yoon T.S. , Woo E.J. , Kim J.H. , Park B.C. , Ryu S.E. , Kim S.J.
      Proteins76:763-767(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 194-336;SUBUNIT
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