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Index > Protein center > Dvl2(Gene name) > Mouse
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  • Dvl2 (Gene name),
  • Segment polarity protein dishevelled homolog DVL-2 (Protein name ),  DVL2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Dvl2;
    Protein name:
    Segment polarity protein dishevelled homolog DVL-2(Dishevelled-2);
    Alternative:
    DSH homolog 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex.
    Function:
    Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytosol Cytoplasmic vesicle Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta.
    Protein Attributes:
    Sequence length:
    736
    Sequence:
    50:
    MAGSSAGGGG | VGETKVIYHL | DEEETPYLVK | IPVPAERITL | GDFKSVLQRP | 
    100:
    AGAKYFFKSM | DQDFGVVKEE | ISDDNARLPC | FNGRVVSWLV | SSDTPQPEVA | 
    150:
    PPAHESRTEL | VPPPPPLPPL | PPERTSGIGD | SRPPSFHPNV | SSSHENLEPE | 
    200:
    TETESVVSLR | RDRPRRRDSS | EHGAGGHRPG | GPSRLERHLA | GYESSSTLMT | 
    250:
    SELESTSLGD | SDEDDTMSRF | SSSTEQSSAS | RLLKRHRRRR | KQRPPRMERT | 
    300:
    SSFSSVTDST | MSLNIITVTL | NMEKYNFLGI | SIVGQSNERG | DGGIYIGSIM | 
    350:
    KGGAVAADGR | IEPGDMLLQV | NDMNFENMSN | DDAVRVLRDI | VHKPGPIVLT | 
    400:
    VAKCWDPSPQ | AYFTLPRNEP | IQPIDPAAWV | SHSAALTGAF | PAYPGSSSMS | 
    450:
    TITSGSSLPD | GCEGRGLSVH | MDMASVTKAM | AAPESGLEVR | DRMWLKITIP | 
    500:
    NAFLGSDVVD | WLYHHVEGFP | ERREARKYAS | GLLKAGLIRH | TVNKITFSEQ | 
    550:
    CYYVFGDLSG | GCESYLVNLS | LNDNDGSSGA | SDQDTLAPLP | GATPWPLLPT | 
    600:
    FSYQYPAPHP | YSPQPPPYHE | LSSYTYGGGS | ASSQHSEGSR | SSGSTRSDGG | 
    650:
    AGRTGRPEER | APESKSGSGS | ESELSSRGGS | LRRGGEPGGT | GDGGPPPSRG | 
    700:
    STGAPPNLRA | LPGLHPYGAP | SGMALPYNPM | MVVMMPPPPP | PVSTAVQPPG | 
    736:
    APPVRDLGSV | PPELTASRQS | FHMAMGNPSE | FFVDVM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Dishevelled-2
    ELISA Kit for Mouse Dishevelled-2
    CLIA Kit for Mouse Dishevelled-2
    CLIA Kit for Mouse Dishevelled-2
    Polyclonal Antibody for Mouse Dishevelled-2
    Polyclonal Antibody for Mouse Dishevelled-2
    Monoclonal Antibody for Mouse Dishevelled-2
    Monoclonal Antibody for Mouse Dishevelled-2
    Protein for Mouse Dishevelled-2
    Protein for Mouse Dishevelled-2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2."
      Klingensmith J. , Yang Y. , Axelrod J.D. , Beier D.R. , Perrimon N. , Sussman D.J.
      Mech. Dev.58:15-26(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Amnion.
      tissue: Kidney.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
    6. 6.
      "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
      Wong C.K. , Luo W. , Deng Y. , Zou H. , Ye Z. , Lin S.-C.
      J. Biol. Chem.279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DIXDC1 AND RAC
    7. 7.
      "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family."
      Torban E. , Wang H.-J. , Groulx N. , Gros P.
      J. Biol. Chem.279:52703-52713(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VANGL1 AND VANGL2
    8. 8.
      "Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling."
      Yu A. , Rual J.F. , Tamai K. , Harada Y. , Vidal M. , He X. , Kirchhausen T.
      Dev. Cell12:129-141(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH THE AP-2 COMPLEX
    9. 9.
      "Molecular basis of Wnt activation via the DIX-domain protein Ccd1."
      Liu Y.T. , Dan Q.J. , Wang J. , Feng Y. , Chen L. , Liang J. , Li Q. , Lin S.C. , Wang Z.X. , Wu J.W.
      J. Biol. Chem.286:8597-8608(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DIXDC1;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-15; ILE-17; TYR-27; PHE-56; ASP-61; ASP-63; GLY-65; VAL-66 AND LYS-68;DOMAIN
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAM105B
    11. 11.
      "Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling."
      Yu A. , Xing Y. , Harrison S.C. , Kirchhausen T.
      Structure18:1311-1320(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 417-510 IN COMPLEX WITH AP2M1;FUNCTION;SUBUNIT;SUBCELLULAR LOCATION
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