Protein name:
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) ;
Alternative:
DSH homolog 2 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex.
Function:
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasm
cytosol
Cytoplasmic vesicle
Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta.
Protein Attributes:
50:
MAGSSAGGGG | VGETKVIYHL | DEEETPYLVK | IPVPAERITL | GDFKSVLQRP |
100:
AGAKYFFKSM | DQDFGVVKEE | ISDDNARLPC | FNGRVVSWLV | SSDTPQPEVA |
150:
PPAHESRTEL | VPPPPPLPPL | PPERTSGIGD | SRPPSFHPNV | SSSHENLEPE |
200:
TETESVVSLR | RDRPRRRDSS | EHGAGGHRPG | GPSRLERHLA | GYESSSTLMT |
250:
SELESTSLGD | SDEDDTMSRF | SSSTEQSSAS | RLLKRHRRRR | KQRPPRMERT |
300:
SSFSSVTDST | MSLNIITVTL | NMEKYNFLGI | SIVGQSNERG | DGGIYIGSIM |
350:
KGGAVAADGR | IEPGDMLLQV | NDMNFENMSN | DDAVRVLRDI | VHKPGPIVLT |
400:
VAKCWDPSPQ | AYFTLPRNEP | IQPIDPAAWV | SHSAALTGAF | PAYPGSSSMS |
450:
TITSGSSLPD | GCEGRGLSVH | MDMASVTKAM | AAPESGLEVR | DRMWLKITIP |
500:
NAFLGSDVVD | WLYHHVEGFP | ERREARKYAS | GLLKAGLIRH | TVNKITFSEQ |
550:
CYYVFGDLSG | GCESYLVNLS | LNDNDGSSGA | SDQDTLAPLP | GATPWPLLPT |
600:
FSYQYPAPHP | YSPQPPPYHE | LSSYTYGGGS | ASSQHSEGSR | SSGSTRSDGG |
650:
AGRTGRPEER | APESKSGSGS | ESELSSRGGS | LRRGGEPGGT | GDGGPPPSRG |
700:
STGAPPNLRA | LPGLHPYGAP | SGMALPYNPM | MVVMMPPPPP | PVSTAVQPPG |
736:
APPVRDLGSV | PPELTASRQS | FHMAMGNPSE | FFVDVM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Dishevelled-2
ELISA Kit for Mouse Dishevelled-2
CLIA Kit for Mouse Dishevelled-2
CLIA Kit for Mouse Dishevelled-2
Polyclonal Antibody for Mouse Dishevelled-2
Polyclonal Antibody for Mouse Dishevelled-2
Monoclonal Antibody for Mouse Dishevelled-2
Monoclonal Antibody for Mouse Dishevelled-2
Protein for Mouse Dishevelled-2
Protein for Mouse Dishevelled-2
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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BALB/c .
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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C57BL/6 .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DIXDC1 AND RAC
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH VANGL1 AND VANGL2
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH THE AP-2 COMPLEX
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH DIXDC1;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-15; ILE-17; TYR-27; PHE-56; ASP-61; ASP-63; GLY-65; VAL-66 AND LYS-68;DOMAIN
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Nature498:318-324(2013)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FAM105B
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 417-510 IN COMPLEX WITH AP2M1;FUNCTION;SUBUNIT;SUBCELLULAR LOCATION