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Index > Protein center > Dync2h1(Gene name) > Rat
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  • Dync2h1 (Gene name),
  • Cytoplasmic dynein 2 heavy chain 1 (Protein name ),  DYHC2_RAT from NCBI database.
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  • Antigen Annotation
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  • Gene name:
    Dync2h1(Dhc1b;Dlp4;Dnch2;Dnchc2);
    Protein name:
    Cytoplasmic dynein 2 heavy chain 1;
    Alternative:
    Dynein cytoplasmic heavy chain 2;Cytoplasmic dynein 2 heavy chain;Dynein-like protein 4;Dynein heavy chain isotype 1B;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    The cytoplasmic dynein complex 2 is probably composed by an heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains.
    Function:
    May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells.
    Subcellular Location:
    Cytoplasm cytoskeleton cilium axoneme Cell membrane Peripheral membrane protein Cytoplasm Localizes to the apical cytoplasm. May localize to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum.
    Protein Attributes:
    Sequence length:
    4306
    Sequence:
    50:
    MAGSLSDVRK | LFLFTTTQNY | FGLRPELWDQ | TPLSNCPEVN | NFLDDGNQML | 
    100:
    LRVQRSDAGL | AFSNTIDFDD | TKDKVLVFFK | LRPEVITDGN | LHTNILVSSM | 
    150:
    LESPINSLYQ | AVRQVFAPML | LKDQEWSRNF | DPKLQNLLSE | LEAGLGVVLR | 
    200:
    KSDTNLPKLK | LKEDDTRGIL | TPSDEFQFWI | EQAHRGSKQI | SKERASYFKE | 
    250:
    LFETIAREFY | NLDSLSLLEV | VDLVETTRDV | VDDVWRQAEH | DHYPESRMLH | 
    300:
    LLDVIGGSFG | RFVQKKLGSL | KLWEDPYYLV | KENLKAGISI | CEQWVIVCSH | 
    350:
    LTGQVWQRYV | PHPWKSEKYF | PETLDRLGKR | LEEVLAIRTI | HEKLLYFLPA | 
    400:
    SEERIVCLSR | VFEPFTGVNP | VQYNPYTEPL | WKAAVSQYEK | IIAPAEQKIA | 
    450:
    GKLKNYISEI | QDSPQQLLQA | FLKYKELVKR | PTISKELMLE | RETLLARLGD | 
    500:
    SAKDFRLDFE | NRCRGIPGDA | SGPLSGKNLS | EVVNNIVWVR | QLELKVDDTI | 
    550:
    KIAEALLSDL | SGFRSFHRSA | EDLLDQFKLY | EQEQFDDWSR | EVQSGLSDSR | 
    600:
    SGLCIEANSR | IMELDPNDGA | LKVHYSDRLV | ILLREVRQLS | ALGFVIPAKI | 
    650:
    QQVANVAQKF | CKQAIILKQV | AHFYNSIDQQ | MIQSQRPMML | QSALAFEQII | 
    700:
    KNSKAGSGGK | SQITWDNPKE | LEGYIQKLQN | AAERLATENR | RLRKWHITFC | 
    750:
    EKVVILMNID | LLRQQQRWKD | GLQELRTGLA | SVAAQGFQPS | DMRAWRQHWN | 
    800:
    HQLYKALEHQ | YQMGLEALNE | NLPEINVDLT | YKQGRLQFRP | PFEEIRAKYY | 
    850:
    REMKRFIGIP | NQFKGVGGAG | DESIFSVMID | RNASGFLTIY | SKAEDLFRRL | 
    900:
    SAVLHQHKEW | VVIGQVDMEA | LVEKNLSTVH | DWEKNFKALK | IKGKEVERLP | 
    950:
    SAVKVDCLNI | NCSPVKTVID | DLIQKLFDLL | VLSLKKSIQT | HIHEIDTFVT | 
    1000:
    EAMKVLTVIP | QSVEEIGDTN | LQYSNLQDRR | PEILPLFQEA | EDKNRLLRTV | 
    1050:
    AGGGVETVSN | LRAKWDKFEL | MMESHQLMIK | DQIEVMKGNV | KSRLQIYYQE | 
    1100:
    LDKFKARWDQ | LKPGDDIIET | GQQNTMDQSA | KSIKEKKIEF | DDLEVIRKKL | 
    1150:
    VDDCHHFGLE | ESNFSLAYSI | SKDIESCAQI | WALYEEFQQG | LQEMAKEDWI | 
    1200:
    TYRTKIYIFE | EFLINWHERL | RKVEEHSVMT | VKLQSEVDRY | KIIIPILKYV | 
    1250:
    RGEHLSPDHW | LDLFRLLGLP | RGTSLEKLLF | GDLLRVADTI | VEKASDLKDL | 
    1300:
    NSRAQGEVTI | REALRELDLW | GVGAVFSLID | YEDSQNRTIK | LIKDWKDIVN | 
    1350:
    QVGDNRCLLQ | SLKDSPYYKG | FEDKVSIWER | KLAQLDEYLQ | NLNHIQRKWV | 
    1400:
    YLEPIFGRGA | LPKEQTRFNK | VDEDFRSIMM | DIRKDSRVTT | LTTHAGIRNT | 
    1450:
    LLTILDQLQR | CQKSLNEFLE | EKRSAFPRFY | FIGDDDLLEI | LGQSTNPSVI | 
    1500:
    QSHLKKLFAG | INSVCFDEES | KHITAMRSLE | GEVVPFKSKV | LLSNNVEAWL | 
    1550:
    NDLALEMKQT | LKQLLKECVT | AGRSSQGAID | PSLFPSQILC | LAEQIKFTED | 
    1600:
    VEDAIRDHSL | HQIEAQLAAK | LERYTSVDTS | SEDPGNSESG | ILELKLKTLI | 
    1650:
    LDIIHNIDIV | KQLNQAQVHT | TDDWAWKKQV | RFYMKSDHTC | YVQMVDSELQ | 
    1700:
    YTYEYQGNAP | KLVYTPLTDK | CYLTLTQAMK | MGLGGNPYGP | AGTGKTESVK | 
    1750:
    ALGGLLGRQV | LVFNCDEGID | VKSMGRIFVG | LVKCGAWGCF | DEFNRLEEAV | 
    1800:
    LSAVSMQIQT | IQDALKNHRS | VCELLGKEVE | VNANSGIFIT | MNPAGKGYGG | 
    1850:
    RQKLPDNLKQ | LFRPVAMSRP | DNDLIAEVIL | YSEGFKDAKE | LGRKLVAIFN | 
    1900:
    LSRELLTPQQ | HYDWGLRALK | TVLRGSGNLL | RQLKKSGTKQ | DVNENHIVVQ | 
    1950:
    ALRLNTMSKF | TFADCTRFDA | LIKDVFPGID | FKEVEYNELS | SALKQVFEEA | 
    2000:
    NYEVIPNQMK | KALELYEQLR | QRTGVVIVGP | SGAGKSTLWR | MLRAALCKIG | 
    2050:
    KVVKQYTMNP | KAMPRHQLLG | HIDMDTREWS | DGVLTNSARQ | VVREPQDVSS | 
    2100:
    WIICDGDIDP | EWIESLNSVL | DDNRLLTMPS | GERIQFGPNV | NFVFETHDLS | 
    2150:
    CASPATISRM | GMIFLSDEET | DLNSLIKSWL | RNQPVEYRSN | LENWIGDYFS | 
    2200:
    KALQWVLKQN | DYVVETSLVG | TVMNGLSHLH | GCKYHDQFII | NLIRGLGGNL | 
    2250:
    NMKSRLEFTK | EVFNWARETP | PDSHRPMDTY | FDCDRGQLAS | YVLKKPESLT | 
    2300:
    ADDFSSGHSL | PVIQTPDMQR | GLDYFKPWLS | SETKQPFILV | GPEGCGKGML | 
    2350:
    LRYAFSQLRS | TEIATIHCSA | QTTSRHLLQK | LSQTCMVIST | NTGRVYRPKD | 
    2400:
    CERLVLYLKD | INLPKLDKWG | TSTLVAFLQQ | VLTYQGFYDE | NLEWVGLENI | 
    2450:
    QIVASMSAGG | RLGRHKLTTR | FTSIVRLCAV | DYPEREQLQT | IYGAYLEAVL | 
    2500:
    HKNLKNHSIW | GSSSKIYLLA | GSMVQVYEQV | RAKFTVDDYS | HYFFTPCILT | 
    2550:
    QWVLGLFRYD | LEGGSSNHPL | DYVLEVVAYE | ARRLFRDKIV | GVKELHLFDN | 
    2600:
    ILTSVLQGDW | GSDILDNMAD | SFYVTWGAQH | ISGAKIAPGQ | PLPPHGKPLG | 
    2650:
    KLSSADLKDV | IKKGLIHYGR | DNQNLDILLF | QEVLEYMSRI | DRVLSFPGGS | 
    2700:
    LLLAGRSGVG | RRTVTSLVSH | MHGAVLFSPK | ISRGYEPKQF | RTDLKHVLHL | 
    2750:
    AGIEAQQVVL | LLEDYQFVHP | TFLEMINSLL | SSGEVPGLYT | LEELEPLLLP | 
    2800:
    LKDQASQDGF | FGPVFNYFTY | RIQQNLHIVL | IMDSANLNFI | INCESNPALH | 
    2850:
    KKCRVLWMEG | WSDSSMKKIP | EMLFSEADIE | EKYEKKRKDE | KKKSSVDPDF | 
    2900:
    IKSFLLIHES | CKAYGATPSR | YMTFLRVYSA | ISSSKRKELL | KRQSHLQAGV | 
    2950:
    SKLNEAKALV | DELNRKAGEQ | SILLRIKQDE | ADSALQEITV | SMQDASEQKT | 
    3000:
    ELERLKHRIA | EEVVKIEERK | SKIDDELKEV | QPLVNEAKLA | VGNIRPESLS | 
    3050:
    EIRSLRMPPD | VIRDILEGVL | RLMGIFDTSW | VSMKSFLAKR | GVREDIATFD | 
    3100:
    ARNIPKEIRE | SVEELLFKNK | ASFDPKNAKR | ASTAAAPLAA | WVKANVQYSH | 
    3150:
    VLERIQPLET | EQSGLELNLK | KTEDRKRKLE | DLLNSVGQKV | SELKEKFQSR | 
    3200:
    TSEAAKLEAE | VSKAQETIKA | AEVLISQLDR | EHRRWNAQVA | EIAEELATLP | 
    3250:
    KRAQLAAAFI | TYLSAAPEGL | RKNCLEEWTK | AAGLEKFDLR | RFLCTESEQL | 
    3300:
    IWKSEGLPSD | DLSIENALVI | LQSRVCPFLI | DPSSQATEWL | KTHLKDSHLE | 
    3350:
    VINQQDSNFI | TALELAVRFG | KTLIIQEMDG | VEPVLYPLLR | RDLVAQGPRY | 
    3400:
    VVQIGDKIID | YNEDFRLFLS | TRNPNPFIPP | DAASIVTEVN | FTTTRSGLRG | 
    3450:
    QLLALTIQHE | KPDLEEQKTK | LLQQEEDKKI | QLARLEESLL | ETLATSQGNI | 
    3500:
    LENKDLIESL | NQTKASSALI | QDSLKESYKL | QISLDRERDA | YLPLAESASK | 
    3550:
    MYFIISDLSK | INNMYRFSLA | SFLRLFQRAL | QNKQDSESTE | QRIQCLVNSL | 
    3600:
    KHMVYEYICR | CLFKADQLMF | ALHFVRGMHP | EFFQENEWDT | FTGVVVGDML | 
    3650:
    RKADSQQRIR | DQLPSWIDQE | RSWAVATLKI | SLPGLYQTLC | FEDGTLWRTY | 
    3700:
    YHHSMCEQEF | PSILAKKVSL | FQQVLVVQAL | RPDRLQSAMA | LFACKALGLK | 
    3750:
    ELSPLPLNLK | RLYKETLEIE | PILIIISPGA | DPSQELQELA | NAERSSERYH | 
    3800:
    QVAMGQGQAD | LAIQMLKECA | RNGDWLCLKN | LHLVVSWLPV | LEKELNTLQP | 
    3850:
    KESFRLWLTA | EVHPNFTPIL | LQSSLKITYE | SPPGLKKNLM | RTYESWTPEQ | 
    3900:
    ISKKDNIHRA | HALFSLAWFH | AACQERRNFI | PQGWTKFYEF | SLSDLRAGYH | 
    3950:
    VIDRLFDGSK | DVQWEFVHGL | LENSIYGGRI | DNYFDLRVLQ | SYLKQFFNSS | 
    4000:
    IIDVLNQRNK | KSIFPYSISL | PDSCSILDYR | AVIEKLPEDD | KPSFFGLPAN | 
    4050:
    IARSSQRMTS | SQVISQLRIL | GRSVTAGCKF | DREIWSNELS | PVLNLWKKLN | 
    4100:
    QNSNLIHQKV | SPPNDRQGSP | ILSFIILEQF | NAIRLVQSVH | QSLAALSKVI | 
    4150:
    RGTTLLSSEV | QKLASALLNQ | KCPLTWQSKW | EGPEDPLQYL | RGLVARTLAI | 
    4200:
    QNWVEKAEKQ | ALLADTLDLS | ELFHPDTFLN | ALRQETARAT | GCSVDSLKFV | 
    4250:
    ASWKGRLQEA | KLQIKISGLL | LEGCSFDGSR | LSENQHDSPS | VSSVLPCYMG | 
    4300:
    WTPQGSYGPY | SPDECISLPV | YTSAERDCVV | TNIDVPCGGN | QDQWIQCGAA | 
    4306:
    LFLKNQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Cytoplasmic dynein 2 heavy chain 1
    ELISA Kit for Rat Cytoplasmic dynein 2 heavy chain 1
    ELISA Kit for Rat Cytoplasmic dynein 2 heavy chain 1
    CLIA Kit for Rat Cytoplasmic dynein 2 heavy chain 1
    CLIA Kit for Rat Cytoplasmic dynein 2 heavy chain 1
    CLIA Kit for Rat Cytoplasmic dynein 2 heavy chain 1
    Polyclonal Antibody for Rat Cytoplasmic dynein 2 heavy chain 1
    Polyclonal Antibody for Rat Cytoplasmic dynein 2 heavy chain 1
    Polyclonal Antibody for Rat Cytoplasmic dynein 2 heavy chain 1
    Monoclonal Antibody for Rat Cytoplasmic dynein 2 heavy chain 1
    Monoclonal Antibody for Rat Cytoplasmic dynein 2 heavy chain 1
    Monoclonal Antibody for Rat Cytoplasmic dynein 2 heavy chain 1
    Protein for Rat Cytoplasmic dynein 2 heavy chain 1
    Protein for Rat Cytoplasmic dynein 2 heavy chain 1
    Protein for Rat Cytoplasmic dynein 2 heavy chain 1

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    Linearity
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    References
    1. 1.
      "Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cells."
      Mikami A. , Tynan S.H. , Hama T. , Luby-Phelps K. , Saito T. , Crandall J.E. , Besharse J.C. , Vallee R.B.
      J. Cell Sci.115:4801-4808(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH DYNC2LI1;SUBCELLULAR LOCATION
      strain: Sprague-Dawley.
      tissue: Testis.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1665-1744
      tissue: Kidney.
    3. 3.
      "Identification and molecular evolution of new dynein-like protein sequences in rat brain."
      Tanaka Y. , Zhang Z. , Hirokawa N.
      J. Cell Sci.108:1883-1893(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1670-1860;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      strain: Wistar.
      tissue: Brain.
    4. 4.
      "A novel cytoplasmic dynein heavy chain: expression of DHC1b in mammalian ciliated epithelial cells."
      Criswell P.S. , Ostrowski L.E. , Asai D.J.
      J. Cell Sci.109:1891-1898(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION
    5. 5.
      "Evidence for four cytoplasmic dynein heavy chain isoforms in rat testis."
      Criswell P.S. , Asai D.J.
      Mol. Biol. Cell9:237-247(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      "Identification of a novel light intermediate chain (D2LIC) for mammalian cytoplasmic dynein 2."
      Grissom P.M. , Vaisberg E.A. , McIntosh J.R.
      Mol. Biol. Cell13:817-829(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DYNC2LI1
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